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Text
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URL Address
<a href="http://doi.org/10.1001/archneur.1993.00540010086023" target="_blank" rel="noreferrer noopener">http://doi.org/10.1001/archneur.1993.00540010086023</a>
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Pages
92-97
Issue
1
Volume
50
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Title
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Memory Evaluation In Alzheimers-disease - Caregivers Appraisals And Objective Testing
Publisher
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Archives of Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-01
Subject
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adulthood; cerad; complaints; consortium; dementia; establish; neuropsychological assessment; Neurosciences & Neurology; questionnaires; rating-scale; relatives
Creator
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Koss E; Patterson M B; Ownby R; Stuckey J C; Whitehouse P J
Description
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Objectives.-To evaluate if caregivers are reliable informants concerning memory deficits in patients with Alzheimer's disease (AD). Design.-Responses of caregivers of patients with probable AD and responses of healthy control subjects on a standardized memory questionnaire were compared with objective measures of cognition (Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery) and with clinical estimates of activities of daily living, depression, and psychopathology (Consortium to Establish a Registry for Alzheimer's Disease [CERAD] clinical assessment battery) using the Self-report Memory Questionnaire. Setting.-A federally funded AD research center. Subjects.-The referred sample included 117 patients with probable AD, their informants, and 41 healthy control subjects age-matched to the patients. Patients and control subjects were between the ages of 58 and 85 years, had between 9 and 19 years of education, and were in good health. Exclusions.-Patients who did not meet NINCDS-ADRDA criteria of probable AD. Main Outcome Measure.-The optimal number of questionnaire items yielding the best combination of sensitivity and specificity. Results.-An abbreviated version of the scale, renamed the Short-Memory Questionnaire, had excellent specificity and sensitivity for identifying dementia. Positive and negative predictive values were 63.5% and near 100%, respectively. The Short-Memory Questionnaire showed good reliability, internal consistency, and external validity. Caregiver appraisals of memory deficits significantly correlated with objective measures of memory and also with generalized cognitive dysfunction. Conclusions.-Caregivers of patients with AD are reliable informants of their relatives' deficits. The Short-Memory Questionnaire is an easily administered, informant-based scale that may be useful in clinical settings or epidemiologic studies to screen out persons with memory difficulties.
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<a href="http://doi.org/10.1001/archneur.1993.00540010086023" target="_blank" rel="noreferrer noopener">10.1001/archneur.1993.00540010086023</a>
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Journal Article or Conference Abstract Publication
1993
adulthood
Archives of Neurology
cerad
complaints
consortium
dementia
establish
Journal Article or Conference Abstract Publication
Koss E
neuropsychological assessment
Neurosciences & Neurology
Ownby R
Patterson M B
Questionnaires
rating-scale
relatives
Stuckey J C
Whitehouse P J