Metabolic labeling with heavy water followed by LC-MS is a high throughput approach to study proteostasis in vivo. Advances in mass spectrometry and sample processing have allowed consistent detection of thousands of proteins at multiple time points.…
Age-related hearing loss may result, in part, from declining levels of gamma-amino butyric acid (GABA) in the aging inferior colliculus (IC). An upregulation of the GABA(A)R gamma(1) subunit, which has been shown to increase sensitivity to GABA,…
