1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ajog.2003.09.074" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ajog.2003.09.074</a>
Pages
340–345
Issue
1
Volume
191
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Stimulation of distal airspace fluid clearance in guinea pigs involves bumetanide-sensitive ion transport.
Publisher
An entity responsible for making the resource available
American journal of obstetrics and gynecology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-07
Subject
The topic of the resource
*Ion Transport; Absorption; Adrenergic; Adrenergic beta-Antagonists/pharmacology; Animals; beta/physiology; Body Fluids/*metabolism; Bumetanide/*pharmacology; Diuretics/*pharmacology; Epinephrine/blood; Epithelium; Fetus/metabolism; Gestational Age; Guinea Pigs; Lung/*embryology/metabolism; Newborn; Propranolol/pharmacology; Receptors
Creator
An entity primarily responsible for making the resource
Ye Xin; Norlin Andreas; Folkesson Hans G
Description
An account of the resource
OBJECTIVE: This study was undertaken to test the hypothesis that beta-adrenoceptor stimulation of fetal lung fluid absorption in near-term guinea pig fetuses involves bumetanide-sensitive ion transport. STUDY DESIGN: Fetuses were obtained from timed-pregnant guinea pigs at 61 to 69 days' gestation with and without oxytocin-induced preterm labor. The fetuses were placed on continuous positive airway pressure oxygenation, and an isosmolar 5% albumin solution was instilled into the lungs. Distal airspace fluid clearance was measured over 1 hour from the increase in distal airspace protein concentration as fluid was reabsorbed with and without the Cl(-) transport inhibitor bumetanide. RESULTS: Fetal lungs began to absorb distal airspace fluid at 64 to 66 days' gestation, and at birth, distal airspace fluid clearance rapidly quadrupled. Labor induction by oxytocin stimulated distal airspace fluid clearance. Distal airspace fluid clearance, when present, was sensitive to propranolol-inhibition and depended on beta-adrenoceptor stimulation. Fluid secretion at 61 days' gestation was reduced by bumetanide instillation. Bumetanide addition was only inhibitory when distal airspace fluid clearance was propranolol-sensitive. CONCLUSION: Beta-adrenoceptor stimulation from endogenous fetal epinephrine increased fetal distal airspace fluid clearance and involved bumetanide-sensitive ion transport.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ajog.2003.09.074" target="_blank" rel="noreferrer noopener">10.1016/j.ajog.2003.09.074</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Ion Transport
2004
Absorption
Adrenergic
Adrenergic beta-Antagonists/pharmacology
American journal of obstetrics and gynecology
Animals
beta/physiology
Body Fluids/*metabolism
Bumetanide/*pharmacology
Diuretics/*pharmacology
Epinephrine/blood
Epithelium
Fetus/metabolism
Folkesson Hans G
Gestational Age
Guinea Pigs
Lung/*embryology/metabolism
Newborn
Norlin Andreas
Propranolol/pharmacology
Receptors
Ye Xin
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.00256.2004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00256.2004</a>
Pages
L1029–1038
Issue
6
Volume
289
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Oxytocin-induced labor augments IL-1beta-stimulated lung fluid absorption in fetal guinea pig lungs.
Publisher
An entity responsible for making the resource available
American journal of physiology. Lung cellular and molecular physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-12
Subject
The topic of the resource
*Labor; Absorption/drug effects; Amiloride/administration & dosage; Animals; Enzyme Activation/drug effects; Enzyme Inhibitors/administration & dosage; Epinephrine/metabolism; Extravascular Lung Water/*metabolism; Female; Fetal Organ Maturity/drug effects; Fetus/metabolism; Guinea Pigs; Hydrocortisone/metabolism; Induced; Interleukin-1/*administration & dosage/metabolism; Ion Transport/drug effects; Lung/*embryology; Maternal-Fetal Exchange/drug effects; Metyrapone/administration & dosage; Oxytocics/*administration & dosage; Oxytocin/*administration & dosage; Pregnancy; Propranolol/administration & dosage; Sodium Channel Blockers/administration & dosage; Sodium-Potassium-Chloride Symporters/metabolism; Vasodilator Agents/administration & dosage
Creator
An entity primarily responsible for making the resource
Nair Prem K; Li Tianbo; Bhattacharjee Reshma; Ye Xin; Folkesson Hans G
Description
An account of the resource
We tested the hypothesis that oxytocin-induced labor augmented
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.00256.2004" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00256.2004</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Labor
2005
Absorption/drug effects
American journal of physiology. Lung cellular and molecular physiology
Amiloride/administration & dosage
Animals
Bhattacharjee Reshma
Enzyme Activation/drug effects
Enzyme Inhibitors/administration & dosage
Epinephrine/metabolism
Extravascular Lung Water/*metabolism
Female
Fetal Organ Maturity/drug effects
Fetus/metabolism
Folkesson Hans G
Guinea Pigs
Hydrocortisone/metabolism
Induced
Interleukin-1/*administration & dosage/metabolism
Ion Transport/drug effects
Li Tianbo
Lung/*embryology
Maternal-Fetal Exchange/drug effects
Metyrapone/administration & dosage
Nair Prem K
Oxytocics/*administration & dosage
Oxytocin/*administration & dosage
Pregnancy
Propranolol/administration & dosage
Sodium Channel Blockers/administration & dosage
Sodium-Potassium-Chloride Symporters/metabolism
Vasodilator Agents/administration & dosage
Ye Xin
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.00214.2003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00214.2003</a>
Pages
L756–766
Issue
4
Volume
286
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
IL-1beta stimulates alveolar fluid absorption in fetal guinea pig lungs via the hypothalamus-pituitary-adrenal gland axis.
