1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
213-220
Issue
1
Volume
71
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Inhibition Of Phosphorylation Of Trkb And Trkc And Their Signal Transduction By Alpha(2)-macroglobulin
Publisher
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Journal of Neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-07
Subject
The topic of the resource
alpha(2)-macroglobulin; alpha(2)-macroglobulin; alpha(2)-macroglobulin; Alzheimer's disease; Biochemistry & Molecular Biology; cerebrospinal-fluid; dopaminergic-neurons; mitogen-activated protein kinases; nerve growth-factor; neurite outgrowth; Neurodegenerative diseases; Neurosciences & Neurology; neurotrophic factor; neurotrophins; phospholipase C-gamma 1; rat caudate-putamen; signal-transduction; tyrosine protein-kinase
Creator
An entity primarily responsible for making the resource
Hu Y Q; Koo P H
Description
An account of the resource
Monoamine-activated alpha(2)-macroglobulin (alpha(2)M) was shown to reduce the dopamine concentration in corpus striatum of adult rat brains and inhibit other neuronal functions in vivo and in vitro. As brain-derived neurotrophic factor, neurotrophin-4, and neurotrophin-3 are important neurotrophic factors for dopaminergic neurons, the effect of monoamine-activated alpha(2)M on signal transduction by trkB and trkC was investigated. The results show that monoamine-activated alpha(2)M binds to trkB and inhibits brain-derived neurotrophic factor/neurotrophin-4-promoted autophosphorylation of trkB in a dose-dependent manner in both trkB-expressing NIH3T3 (NIH3T3-trkB) and human neuroblastoma SH-SY5Y cells. Monoamine-activated alpha(2)M also blocks tyrosine phosphorylation of phospholipase C-gamma 1 and extracellular signal-regulated protein kinase(ERK)-1,which are key intracellular proteins involved in trkB signal transduction. Similarly, monoamine-activated alpha(2)M inhibits tyrosine phosphorylation of neurotrophin-3-induced trkC and its signal transduction in a dose-dependent manner in NIH3T3 cells expressing trkC (NIH3T3-trkC). In contrast to monoamine-activated alpha(2)M, normal alpha(2)M has little or no significant inhibitory effect on the phosphorylation of trkB and trkC. In addition, the retinoic acid-promoted tyrosine phosphorylation of phospholipase C-gamma 1, ERK-1, and/or ERK-2 in SH-SY5Y cells was unaffected by monoamine-activated alpha(2)M; this suggests that the inhibitory effect of activated alpha(2)M on the neurotrophin-stimulated phosphorylation of intracellular signalling proteins may be specific. Taken together, the data indicate that activated alpha(2)M is a pan-trk inhibitor, which by virtue of its binding to trk receptors may block trk-mediated signal transduction in dopaminergic neurons and lead to reduction of dopamine concentration in corpus striatum.
Identifier
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n/a
Format
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Journal Article or Conference Abstract Publication
1998
alpha(2)-macroglobulin
Alzheimer's disease
Biochemistry & Molecular Biology
cerebrospinal-fluid
dopaminergic-neurons
Hu Y Q
Journal Article or Conference Abstract Publication
Journal of neurochemistry
Koo P H
Mitogen-Activated Protein Kinases
nerve growth-factor
neurite outgrowth
Neurodegenerative Diseases
Neurosciences & Neurology
neurotrophic factor
neurotrophins
phospholipase C-gamma 1
rat caudate-putamen
signal-transduction
tyrosine protein-kinase
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1749-6632.1994.tb44340.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1749-6632.1994.tb44340.x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
460-464
Volume
737
Search for Full-text
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Dublin Core
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Title
A name given to the resource
Monoamine-activated Alpha(2)-macroglobulin Inhibits Neurite Outgrowth, Survival, Choline-acetyltransferase, And Dopamine Concentration Of Neurons By Blocking Neurotrophin-receptor (trk) Phosphorylation And Signal-transduction
Publisher
An entity responsible for making the resource available
Biology of Alpha2-Macroglobulin, Its Receptor, and Related Proteins
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994
