1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1007/s10162-018-00690-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s10162-018-00690-3</a> Pages 653–668 Issue 6 Volume 19 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma. Publisher An entity responsible for making the resource available Journal of the Association for Research in Otolaryngology : JARO Date A point or period of time associated with an event in the lifecycle of the resource 2018 2018-12 Subject The topic of the resource calcium channel; hair cells; noise-induced hearing loss; spiral ganglion neurons; Stephania tetrandra; synapse; Tetrandrine Creator An entity primarily responsible for making the resource Yu Yan; Hu Bing; Bao Jianxin; Mulvany Jessica; Bielefeld Eric; Harrison Ryan T; Neton Sarah A; Thirumala Partha; Chen Yingying; Lei Debin; Qiu Ziyu; Zheng Qingyin; Ren Jihao; Perez-Flores Maria Cristina; Yamoah Ebenezer N; Salehi Pezhman Description An account of the resource Noise is the most common occupational and environmental hazard, and noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit. Although therapeutics that target the free-radical pathway have shown promise, none of these compounds is currently approved against NIHL by the United States Food and Drug Administration. The present study has demonstrated that tetrandrine (TET), a traditional Chinese medicinal alkaloid and the main chemical isolate of the Stephania tetrandra S. Moore herb, significantly attenuated NIHL in CBA/CaJ mice. TET is known to exert antihypertensive and antiarrhythmic effects through the blocking of calcium channels. Whole-cell patch-clamp recording from adult spiral ganglion neurons showed that TET blocked the transient Ca(2+) current in a dose-dependent manner and the half-blocking concentration was 0.6 + 0.1 muM. Consistent with previous findings that modulations of calcium-based signaling pathways have both prophylactic and therapeutic effects against neural trauma, NIHL was significantly diminished by TET administration. Importantly, TET has a long-lasting protective effect after noise exposure (48 weeks) in comparison to 2 weeks after noise exposure. The otoprotective effects of TET were achieved mainly by preventing outer hair cell damage and synapse loss between inner hair cells and spiral ganglion neurons. Thus, our data indicate that TET has great potential in the prevention and treatment of NIHL. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1007/s10162-018-00690-3" target="_blank" rel="noreferrer noopener">10.1007/s10162-018-00690-3</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2018 Bao Jianxin Bielefeld Eric calcium channel Chen Yingying Department of Anatomy & Neurobiology Hair Cells Harrison Ryan T Hu Bing Journal of the Association for Research in Otolaryngology : JARO Lei Debin Mulvany Jessica NEOMED College of Medicine Neton Sarah A Noise-induced hearing loss Perez-Flores Maria Cristina Qiu Ziyu Ren Jihao Salehi Pezhman spiral ganglion neurons Stephania tetrandra synapse Tetrandrine Thirumala Partha Yamoah Ebenezer N Yu Yan Zheng Qingyin