Publisher
An entity responsible for making the resource available
American journal of physiology. Lung cellular and molecular physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-04
Subject
The topic of the resource
Adrenocorticotropic Hormone/blood; Animals; Epinephrine/blood; Epithelial Sodium Channels; Extravascular Lung Water/*metabolism; Female; Guinea Pigs; Hydrocortisone/blood; Hypothalamo-Hypophyseal System/*physiology; Interleukin-1/blood/*pharmacology; Norepinephrine/blood; Pituitary-Adrenal System/*physiology; Pregnancy; Pulmonary Alveoli/*drug effects/embryology/*metabolism; Sodium Channels/metabolism; Sodium-Potassium-Exchanging ATPase/metabolism
Creator
An entity primarily responsible for making the resource
Ye Xin; Acharya Reshma; Herbert Jonathan B; Hamilton Sarah E; Folkesson Hans G
Description
An account of the resource
We tested the hypothesis that interleukin (IL)-1beta-induced cortisol synthesis stimulates alveolar fluid clearance in preterm fetuses. IL-1beta was administered subcutaneously daily to timed-pregnant guinea pigs for 3 days with and without simultaneous cortisol synthesis inhibition by metyrapone. Fetuses were obtained by abdominal hysterotomy at 61 and 68 days gestation and instilled with isosmolar 5% albumin in the lungs, and alveolar fluid movement was measured over 1 h from the change in alveolar protein concentration. Alveolar fluid clearance was induced at 61 days gestation and stimulated at 68 days gestation by IL-1beta, which both were attenuated by cortisol synthesis inhibition. Plasma ACTH and cortisol concentrations were increased by IL-1beta at both gestational ages, and metyrapone reduced cortisol concentrations. IL-1beta was mostly low or undetectable in both fetal and maternal blood. Prenatal alveolar fluid clearance, when present as well as IL-1beta induced, was always propranolol and amiloride sensitive, suggesting that beta-adrenoceptor stimulation and amiloride-sensitive Na+ channels were critical for fluid absorption. IL-1beta increased lung beta-adrenoceptor density at gestation day 61, and cortisol synthesis inhibition attenuated the increased beta-adrenoceptor density. Epithelial Na+ channel and Na+-K+-ATPase subunit expressions were both increased by IL-1beta and attenuated by cortisol synthesis inhibition. These results may explain why babies delivered preterm after intrauterine inflammation have a reduced risk of developing severe respiratory distress.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.00214.2003" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00214.2003</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
Acharya Reshma
Adrenocorticotropic Hormone/blood
American journal of physiology. Lung cellular and molecular physiology
Animals
Epinephrine/blood
Epithelial Sodium Channels
Extravascular Lung Water/*metabolism
Female
Folkesson Hans G
Guinea Pigs
Hamilton Sarah E
Herbert Jonathan B
Hydrocortisone/blood
Hypothalamo-Hypophyseal System/*physiology
Interleukin-1/blood/*pharmacology
Norepinephrine/blood
Pituitary-Adrenal System/*physiology
Pregnancy
Pulmonary Alveoli/*drug effects/embryology/*metabolism
Sodium Channels/metabolism
Sodium-Potassium-Exchanging ATPase/metabolism
Ye Xin