1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.00417.2000" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00417.2000</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
L642-L649
Issue
4
Volume
282
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Alveolar epithelial ion and fluid transport - Ca2(+)-dependent stimulation of alveolar fluid clearance in near-term fetal guinea pigs
Publisher
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American Journal of Physiology-Lung Cellular and Molecular Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-04
Subject
The topic of the resource
adrenaline; agonist; amiloride; birth; blood-flow; cation; channel; distal lung epithelium; expression; lamb; liquid; oxytocin-induced preterm labor; Physiology; protein clearance; Respiratory System; sodium transport; surfactant secretion
Creator
An entity primarily responsible for making the resource
Norlin A; Folkesson H G
Description
An account of the resource
We investigated the importance of changes in intracellular Ca2+ concentration ([Ca2+](i)) for amiloride-sensitive alveolar fluid clearance (AFC) in late-gestational guinea pigs. Fetal guinea pigs of 61, 68, and 69 days (term) gestation were investigated under normal conditions and after oxytocin-induced preterm labor. AFC or alveolar fluid secretion was measured using an impermeable tracer technique. At 61 days gestation there was net secretion of fluid into the lungs, and at birth the lungs cleared 49 +/- 7% of the instilled fluid volume over 1 h. Induction of preterm labor with oxytocin induced AFC at 61 days gestation. When present, AFC was inhibited or reversed to net fluid secretion by amiloride (10(-3) M). Inhibition of membrane Ca2+ channels by verapamil (10(-4) M) or depletion of intracellular Ca2+ by thapsigargin (10(-5) M) reduced AFC when net AFC was evident. Amiloride lacked an inhibitory effect on AFC when instilled with verapamil or thapsigargin. The results indicate that AFC via amiloride-sensitive pathways develops during late gestation, and that inducing preterm labor precociously may activate such pathways. Our results suggest that Ca2+ may act as a second messenger in mediating catecholamine-stimulated AFC.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.00417.2000" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00417.2000</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2002
adrenaline
agonist
American Journal of Physiology-Lung Cellular and Molecular Physiology
amiloride
birth
blood-flow
cation
channel
distal lung epithelium
expression
Folkesson H G
Journal Article
lamb
Liquid
Norlin A
oxytocin-induced preterm labor
Physiology
protein clearance
Respiratory System
sodium transport
surfactant secretion
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.00445.2010" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00445.2010</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
L804-L811
Issue
5
Volume
301
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Phosphatidylinositol 4,5-bisphosphate Stimulates Alveolar Epithelial Fluid Clearance In Male And Female Adult Rats
Publisher
An entity responsible for making the resource available
American Journal of Physiology-Lung Cellular and Molecular Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-11
Subject
The topic of the resource
5-bisphosphate; absorption; acute lung injury; alpha; alveolar epithelial barrier; amiloride; beta; beta-adrenoceptor agonists; catecholamines; female advantage; in alveolar fluid clearance; lung liquid clearance; na+ channel enac; permeability; phosphatidylinositol-4; Physiology; pulmonary edema; Respiratory System; rna interference; sodium transport; sodium-channel; transport; water
Creator
An entity primarily responsible for making the resource
Kooijman E E; Kuzenko S R; Gong D H; Best M D; Folkesson H G
Description
An account of the resource
Kooijman EE, Kuzenko SR, Gong D, Best MD, Folkesson HG. Phosphatidylinositol 4,5-bisphosphate stimulates alveolar epithelial fluid clearance in male and female adult rats. Am J Physiol Lung Cell Mol Physiol 301: L804-L811, 2011. First published August 26, 2011; doi:10.1152/ajplung.00445.2010.-Cell membrane phospholipids, like phosphatidylinositol 4,5-bisphosphate [PI(4,5)P-2], can regulate epithelial Na channel (ENaC) activity. Gender differences in lung ENaC expression have also been demonstrated. However, the effects in vivo on alveolar fluid clearance are uncertain. Thus PI(4,5)P-2 effects on alveolar fluid clearance were studied in male and female rats. An isosmolar 5% albumin solution was intrapulmonary instilled; alveolar fluid clearance was studied for 1 h. Female rats had a 37 +/- 19% higher baseline alveolar fluid clearance than male rats. Bilateral ovariectomy attenuated this gender difference. Compared with controls, PI(4,5)P-2 instillation (300 mu M) increased alveolar fluid clearance by similar to 93% in both genders. Amiloride or the specific alpha ENaC small-interfering RNA inhibited baseline and PI(4,5)P-2-stimulated alveolar fluid clearance in both genders, indicating a dependence on amiloride-sensitive pathways. The fraction of amiloride inhibition was greater in PI(4,5)P-2-instilled rats (male: 64 +/- 10%; female: 70 +/- 11%) than in controls (male: 30 +/- 6%; female: 44 +/- 8%). PI(4,5)P-2 instillation lacked additional alveolar fluid clearance stimulation above that of terbutaline, nor did propranolol inhibit alveolar fluid clearance after PI(4,5)P-2 instillation, indicating that PI(4,5)P-2 stimulation was not secondary to endogenous beta-adrenoceptor activation. PI(4,5)P-2 amine instillation resulted in an intermediate alveolar fluid clearance stimulation, suggesting that, to reach maximal alveolar fluid clearance stimulation, PI(4,5)P-2 must reside in cell membranes. In summary, PI(4,5)P-2 instillation upregulated in vivo alveolar fluid clearance similar to short-term beta-adrenoceptor upregulation of alveolar fluid clearance. PI(4,5)P-2 stimulation was mediated partly by increased amiloride-sensitive Na transport. There exist important gender-related effects suggesting a female advantage that may have clinical implications for resolution of acute lung injury.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.00445.2010" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00445.2010</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2011
5-bisphosphate
Absorption
acute lung injury
alpha
alveolar epithelial barrier
American Journal of Physiology-Lung Cellular and Molecular Physiology
amiloride
Best M D
beta
beta-adrenoceptor agonists
catecholamines
female advantage
Folkesson H G
Gong D H
in alveolar fluid clearance
Journal Article or Conference Abstract Publication
Kooijman E E
Kuzenko S R
lung liquid clearance
na+ channel enac
Permeability
phosphatidylinositol-4
Physiology
pulmonary edema
Respiratory System
RNA Interference
sodium transport
sodium-channel
transport
Water