1
40
6
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/nyas.13156" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/nyas.13156</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
80-86
Volume
1378
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Novel Approaches To Mitigating Parathion Toxicity: Targeting Cytochrome P450-mediated Metabolism With Menadione
Publisher
An entity responsible for making the resource available
Countermeasures against Chemical Threats Ii
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016
Subject
The topic of the resource
acetylcholinesterase; agents; chlorcyclizine; cytotoxicity; enzyme; inhibition; menadione; organophosphate exposure; organophosphorus; paraoxon; parathion; pesticides; reactivators; redox cycling; reductase; Super oxide
Creator
An entity primarily responsible for making the resource
Jan Y H; Richardson J R; Baker A A; Mishin V; Heck D E; Laskin D L; Laskin J D
Description
An account of the resource
Accidental or intentional exposures to parathion, an organophosphorus (OP) pesticide, can cause severe poisoning in humans. Parathion toxicity is dependent on its metabolism by the cytochrome P450 (CYP) system to paraoxon (diethyl 4-nitrophenyl phosphate), a highly poisonous nerve agent and potent inhibitor of acetylcholinesterase. We have been investigating inhibitors of CYP-mediated bioactivation of OPs as a method of preventing or reversing progressive parathion toxicity. It is well recognized that NADPH-cytochrome P450 reductase, an enzyme required for the transfer of electrons to CYPs, mediates chemical redox cycling. In this process, the enzyme diverts electrons from CYPs to support chemical redox cycling, which results in inhibition of CYP-mediated biotransformation. Using menadione as the redox-cycling chemical, we discovered that this enzymatic reaction blocks metabolic activation of parathion in rat and human liver microsomes and in recombinant CYPs important to parathion metabolism, including CYP1A2, CYP2B6, and CYP3A4. Administration of menadione to rats reduces metabolism of parathion, as well as parathion-induced inhibition of brain cholinesterase activity. This resulted in inhibition of parathion neurotoxicity. Menadione has relatively low toxicity and is approved by the Food and Drug Administration for other indications. Its ability to block parathion metabolism makes it an attractive therapeutic candidate to mitigate parathion-induced neurotoxicity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/nyas.13156" target="_blank" rel="noreferrer noopener">10.1111/nyas.13156</a>
Format
The file format, physical medium, or dimensions of the resource
Book Chapter
2016
acetylcholinesterase
agents
Baker A A
Book Chapter
chlorcyclizine
Countermeasures against Chemical Threats Ii
cytotoxicity
enzyme
Heck D E
inhibition
Jan Y H
Laskin D L
Laskin J D
menadione
Mishin V
organophosphate exposure
organophosphorus
paraoxon
parathion
pesticides
reactivators
Redox cycling
reductase
Richardson J R
Super oxide
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1006/cbir.1993.1042" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/cbir.1993.1042</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1091-1105
Issue
12
Volume
17
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect Of Ethidium On The Morphology, Antiviral Activity And Subcellular-distribution Of Poly R(a-u)
Publisher
An entity responsible for making the resource available
Cell Biology International
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-12
Subject
The topic of the resource
agents; binding; Cell Biology; complex; delivery; dna; double-stranded-rna; human interferon; induction; inhibition; microscopy
Creator
An entity primarily responsible for making the resource
Jamison J M; Gilloteaux J J; Adrian M; Summers J L
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1006/cbir.1993.1042" target="_blank" rel="noreferrer noopener">10.1006/cbir.1993.1042</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1993
Adrian M
agents
Binding
Cell Biology
Cell biology international
complex
Delivery
DNA
double-stranded-rna
Gilloteaux J J
human interferon
induction
inhibition
Jamison J M
Journal Article or Conference Abstract Publication
Microscopy
Summers J L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00003246-199512000-00004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00003246-199512000-00004</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1962-1970
Issue
12
Volume
23
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Comparison Of Dopamine To Dobutamine And Norepinephrine For Oxygen Delivery And Uptake In Septic Shock
Publisher
An entity responsible for making the resource available