Subject
The topic of the resource
alpha(2)-macroglobulin; alpha-macroglobulin; nerve growth-factor
Creator
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Koo P H; Liebl D J; Qiu W S; Hu Y Q; Dluzen D E
Identifier
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<a href="http://doi.org/10.1111/j.1749-6632.1994.tb44340.x" target="_blank" rel="noreferrer noopener">10.1111/j.1749-6632.1994.tb44340.x</a>
Format
The file format, physical medium, or dimensions of the resource
Book Chapter
1994
alpha-macroglobulin
alpha(2)-macroglobulin
Biology of Alpha2-Macroglobulin, Its Receptor, and Related Proteins
Book Chapter
Dluzen D E
Hu Y Q
Koo P H
Liebl D J
nerve growth-factor
Qiu W S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1471-4159.2000.0740081.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1471-4159.2000.0740081.x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
81-91
Issue
1
Volume
74
Search for Full-text
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Dublin Core
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Title
A name given to the resource
Rat Alpha(1)-macroglobulin Enhances Nerve Growth Factor-promoted Neurite Outgrowth, Trka Phosphorylation, And Gene Expression Of Pheochromocytoma Pc12 Cells
Publisher
An entity responsible for making the resource available
Journal of Neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-01
Subject
The topic of the resource
alpha-2-macroglobulin receptor; alpha-macroglobulins; alpha(2)-macroglobulin; Biochemistry & Molecular Biology; caudate putamen; cerebral cortical-neurons; choline-acetyltransferase; delayed-response genes; immediate-early genes; myelin-associated glycoprotein; nerve growth factor receptor; neurite-promoting factor; Neurosciences & Neurology; ngf receptor; protein; signal; signal-transduction; transduction
Creator
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Lee P G; Koo P H
Description
An account of the resource
Monoamine-activated human alpha(2)-macroglobulin (alpha(2)M) has been previously demonstrated to inhibit TrkA-, TrkB-, and TrkC-mediated signal transduction. Rat alpha(1),-macroglobulin (alpha(1)M) and alpha(2)M are structural homologues of human alpha(2)M, but rat alpha(1)M is distinctly different from rat alpha(2)M in many ways and its role in the mammalian nervous system is unknown. In this report, monoamine-activated rat alpha(1)M was demonstrated to enhance in a dose-dependent manner nerve growth factor (NGF)-promoted neurite outgrowth in pheochromocytoma PC12 cells. Monoamine-activated alpha(1)M by itself, however, was neither neurotrophic nor mitogenic to PC12 cells. To investigate further its possible mode of action, the ability of monoamine-activated alpha(1)M and normal alpha(1)M to bind and to activate the NGF receptor (TrkA) was investigated. Monoamine-activated alpha(1)M formed a more stable complex with TrkA than normal alpha(1)M, but the binding of mono-amina-activated alpha(1)M to TrkA was adversely affected by prior stimulation of TrkA with NGF. In addition, monoamine-activated alpha(1)M enhanced the NGF-promoted TrkA phosphorylation and up-regulated the expression of NGF-inducible immediate-early genes (c-jun and NGFI-A) and delayed-response genes (SCG10 and transin) in PC12 cells; normal alpha(1)M, in contrast, produced little or no effect, This study demonstrates that alpha(1)M, the constitutive form of ar-macroglobulin in the rat, possesses the ability to promote NGF-mediated differentiation in PC12 cells, possibly via its direct action on TrkA receptors and TrkA-mediated signal transduction and gene expression.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1471-4159.2000.0740081.x" target="_blank" rel="noreferrer noopener">10.1046/j.1471-4159.2000.0740081.x</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2000
alpha-2-macroglobulin receptor
alpha-macroglobulins
alpha(2)-macroglobulin
Biochemistry & Molecular Biology
caudate putamen
cerebral cortical-neurons
choline-acetyltransferase
delayed-response genes
immediate-early genes
Journal Article or Conference Abstract Publication
Journal of neurochemistry
Koo P H
Lee P G
myelin-associated glycoprotein
nerve growth factor receptor
neurite-promoting factor
Neurosciences & Neurology
ngf receptor
Protein
signal
signal-transduction
Transduction