1
40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0142-9612(03)00172-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0142-9612(03)00172-8</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
3483-3491
Issue
20
Volume
24
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Characterization And Performance Of Membranes Designed For Macroencapsulation/implantation Of Pancreatic Islet Cells
Publisher
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Biomaterials
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-09
Subject
The topic of the resource
amphiphilic networks; amphiphilic polymer membranes; Engineering; glucose challenge; macroencapsulation of pancreatic islets; macroencapsulatory membranes; Materials Science; oxygen permeability; polyisobutylene; rat; stars
Creator
An entity primarily responsible for making the resource
Isayeva I S; Kasibhatla B T; Rosenthal K S; Kennedy J P
Description
An account of the resource
Amphiphilic polymer membranes were synthesized for macroencapsulation of cells and characterized by select chemical and biological techniques. The membranes were prepared by crosslinking hydrophilic poly(N,N-dimethyl acrylamide) (PDMAAm) main chains with hydrophobic di-, tri-, and octa-methacrylate telechelic polyisobutylene (PIB) stars. The hydrophilic/hydrophobic composition and the molecular weights between crosslink sites (both M-c,M-hydrophilic and M-c,M-hydrophobic) were controlled by synthesis conditions. Small tubular membranes were made by in situ rotational copolymerization/crosslinking and filled with pancreatic rat islets. The water-swelling behavior, mechanical properties, and oxygen and insulin diffusion were studied. Macroencapsulatory performance of these membranes was investigated in vitro by macroencapsulation of pancreatic rat islets within tubular membranes for up to 1.5 months, and studying the insulin secreting ability of encapsulated islets in culture. The membranes are robust and maintain their integrity for the period of encapsulation. They allow oxygen and insulin diffusion. Macroencapsulated islets maintained their viability and insulin secretion over an extended period (i.e., 45 days). (C) 2003 Elsevier Science Ltd. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0142-9612(03)00172-8" target="_blank" rel="noreferrer noopener">10.1016/s0142-9612(03)00172-8</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2003
amphiphilic networks
amphiphilic polymer membranes
Biomaterials
Engineering
glucose challenge
Isayeva I S
Journal Article or Conference Abstract Publication
Kasibhatla B T
Kennedy J P
macroencapsulation of pancreatic islets
macroencapsulatory membranes
Materials Science
oxygen permeability
polyisobutylene
rat
Rosenthal K S
stars
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1163/1568555042474112" target="_blank" rel="noreferrer noopener">http://doi.org/10.1163/1568555042474112</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
485-494
Issue
6
Volume
7
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Two Generations Of Synthetic Membranes For Biological/medical Applications
Publisher
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Designed Monomers and Polymers
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004
Subject
The topic of the resource
amphiphilic membranes; amphiphilic networks; biocompatibility; diffusion; domains; Glucose; immunoisolation; insulin diffusion; isobutylene; living carbocationic polymerization; membranes; polyisobutylene; Polymer Science; polymers; selective permeability; tricomponent
Creator
An entity primarily responsible for making the resource
Kennedy J P; Rosenthal K S; Kashibhatla B
Description
An account of the resource
Two generations of amphiphilic membranes synthesized in our laboratories for biologicaUniedical applications are highlighted. Recent results obtained with representative 2nd generation membranes designed specifically for immunoencapsulation of pancreatic islets and cells, are Summarized. The latter tri-component membranes comprise well-defined hydrophilic poly(ethylene glycol) and hydrophobic/oxyphilic polydimethylsiloxane segments crosslinked by oxyphilic polycyclosiloxane domains, which also provide reinforcement. Select membranes are demonstrated to allow the diffusion of glucose and insulin but prevent the permeation of immunoglobulin G. These membranes remain permeable despite long incubation in IgG solution.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1163/1568555042474112" target="_blank" rel="noreferrer noopener">10.1163/1568555042474112</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2004
amphiphilic membranes
amphiphilic networks
Biocompatibility
Designed Monomers and Polymers
diffusion
domains
GLUCOSE
immunoisolation
insulin diffusion
isobutylene
Journal Article or Conference Abstract Publication
Kashibhatla B
Kennedy J P
living carbocationic polymerization
membranes
polyisobutylene
Polymer Science
Polymers
Rosenthal K S
selective permeability
tricomponent