Critical Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-12
Subject
The topic of the resource
agents; cardiac-output; catecholamines; consumption; dobutamine; dopamine; General & Internal Medicine; hemodynamics; infusion; inotropic; intra-pulmonary shunt; lactic-acidosis; norepinephrine; oxygen consumption; septic shock; severe sepsis; skeletal-muscle; therapy; transport
Creator
An entity primarily responsible for making the resource
Hannemann L; Reinhart K; Grenzer O; Meierhellmann A; Bredle D L
Description
An account of the resource
Objectives: To test whether dopamine infusion improves oxygen delivery (D over dot O-2) and oxygen uptake (V over dot O-2) in hyperdynamic septic shock patients stabilized by adequate volume and dobutamine alone, or by the combination of dobutamine and norepinephrine. Design: Prospective clinical trial of two patient groups. Group 1 (n = 15) was stabilized with dobutamine, and group 2 (n = 10) was stabilized with dobutamine and norepinephrine. Setting: Intensive care unit in a university hospital. Patients: Twenty-five postoperative, hyperdynamic septic shock patients. Interventions: The stabilizing catecholamine infusion was replaced in a stepwise manner by dopamine to achieve a similar mean arterial pressure (dopamine doses: group 1, mean 22 +/- 15 mu g/kg/min [range 6 to 52]; and group 2, mean 57 +/- 41 mu g/kg/min [range 15 to 130]). Measurements and Main Results: A complete hemodynamic profile was performed with oxygen transport-related variables at baseline, after replacement by dopamine and after resetting to the original catecholamine infusion. The change to dopamine resulted in increases in cardiac index (group 1: 20% [p < .01]; group 2: 33% [p < .01]), and D over dot O-2 (group 1: 19% [p < .01]; group 2: 27% [p < .01]). However, V over dot O-2, whether directly measured from the respiratory gases or calculated by the cardiovascular Fick principle, did not change in both groups with dopamine, while the oxygen extraction ratio decreased significantly in both groups with dopamine. Heart rate, pulmonary artery occlusion pressure, and pulmonary shunt fraction all increased with dopamine, Pao(2) decreased, but oxygen saturation remained stable in both groups with dopamine. Conclusions: Short-term dopamine infusion in hyperdynamic septic shock patients, de. spite producing higher global D over dot O-2, was not superior to dobutamine or the combination of dobutamine and norepinephrine infusion.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00003246-199512000-00004" target="_blank" rel="noreferrer noopener">10.1097/00003246-199512000-00004</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1995
agents
Bredle D L
cardiac-output
catecholamines
consumption
Critical care medicine
dobutamine
Dopamine
General & Internal Medicine
Grenzer O
Hannemann L
Hemodynamics
infusion
inotropic
intra-pulmonary shunt
Journal Article or Conference Abstract Publication
lactic-acidosis
Meierhellmann A
Norepinephrine
Oxygen Consumption
Reinhart K
Septic shock
severe sepsis
skeletal-muscle
therapy
transport
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00003246-199703000-00005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00003246-199703000-00005</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
399-404
Issue
3
Volume
25
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Epinephrine impairs splanchnic perfusion in septic shock
Publisher
An entity responsible for making the resource available
Critical Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-03
Subject
The topic of the resource
sepsis; oxygen consumption; General & Internal Medicine; epinephrine; agents; septic shock; norepinephrine; oxygen delivery; critically ill patients; intramural ph; tissue oxygenation; blood flow; oxygen consumption; gastric-mucosal ph; indocyanine green; splanchnic; splanchnic oxygen delivery; dobutamine; hepatic blood-flow; splanchnic oxygen consumption; vasoactive
Creator
An entity primarily responsible for making the resource
MeierHellmann A; Reinhart K; Bredle D L; Specht M; Spies C D; Hannemann L
Description
An account of the resource
