1
40
4
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/978-3-030-22254-3_6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/978-3-030-22254-3_6</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
73
ISSN
3-030-22254-3
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<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1007/978-3-030-22254-3_6" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1007/978-3-030-22254-3_6</a>
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Dublin Core
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Title
A name given to the resource
Contributing Roles of CYP2E1 and Other Cytochrome P450 Isoforms in Alcohol-Related Tissue Injury and Carcinogenesis
Publisher
An entity responsible for making the resource available
Human Cell Transformation : Advances In Cell Models For The Study Of Cancer And Aging
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
1905-07
Subject
The topic of the resource
inflammation; Oxidative stress; Cancer; CYP2E1; Cell Biology; Oncology; Alcohol; Acetaldehyde; Biomedical and Life Sciences; Cancer Research; DNA mutation; Life Sciences
Creator
An entity primarily responsible for making the resource
Byoung-Joon Song; Mohamed A Abdelmegeed; Young-Eun Cho; Mohammed Akbar; Johng S Rhim; Min-Kyung Song; James P Hardwick
Description
An account of the resource
The purpose of this review is to briefly summarize the roles of alcohol (ethanol) and related compounds in promoting cancer and inflammatory injury in many tissues. Long-term chronic heavy alcohol exposure is known to increase the chances of inflammation, oxidative DNA damage, and cancer development in many organs. The rates of alcohol-mediated organ damage and cancer risks are significantly elevated in the presence of co-morbidity factors such as poor nutrition, unhealthy diets, smoking, infection with bacteria or viruses, and exposure to pro-carcinogens. Chronic ingestion of alcohol and its metabolite acetaldehyde may initiate and/or promote the development of cancer in the liver, oral cavity, esophagus, stomach, gastrointestinal tract, pancreas, prostate, and female breast. In this chapter, we summarize the important roles of ethanol/acetaldehyde in promoting inflammatory injury and carcinogenesis in several tissues. We also review the updated roles of the ethanol-inducible cytochrome P450-2E1 (CYP2E1) and other cytochrome P450 isozymes in the metabolism of various potentially toxic substrates, and consequent toxicities, including carcinogenesis in different tissues. We also briefly describe the potential implications of endogenous ethanol produced by gut bacteria, as frequently observed in the experimental models and patients of nonalcoholic fatty liver disease, in promoting DNA mutation and cancer development in the liver and other tissues, including the gastrointestinal tract.
Identifier
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<a href="http://doi.org/10.1007/978-3-030-22254-3_6" target="_blank" rel="noreferrer noopener">10.1007/978-3-030-22254-3_6</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
acetaldehyde
Alcohol
Biomedical and Life Sciences
Byoung-Joon Song
Cancer
Cancer Research
Cell Biology
CYP2E1
Department of Integrative Medical Sciences
DNA mutation
Human Cell Transformation : Advances In Cell Models For The Study Of Cancer And Aging
Inflammation
James P Hardwick
Johng S Rhim
Journal Article
Life sciences
Min-Kyung Song
Mohamed A Abdelmegeed
Mohammed Akbar
NEOMED College of Medicine
November 2019 Update
oncology
Oxidative Stress
Young-Eun Cho
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1006/abbi.2000.2119" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/abbi.2000.2119</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
81-87
Issue
1
Volume
384
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Dublin Core
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Title
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Cytochrome P450 2e1 (cyp2e1)-dependent Production Of A 37-kda Acetaldehyde-protein Adduct In The Rat Liver
Publisher
An entity responsible for making the resource available
Archives of Biochemistry and Biophysics
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-12
Subject
The topic of the resource
acetaldehyde; acetaldehyde-protein adduct; alcohol; alcohol metabolism; aldehyde; Biochemistry & Molecular Biology; Biophysics; CYP2E1; CYP2E1 inhibitor; dehydrogenase; ethanol; expression; hepatocytes; hydroxyethyl radical adducts; induction; lipid-peroxidation; plasma-membrane
