1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
3279-3287
Issue
4
Volume
23
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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The in vitro antitumor activity of vitamins C and K-3 against ovarian carcinoma
Publisher
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Anticancer Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-07
Subject
The topic of the resource
alternative medicine use; aspects; autoschizis; cancer-chemotherapy; cell-lines; double-blind; k-3 combinations; mitomycin-c; Oncology; ovarian-cancer; phase-ii trial; pretreatment; tumor; ultrastructural; vitamin C; vitamin K-3
Creator
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Von Gruenigen V E; Jamison J M; Gilloteaux J; Lorimer H E; Summers M; Pollard R R; Gwin C A; Summers J L
Description
An account of the resource
Background: The objective was to evaluate the cytotoxic effect and mechanism of action of vitamins C (VC) and K-3 (VK3) on ovarian carcinoma. Materials and Methods: Cytotoxicity assays were performed on ovarian cancer cell lines with VC, VK3 or a VC/VK3 combination. FIC index was employed to evaluate synergism. Flow cytometry was accomplished at 90% cytotoxic doses. Light, transmission electron microscopy and DNA isolation were performed. Results: Antitumor activity was exhibited by both VC, VK3 and VC/VK3. VC/VK3 demonstrated synergistic activity. VC/VK3 may induce a G(1) block in the cell cycle. Combined vitamin treatment resulted in cells that maintain apparently intact nuclei while extruding pieces of organelle-free cytoplasm. Degradation of chromosomal DNA was observed. Conclusion: Cell death (autoschizis) displayed characteristics of both apoptosis and necrosis. The cytotoxic effects observed may enable vitamins C and K-3 to play an adjuvant role in the treatment of ovarian cancer.
Identifier
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n/a
Format
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Journal Article
2003
alternative medicine use
Anticancer research
aspects
autoschizis
cancer-chemotherapy
cell-lines
double-blind
Gilloteaux J
Gwin C A
Jamison J M
Journal Article
k-3 combinations
Lorimer H E
mitomycin-c
oncology
ovarian-cancer
phase-ii trial
Pollard R R
pretreatment
Summers J L
Summers M
Tumor
ultrastructural
vitamin C
vitamin K-3
von Gruenigen V E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ygyno.2006.01.059" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ygyno.2006.01.059</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
120-126
Issue
1
Volume
103
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Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Longitudinal assessment of quality of life and lifestyle in newly diagnosed ovarian cancer patients: The roles of surgery and chemotherapy
Publisher
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Gynecologic Oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-10
Subject
The topic of the resource
alternative medicine use; behaviors; breast-cancer; chemotherapy; complementary and alternative medicine; complementary/alternative; energy-balance; functional assessment; gynecologic; medicine; Obstetrics & Gynecology; Oncology; Oncology; ovarian-cancer; quality-of-life; receiving adjuvant chemotherapy; Surgery; trial; women
Creator
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Von Gruenigen V E; Frasure H E; Jenison E L; Hopkins M P; Gil K M
Description
An account of the resource
Objectives. To prospectively evaluate quality of life (QoL), use of complementary and alternative medicine (CAM), and diet/exercise changes in ovarian cancer patients during the first 6 months following diagnosis. Methods. Patients with newly diagnosed ovarian cancer were enrolled pre- or post-operatively and surveyed at 3 and 6 months. The Functional Assessment of Cancer Therapy (FACT-G), Medical Outcomes Survey (SF-36), and CAM/diet/exercise questionnaires were used. Independent samples t test and repeated measures ANOVA were used. Results. Forty-two patients underwent surgical debulking and staging prior to chemotherapy. Patients completing the initial surveys post-operatively had significantly lower physical FACT-G and SF-36 physical scores compared to patients completing the surveys pre-operatively. In patients completing the baseline survey pre-operatively, there was a decrease in physical scores at 3 months (after surgery and during chemotherapy). There was no change observed at 3 months relative to baseline when patients completed the baseline survey post-operatively. Increases in physical and functional well-being were seen at 6 months relative to 3 months. There were no changes in emotional or social scores over time. CAM use increased over time; main reasons were to improve QoL and relieve symptoms. Alterations in diet and exercise were not seen. Conclusions. These data highlight the need to conduct assessments before and after surgery to identify effects due to surgery and/or chemotherapy. Patients may be using CAM during chemotherapy to deal with symptoms and compensate for decreased QoL. Intervention trials should be implemented to increase QoL following surgery and during adjuvant chemotherapy. (c) 2006 Elsevier Inc. All rights reserved.
Identifier
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<a href="http://doi.org/10.1016/j.ygyno.2006.01.059" target="_blank" rel="noreferrer noopener">10.1016/j.ygyno.2006.01.059</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2006
alternative medicine use
behaviors
breast-cancer
Chemotherapy
complementary and alternative medicine
complementary/alternative
energy-balance
Frasure H E
Functional Assessment
Gil K M
gynecologic
Gynecologic oncology
Hopkins M P
Jenison E L
Journal Article
Medicine
Obstetrics & Gynecology
oncology
ovarian-cancer
quality-of-life
receiving adjuvant chemotherapy
Surgery
trial
von Gruenigen V E
Women