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<a href="http://doi.org/10.1007/978-3-030-22254-3_6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/978-3-030-22254-3_6</a>
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Pages
73
ISSN
3-030-22254-3
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Title
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Contributing Roles of CYP2E1 and Other Cytochrome P450 Isoforms in Alcohol-Related Tissue Injury and Carcinogenesis
Publisher
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Human Cell Transformation : Advances In Cell Models For The Study Of Cancer And Aging
Date
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2019
1905-07
Subject
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inflammation; Oxidative stress; Cancer; CYP2E1; Cell Biology; Oncology; Alcohol; Acetaldehyde; Biomedical and Life Sciences; Cancer Research; DNA mutation; Life Sciences
Creator
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Byoung-Joon Song; Mohamed A Abdelmegeed; Young-Eun Cho; Mohammed Akbar; Johng S Rhim; Min-Kyung Song; James P Hardwick
Description
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The purpose of this review is to briefly summarize the roles of alcohol (ethanol) and related compounds in promoting cancer and inflammatory injury in many tissues. Long-term chronic heavy alcohol exposure is known to increase the chances of inflammation, oxidative DNA damage, and cancer development in many organs. The rates of alcohol-mediated organ damage and cancer risks are significantly elevated in the presence of co-morbidity factors such as poor nutrition, unhealthy diets, smoking, infection with bacteria or viruses, and exposure to pro-carcinogens. Chronic ingestion of alcohol and its metabolite acetaldehyde may initiate and/or promote the development of cancer in the liver, oral cavity, esophagus, stomach, gastrointestinal tract, pancreas, prostate, and female breast. In this chapter, we summarize the important roles of ethanol/acetaldehyde in promoting inflammatory injury and carcinogenesis in several tissues. We also review the updated roles of the ethanol-inducible cytochrome P450-2E1 (CYP2E1) and other cytochrome P450 isozymes in the metabolism of various potentially toxic substrates, and consequent toxicities, including carcinogenesis in different tissues. We also briefly describe the potential implications of endogenous ethanol produced by gut bacteria, as frequently observed in the experimental models and patients of nonalcoholic fatty liver disease, in promoting DNA mutation and cancer development in the liver and other tissues, including the gastrointestinal tract.
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<a href="http://doi.org/10.1007/978-3-030-22254-3_6" target="_blank" rel="noreferrer noopener">10.1007/978-3-030-22254-3_6</a>
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Journal Article
2019
acetaldehyde
Alcohol
Biomedical and Life Sciences
Byoung-Joon Song
Cancer
Cancer Research
Cell Biology
CYP2E1
Department of Integrative Medical Sciences
DNA mutation
Human Cell Transformation : Advances In Cell Models For The Study Of Cancer And Aging
Inflammation
James P Hardwick
Johng S Rhim
Journal Article
Life sciences
Min-Kyung Song
Mohamed A Abdelmegeed
Mohammed Akbar
NEOMED College of Medicine
November 2019 Update
oncology
Oxidative Stress
Young-Eun Cho