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40
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Hyperlink
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URL
https://doi.org/10.1016/j.chest.2022.11.042
Dublin Core
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Title
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Diagnostic Test Accuracy of Lung Ultrasound for Acute Chest Syndrome in Sickle Cell Disease: A Systematic Review and Meta-analysis
Creator
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Mahmoud Omar
Abdur Rahman Jabir
Imadh Khan
Enrico M Novelli
Julia Z Xu
Date
A point or period of time associated with an event in the lifecycle of the resource
2022
Description
An account of the resource
Background: Acute chest syndrome (ACS) is a leading cause of death in patients with sickle cell disease (SCD). Lung ultrasound (LUS) is emerging as a point-of-care method to diagnose ACS, allowing for more rapid diagnosis in the emergency room setting and sparing patients from ionizing radiation exposure.
Research question: What is the diagnostic accuracy of LUS for ACS diagnosis using the current reference standard of chest x-ray?
Study design and methods: Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed for this systematic review and meta-analysis. Embase, MEDLINE, Web of Science, and Google Scholar were used to compile all relevant studies. Two reviewers screened the studies for inclusion in this review. Cases of discrepancy were resolved by a third reviewer. Meta-analyses were conducted using both metadta and midas STATA software packages to retrieve summary receiver operating characteristic curves, sensitivities, and specificities. Three reviewers scored the studies with QUADAS-2 for risk of bias assessment.
Results: From a total of 713 unique studies retrieved, 6 studies were included in the final quantitative synthesis. Of these, 5 studies were in pediatric emergency departments. Two studies were conference abstracts and not published manuscripts. Data was available for 625 possible ACS cases (97% of cases in patients aged ≤ 21 years) and 95 confirmed ACS diagnoses (pre-test probability of 15.2%). The summary sensitivity was 0.92 (95% CI, 0.68-0.98) and the summary specificity was 0.89 (95% CI, 0.69-0.97) with an area under the curve of the summary receiver operating characteristic curve of 0.96 (95% CI, 0.94-0.97).
Interpretation: LUS has excellent sensitivity and very good specificity for ACS diagnosis and may serve as an initial point-of-care test to facilitate rapid treatment of ACS and spare pediatric patients from ionizing radiation; however, further research is warranted to improve the generalizability to the adult SCD population.
Source
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Chest
. 2022 Dec 9;S0012-3692(22)04217-9. doi: 10.1016/j.chest.2022.11.042. Online ahead of print.
Language
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English
2022
acute chest syndrome
Diagnosis
point-of-care testing
sickle cell anemia
sickle cell disease
Ultrasound
X-Ray
-
Text
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URL Address
<a href="http://doi.org/10.1002/ajpa.1330960404" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ajpa.1330960404</a>
Rights
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Pages
4055-4060
Issue
6
Volume
21
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Title
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Comparison of radiological and gross examination for detection of cancer in de-fleshed skeletons
Publisher
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Anticancer Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-11
Subject
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cancer; defleshed bones; erosive arthritis; lesions; metastasis; metastasizing carcinoma; Oncology; skeletal pathology; X-ray
Creator
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Rothschild B M; Rothschild C
Description
An account of the resource
The reliability of visual examination of de-fleshed bones was assessed for detection of postcranial metastatic disease in individuals known to have had cancer. This was compared with standard clinical radiological techniques. The skeletons of 128 diagnosed cancer patients from an early 20th century autopsied skeletal collection (Hamann-Todd Collection) were examined. Radiological examination detected evidence of metastatic disease in 33 individuals, compared to 11 by visual examination of the postcranial skeletons. Four of these cases were detected by both techniques. Blastic lesions were most commonly overlooked on visual examination, because they were localized to trabecular (internal bone) structures. The ilium was the most commonly affected bone, with lytic or blastic lesions detected in 30 out of 33 individuals. While the proximal femur was affected in only nine individuals, X-ray of the proximal femur and ilium detected all individuals with postcranial evidence of metastatic disease. Skeletal distribution of metastases provides no clue to the location of origin or histological subtype of the cancer. A survey of archeological human remains for metastatic cancer requires radiological examination. Such skeletal surveys should X-ray at least the ilia and femora.
