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Text
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URL Address
<a href="http://doi.org/10.2174/156720507783018226" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/156720507783018226</a>
Pages
522–536
Issue
5
Volume
4
Dublin Core
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Title
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Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties.
Publisher
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Current Alzheimer research
Date
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2007
2007-12
Subject
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Humans; Animals; Drug Design; Alzheimer Disease/pathology/*prevention & control; Central Nervous System/chemistry/*drug effects/metabolism; Neuroprotective Agents/*chemistry/pharmacology/*therapeutic use; Neurotransmitter Agents/chemistry/*metabolism; Biological; Models
Creator
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Van der Schyf Cornelis J; Mandel Silvia; Geldenhuys Werner J; Amit Tamar; Avramovich Yael; Zheng Hailin; Fridkin Mati; Gal Shunit; Weinreb Orly; Bar Am Orit; Sagi Yotam; Youdim Moussa B H
Description
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Traditionally, drug design programs are focused on optimizing the specificity of lead compounds against a carefully selected drug target. Disappointingly, this approach to discover a "magic bullet" drug has not met with the expected success for CNS disorders. Transcriptomics and proteomic profiling of neurodegenerative diseases have indicated that they are poly-etiological in origin and that the processes leading to neuronal death are multifactorial. An emerging concept is the design of drug ligands that modulate multiple drug targets identified for a particular disease. In this review we explore some examples of multifunctional drugs which may be useful in the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.
Identifier
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<a href="http://doi.org/10.2174/156720507783018226" target="_blank" rel="noreferrer noopener">10.2174/156720507783018226</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Alzheimer Disease/pathology/*prevention & control
Amit Tamar
Animals
Avramovich Yael
Bar Am Orit
Biological
Central Nervous System/chemistry/*drug effects/metabolism
Current Alzheimer research
Drug Design
Fridkin Mati
Gal Shunit
Geldenhuys Werner J
Humans
Mandel Silvia
Models
Neuroprotective Agents/*chemistry/pharmacology/*therapeutic use
Neurotransmitter Agents/chemistry/*metabolism
Sagi Yotam
Van der Schyf Cornelis J
Weinreb Orly
Youdim Moussa B H
Zheng Hailin