1
40
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Text
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URL Address
<a href="http://doi.org/10.3389/fphar.2012.00035" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fphar.2012.00035</a>
Pages
35–35
Volume
3
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Regulation of aldo-keto reductases in human diseases.
Publisher
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Frontiers in pharmacology
Date
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2012
1905-07
Subject
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aldo-keto reductase; human disease; regulation; response element; transcription factor
Creator
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Chen Wei-Dong; Zhang Yanqiao
Description
An account of the resource
The aldo-keto reductases (AKRs) are a superfamily of NAD(P)H-linked oxidoreductases, which reduce aldehydes and ketones to their respective primary and secondary alcohols. AKR enzymes are increasingly being recognized to play an important role in the transformation and detoxification of aldehydes and ketones generated during drug detoxification and xenobiotic metabolism. Many transcription factors have been identified to regulate the expression of human AKR genes, which could have profound effects on the metabolism of endogenous mediators and detoxication of chemical carcinogens. This review summarizes the current knowledge on AKR regulation by transcription factors and other mediators in human diseases.
Identifier
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<a href="http://doi.org/10.3389/fphar.2012.00035" target="_blank" rel="noreferrer noopener">10.3389/fphar.2012.00035</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
aldo-keto reductase
Chen Wei-Dong
Frontiers in pharmacology
human disease
regulation
response element
transcription factor
Zhang Yanqiao
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1161/CIRCRESAHA.120.317715">http://doi.org/10.1161/CIRCRESAHA.120.317715</a></td>
</tr></tbody></table>
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Integrative Medical Sciences
Update Year & Number
Jan to Aug list 2021
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins.
Creator
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Ohanyan V;Raph SM;Dwenger MM;Hu X;Pucci T;Mack GD;Moore IJB;Chilian WM;Bhatnagar A;Nystoriak MA
Publisher
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Circulation Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-03-19
Description
An account of the resource
Voltage-gated potassium (Kv) channels in vascular smooth muscle are essential for coupling myocardial blood flow (MBF) with the metabolic demand of the heart. These channels consist of a transmembrane pore domain that associates with auxiliary Kvβ (voltage-gated potassium channel β)1 and Kvβ2 proteins, which differentially regulate Kv function in excitable cells. Nonetheless, the physiological role of Kvβ proteins in regulating vascular tone and metabolic hyperemia in the heart remains unknown.
Subject
The topic of the resource
To test the hypothesis that Kvβ proteins confer oxygen sensitivity to vascular tone and are required for regulating blood flow in the heart.
Identifier
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<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1161/CIRCRESAHA.120.317715">http://doi.org/10.1161/CIRCRESAHA.120.317715</a></td>
</tr></tbody></table>
Rights
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2021 American Heart Association, Inc
Format
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Journal Article
2021
aldo-keto reductase
Coronary Circulation
ion channel
Physiology
Potassium channel