Creator
An entity primarily responsible for making the resource
Jeong K S; Soh Y; Jeng J; Felder M R; Hardwick J P; Song B J
Description
An account of the resource
Ethanol-inducible cytochrome P450 2E1 (CYP2E1) has been shown to be involved in the metabolism of both ethanol and acetaldehyde, Acetaldehyde, produced from ethanol metabolism, is highly reactive and can form various protein adducts, In this study, we investigated the role of CYP2E1 in the production of a 37-kDa acetaldehyde-protein adduct, Rats were pair-fed an isocaloric control or an alcohol liquid diet with and without cotreatment of YH439, an inhibitor of CYP2E1 gene transcription, for 4 weeks. The soluble proteins from rat livers of each group were separated on SDS-polyacrylamide gels followed by immunoblot analysis using specific antibodies against the 37-kDa protein acetaldehyde adduct, In addition, catalytic activities of the enzymes involved in alcohol and acetaldehyde metabolism were measured and compared with the adduct level, Immunoblot analysis revealed that the 37-kDa adduct, absent in the pair-fed control, was evident in alcohol-fed rats but markedly reduced by YH439 treatment. Immunohistochemical analysis also showed that the 37-kDa adduct is predominantly localized in the pericentral region of the liver where CYP2E1 protein is mainly expressed. This staining disappeared in the pericentral region after YH439 treatment. The levels of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase isozymes were unchanged after YH439 treatment. However, the level of the 37-kDa protein adduct positively correlated with the hepatic content of P4502E1, These data indicate that the 37-kDa adduct could be produced by CYP2E1-mediated ethanol metabolism in addition to the ADH-dependent formation. (C) 2000 Academic Press.
Identifier
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<a href="http://doi.org/10.1006/abbi.2000.2119" target="_blank" rel="noreferrer noopener">10.1006/abbi.2000.2119</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2000
acetaldehyde
acetaldehyde-protein adduct
Alcohol
alcohol metabolism
aldehyde
Archives of biochemistry and biophysics
Biochemistry & Molecular Biology
Biophysics
CYP2E1
CYP2E1 inhibitor
dehydrogenase
ETHANOL
expression
Felder M R
Hardwick J P
hepatocytes
hydroxyethyl radical adducts
induction
Jeng J
Jeong K S
Journal Article or Conference Abstract Publication
lipid-peroxidation
plasma-membrane
Soh Y
Song B J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1530-0277.1993.tb05672.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1530-0277.1993.tb05672.x</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1107-1111
Issue
5
Volume
17
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Dublin Core
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Title
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Improved Separation Of Acetaldehyde-induced Hemoglobin
Publisher
An entity responsible for making the resource available
Alcoholism-Clinical and Experimental Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-10
Subject
The topic of the resource
acetaldehyde; adducts; alcoholism; biological marker; chromatography (hplc); hemoglobin; high-pressure liquid; liquid-chromatography; Substance Abuse
Creator
An entity primarily responsible for making the resource
Hazelett S E; Liebelt R A; Truitt E B
Description
An account of the resource
A fast-eluting minor variant of hemoglobin A, designated as HbA1-AcH, appears elevated after the incubation of red blood cell hemolysates with acetaldehyde (AcH) and has been proposed as a diagnostic marker for alcoholism or as an indicator for heavy drinking. We have developed an improved HPLC separation of this peak and others elevated by AcH using a polyaspartic acid column (PolyCAT A, PolyLC, Inc.) and a nonlinear buffer gradient with pH changes from 6.6 to 6.8. Saline-washed red blood cells were treated with sodium acetate buffer (pH 5.5) to remove unstable Schiff bases, and then hemolyzed by addition of an equal volume of H2O and 0.4 volumes of CCl4. HbA1-AcH and several others, including two peaks in the HbA1a+b cluster, Hb Pre-A1c, and HbA1d3 were significantly increased by AcH incubation, and the changes were only partially reversible with time. Improved resolution of these peaks allows more accurate quantitation of AcH adducts of hemoglobin.