Identifier
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<a href="http://doi.org/10.1002/ajpa.1330960404" target="_blank" rel="noreferrer noopener">10.1002/ajpa.1330960404</a>
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Journal Article
2001
Anticancer research
Cancer
defleshed bones
erosive arthritis
Journal Article
lesions
Metastasis
metastasizing carcinoma
oncology
Rothschild B M
Rothschild C
skeletal pathology
X-Ray
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/ajpa.1330960404" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ajpa.1330960404</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
357-363
Issue
4
Volume
96
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
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Title
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COMPARISON OF RADIOLOGIC AND GROSS EXAMINATION FOR DETECTION OF CANCER IN DEFLESHED SKELETONS
Publisher
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American Journal of Physical Anthropology
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-04
Subject
The topic of the resource
Anthropology; bones; cancer; erosive arthritis; Evolutionary Biology; metastasis; metastasizing carcinoma; skeletal pathology; X-ray
Creator
An entity primarily responsible for making the resource
Rothschild B M; Rothschild C
Description
An account of the resource
The reliability of visual examination of defleshed bones was assessed for detection of postcranial metastatic disease in individuals known to have had cancer. This was compared with standard clinical radiologic techniques. The skeletons of 128 diagnosed cancer patients from an early 20th century autopsied skeletal collection (Hamann-Todd Collection) were examined. Radiologic examination detected evidence of metastatic disease in 33 individuals, compared to 11 by visual examination of the postcranial skeletons. Four of these cases were detected by both techniques. Elastic lesions were most commonly overlooked on visual examination, because they were localized to trabecular (internal bone) structures. The ilium was the most commonly affected bone, with lyric or blastic lesions detected in 30 of 33 individuals. While the proximal femur was affected in only nine individuals, x-ray of the proximal femur and ilium detected all individuals with postcranial evidence of metastatic disease. Skeletal distribution of metastases provides no clue to the location of origin or histologic subtype of the cancer. Survey of archeological human remains for metastatic cancer requires radiologic examination. Such skeletal surveys should x-ray at least the ilia and femora. (C) 1995 Wiley-Liss, Inc.
Identifier
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<a href="http://doi.org/10.1002/ajpa.1330960404" target="_blank" rel="noreferrer noopener">10.1002/ajpa.1330960404</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1995
American journal of physical anthropology
Anthropology
Bones
Cancer
erosive arthritis
Evolutionary Biology
Journal Article
Metastasis
metastasizing carcinoma
Rothschild B M
Rothschild C
skeletal pathology
X-Ray
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
267–274
Issue
3
Volume
12
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Inflammatory sacroiliac joint pathology: evaluation of radiologic assessment techniques.
Publisher
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Clinical and experimental rheumatology
Date
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1994
1994-06
Subject
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Humans; Sensitivity and Specificity; False Positive Reactions; Tomography; Osteoarthritis/diagnosis/diagnostic imaging/*pathology; Sacroiliac Joint/*diagnostic imaging/*pathology; X-Ray Computed; X-Ray
Creator
An entity primarily responsible for making the resource
Rothschild B M; Poteat G B; Williams E; Crawford W L
Description
An account of the resource
Recognition of sacroiliac disease has been integral to arthritis diagnostic approaches. However, intra- and inter-observer variation have been recognized as limiting factors in radiologic assessment of the sacroiliac joint. The assumption that such irregularly shaped joints can be radiologically assessed of the sacroiliac joint. The assumption that such irregularly shaped joints can be radiologically assessed has not actually been rigorously evaluated. Direct arthroscopic visualization of the joints was therefore used as a standard against which to assess the validity of routine radiologic views, stereo-radiology, tomography and computed tomography, in the analysis of a group of sacroiliac joints drawn from the Todd Collection (Cleveland Museum of Natural History). The most sensitive techniques for the recognition of erosions or fusion are 15 degree angulation and stereo, but the frequency of false positives makes the technique of questionable clinical utility. While sensitivity for joint space narrowing is high with several techniques (30 degree anterior-posterior or posterior-anterior projections and tomograms), specificity is still poor, with a high rate of false positives. Fulfillment of the New York Criteria for sacroiliac disease is especially insensitive and non-specific. Radiologic techniques therefore have major limitations for the assessment of sacroiliac disease and greater reliance on clinical acumen is required for patient categorization.
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
Clinical and experimental rheumatology
Crawford W L
False Positive Reactions
Humans
Osteoarthritis/diagnosis/diagnostic imaging/*pathology
Poteat G B
Rothschild B M
Sacroiliac Joint/*diagnostic imaging/*pathology
Sensitivity and Specificity
Tomography
Williams E
X-Ray
X-Ray Computed