Objective: To assess the effects of epinephrine on splanchnic perfusion and splanchnic oxygen uptake in patients with septic shock. Design: Prospective, controlled trial. Setting: University hospital intensive care unit (ICU). Patients: Eight patients with septic shock, according to the criteria of the 1992 American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference, requiring treatment with vasopressors. Interventions: We compared in crossover design a 2-hr infusion of epinephrine with dobutamine plus norepinephrine in eight ICU patients with septic shock, Systemic and splanchnic hemodynamics and oxygen transport were measured before and during treatment with epinephrine. Measurements and Main Results: There was essentially no effect of epinephrine on the global parameters, except for increased lactate concentrations, There were marked effects on the regional variables; epinephrine caused lower splanchnic flow and oxygen uptake, lower mucosal pH, and higher hepatic vein lactate. Conclusion: We conclude that undesirable splanchnic effects on patients in whom that region is particularly fragile should be considered when using epinephrine for septic shock treatment.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00003246-199703000-00005" target="_blank" rel="noreferrer noopener">10.1097/00003246-199703000-00005</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1997
agents
blood flow
Bredle D L
Critical care medicine
Critically Ill Patients
dobutamine
Epinephrine
gastric-mucosal ph
General & Internal Medicine
Hannemann L
hepatic blood-flow
Indocyanine Green
intramural ph
Journal Article or Conference Abstract Publication
Meierhellmann A
Norepinephrine
Oxygen Consumption
oxygen delivery
Reinhart K
sepsis
Septic shock
Specht M
Spies C D
splanchnic
splanchnic oxygen consumption
splanchnic oxygen delivery
tissue oxygenation
vasoactive
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3810/pgm.2001.03.895" target="_blank" rel="noreferrer noopener">http://doi.org/10.3810/pgm.2001.03.895</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
93-94
Issue
3
Volume
109
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Necrobiosis lipoidica - Indolent plaques may signal diabetes
Publisher
An entity responsible for making the resource available
Postgraduate Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-03
Subject
The topic of the resource
General & Internal Medicine; agents
Creator
An entity primarily responsible for making the resource
Bello Y M; Phillips T J
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3810/pgm.2001.03.895" target="_blank" rel="noreferrer noopener">10.3810/pgm.2001.03.895</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2001
agents
Bello Y M
General & Internal Medicine
Journal Article or Conference Abstract Publication
Phillips T J
Postgraduate medicine
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/jm300100d" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/jm300100d</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
3425-3435
Issue
7
Volume
55
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Title
A name given to the resource
Identification of a Class of Novel Tubulin Inhibitors
Publisher
An entity responsible for making the resource available
Journal of Medicinal Chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-04
Subject
The topic of the resource
agents; analog jcc76; biological evaluation; breast-cancer cells; halichondrin-b; heat-shock proteins; hsp27 phosphorylation; in-vivo; nimesulide; nonsteroidal antiinflammatory drugs; Pharmacology & Pharmacy; tumor-cells
Creator
An entity primarily responsible for making the resource
Yi X; Zhong B; Smith K M; Geldenhuys W J; Feng Y; Pink J J; Dowlati A; Xu Y; Zhou A M; Su B
Description
An account of the resource
We previously developed a series of anticancer agents based on cyclooxygenase-2 (COX-2) inhibitor nimesulide as a lead compound. However, the molecular targets of these agents still remain unclear. In this study, we synthesized a biotinylated probe based on a representative molecule of the compound library and performed protein pull-down assays to purify the anticancer targets of the compound. Via proteomic approaches, the major proteins bound to the probe were identified to be tubulin and heat shock protein 27 (Hsp27), and the compound inhibited tubulin polymerization by binding at the colchicine domain. However, the tubulin inhibitory effect of the compound activated the Hsp27 phosphorylation and possibly overrode the direct Hsp27 inhibitory effects, which made it difficult to solely validate the Hsp27 target. Taken together, the compound was a dual ligand of tubulin and Hsp27, inhibited tubulin polymerization, and had the potential to be a class of new chemotherapeutic agents.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/jm300100d" target="_blank" rel="noreferrer noopener">10.1021/jm300100d</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2012
agents
analog jcc76
biological evaluation
breast-cancer cells
Dowlati A
Feng Y
Geldenhuys W J
halichondrin-b
Heat-Shock Proteins
hsp27 phosphorylation
in-vivo
Journal Article
Journal of medicinal chemistry
nimesulide
nonsteroidal antiinflammatory drugs
Pharmacology & Pharmacy
Pink J J
Smith K M
Su B
tumor-cells
Xu Y
Yi X
Zhong B
Zhou A M