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<a href="http://doi.org/10.1111/j.1530-0277.1993.tb05672.x" target="_blank" rel="noreferrer noopener">10.1111/j.1530-0277.1993.tb05672.x</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1993
acetaldehyde
adducts
alcoholism
Alcoholism-Clinical and Experimental Research
biological marker
chromatography (hplc)
Department of Family & Community Medicine
Hazelett S E
hemoglobin
high-pressure liquid
Journal Article or Conference Abstract Publication
Liebelt R A
liquid-chromatography
NEOMED College of Medicine
Substance Abuse
Truitt E B
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00000374-199811000-00029" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00000374-199811000-00029</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1813-1819
Issue
8
Volume
22
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Evaluation Of Acetaldehyde-modified Hemoglobin And Other Markers Of Chronic Heavy Alcohol Use: Effects Of Gender And Hemoglobin Concentration
Publisher
An entity responsible for making the resource available
Alcoholism-Clinical and Experimental Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-11
Subject
The topic of the resource
abuse; acetaldehyde; adducts; alcohol; carbohydrate-deficient transferrin; cation-exchange chromatography; consumption; drinking; gamma-glutamyl-transferase; gender; hemoglobin; HPLC; liquid-chromatography; liver-disease; serum; Substance Abuse
Creator
An entity primarily responsible for making the resource
Hazelett S E; Liebelt R A; Brown W J; Androulakakis V; Jarjoura D; Truitt E B
Description
An account of the resource
The present study examined whether measurement of hemoglobin-acetaldehyde (HbA1-AcH) using an improved methodology may be useful as a biological marker of alcohol abuse. Red blood cell hemolysates of 182 patients consecutively admitted to the drug and alcohol treatment unit of our institution were analyzed for HbA1-AcH concentration using cation exchange HPLC. Mean HbA1-AcH of those who claimed to drink greater than or equal to 6 drinks/day [mean = 0.055 (% total hemoglobin), SD = 0.051] was significantly higher than the mean of those who drank <6 drinks/day (mean = 0.026, SD = 0.0174). The greatest sum of sensitivity (67%) and specificity (77%) came with a cut-score of 0.030 area% of total hemoglobin. A cut-score of 0.080 produced a 100% specificity, but lowered the sensitivity to 20%. The Pearson product moment correlation (r) between HbA1-AcH and reported drinks per day was r = 0.30 (p < 0.001). There was no significant difference in the association of HbA1-AcH end reported drinking between males and females, and the small difference observed was shown to be entirely associated with differences in hemoglobin levels between the sexes. Cocaine use did not significantly alter the correlation between reported drinking and HbA1-AcH levels. Hemoglobin levels were shown to have a significant correlation with HbA1-AcH independent of drinking. HbA1-AcH was shown to have a better sensitivity and specificity than gamma-glutamyltransferase, ALT, AST, or mean corpuscular volume in this population. The results suggest that HbA1-AcH may be a useful marker to help detect alcohol abuse, especially in populations where other markers have been shown to fail.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00000374-199811000-00029" target="_blank" rel="noreferrer noopener">10.1097/00000374-199811000-00029</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1998
abuse
acetaldehyde
adducts
Alcohol
Alcoholism-Clinical and Experimental Research
Androulakakis V
Brown W J
carbohydrate-deficient transferrin
cation-exchange chromatography
consumption
Department of Family & Community Medicine
drinking
gamma-glutamyl-transferase
Gender
Hazelett S E
hemoglobin
HPLC
Jarjoura D
Journal Article or Conference Abstract Publication
Liebelt R A
liquid-chromatography
liver-disease
NEOMED College of Medicine
serum
Substance Abuse
Truitt E B