1
40
18
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s10456-021-09775-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s10456-021-09775-9</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
ISSN
1573-7209 0969-6970
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1007/s10456-021-09775-9" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1007/s10456-021-09775-9</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
March 2021 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Integrative Medical Sciences
NEOMED Postdoc Publications
NEOMED Student Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity.
Publisher
An entity responsible for making the resource available
Angiogenesis
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-03-03
Subject
The topic of the resource
Endothelial cell; Metastasis; Transient receptor potential vanilloid 4; Tumor angiogenesis; Vascular endothelial growth factor receptor 2
Creator
An entity primarily responsible for making the resource
Kanugula AK; Adapala RK; Jamaiyar A; Lenkey N; Guarino BD; Liedtke W; Yin L; Paruchuri S; Thodeti CK
Description
An account of the resource
Transient receptor potential vanilloid 4 (TRPV4) is a ubiquitously expressed polymodally activated ion channel. TRPV4 has been implicated in tumor progression; however, the cell-specific role of TRPV4 in tumor growth, angiogenesis, and metastasis is unknown. Here, we generated endothelial-specific TRPV4 knockout (TRPV4(ECKO)) mice by crossing TRPV4(lox/lox) mice with Tie2-Cre mice. Tumor growth and metastasis were significantly increased in a syngeneic Lewis lung carcinoma tumor model of TRPV4(ECKO) mice compared to TRPV4(l)(ox/lox) mice. Multiphoton microscopy, dextran leakage, and immunohistochemical analysis revealed increased tumor angiogenesis and metastasis that were correlated with aberrant leaky vessels (increased width and reduced pericyte and VE-cadherin coverage). Mechanistically, increases in VEGFR2, p-ERK, and MMP-9 expression and DQ gelatinase activity were observed in the TRPV4(ECKO) mouse tumors. Our results demonstrated that endothelial TRPV4 is a critical modulator of vascular integrity and tumor angiogenesis and that deletion of TRPV4 promotes tumor angiogenesis, growth, and metastasis.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s10456-021-09775-9" target="_blank" rel="noreferrer noopener">10.1007/s10456-021-09775-9</a>
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2021
Adapala RK
angiogenesis
Department of Integrative Medical Sciences
endothelial cell
Guarino BD
Jamaiyar A
journalArticle
Kanugula AK
Lenkey N
Liedtke W
March 2021 List
Metastasis
NEOMED College of Medicine
NEOMED Postdoc Publications
NEOMED Student Publications
Paruchuri S
Thodeti CK
Transient receptor potential vanilloid 4
tumor angiogenesis
Vascular endothelial growth factor receptor 2
Yin L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/" target="_blank" rel="noreferrer noopener">http://doi.org/</a>
Pages
E274-E275
Issue
12
Volume
127
ISSN
0009-7330
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: </a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
January 2021 List
NEOMED College
NEOMED College of Medicine
NEOMED College of Graduate Studies
NEOMED Department
Department of Integrative Medical Sciences
NEOMED Student Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Endothelial Trpv4 contributes to pressure overload-induced pathological hypertrophy via modulation of coronary angiogenesis
Publisher
An entity responsible for making the resource available
Circulation Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-12-04
Subject
The topic of the resource
Angiogenesis; Fibrosis; Ion channels; Cardiac hypertrophy;
Creator
An entity primarily responsible for making the resource
Adapala RK; Kanugula AK; Ohanyan VA; Paruchuri SM; Chilian WM; Thodeti CK
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/" target="_blank" rel="noreferrer noopener"></a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Adapala RK
angiogenesis
Cardiac hypertrophy
Chilian WM
Circulation research
Department of Integrative Medical Sciences
Fibrosis
Ion Channels
January 2021 List
journalArticle
Kanugula AK
NEOMED College of Graduate Studies
NEOMED College of Medicine
NEOMED Student Publications
Ohanyan VA
Paruchuri SM
Thodeti CK
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.exer.2020.108257" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.exer.2020.108257</a>
Pages
108257
Volume
201
ISSN
1096-0007
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1016/j.exer.2020.108257" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/j.exer.2020.108257</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
September 2020 List
NEOMED College
NEOMED College of Medicine Student
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
Department of Integrative Medical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The role of TRPV4 channels in ocular function and pathologies.
Publisher
An entity responsible for making the resource available
Experimental Eye Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-09-29
Subject
The topic of the resource
Glaucoma; TRPV4; Angiogenesis; Retina; Calcium channel; Cornea; Diabetic retinopathy; Lens; Osmolarity
Creator
An entity primarily responsible for making the resource
Guarino BD;Paruchuri S;Thodeti CK
Description
An account of the resource
Transient potential receptor vanilloid 4 (TRPV4) is an ion channel responsible for sensing osmotic and mechanical signals, which in turn regulates calcium signaling across cell membranes. TRPV4 is widely expressed throughout the body, and plays an important role in normal physiological function, as well as different pathologies, however, its role in the eye is not well known. In the eye, TRPV4 is expressed in various tissues, such as the retina, corneal epithelium, ciliary body, and the lens. In this review, we provide an overview on TRPV4 structure, activation, mutations, and summarize the current knowledge of TRPV4 function and signaling mechanisms in various locations throughout the eye, as well as its role in ocular diseases, such as glaucoma and diabetic retinopathy. Based on the available data, we highlight the therapeutic potential of TRPV4 as well as the shortcomings of current research. Finally, we provide future perspectives on the implications of targeting TRPV4 to treat various ocular pathologies. (Copyright © 2020 Elsevier Ltd. All rights reserved.)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.exer.2020.108257" target="_blank" rel="noreferrer noopener">10.1016/j.exer.2020.108257</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
angiogenesis
calcium channel
Cornea
Department of Integrative Medical Sciences
diabetic retinopathy
Experimental eye research
Glaucoma
Guarino BD
journalArticle
Lens
NEOMED College of Medicine
NEOMED College of Medicine Student
NEOMED Student Publications
Osmolarity
Paruchuri S
retina
September 2020 List
Thodeti CK
TRPV4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/lsm.22296" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/lsm.22296</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
679-688
Issue
9
Volume
46
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Topical Rapamycin Systematically Suppresses The Early Stages Of Pulsed Dye Laser-induced Angiogenesis Pathways
Publisher
An entity responsible for making the resource available
Lasers in Surgery and Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-11
Subject
The topic of the resource
angiogenesis; birthmarks; Dermatology; growth-factor; hypoxia; mechanisms; P70S6K; port wine stain; port wine stain; Pulsed dye laser; rapamycin; resistance; Surgery; vessels
Creator
An entity primarily responsible for making the resource
Gao L; Phan S; Nadora D M; Chernova M; Sun V; Preciado S M O; Ballew B; Jia Z Y; Jia W C; Wang G; Mihm M C; Nelson J S; Tan W B
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/lsm.22296" target="_blank" rel="noreferrer noopener">10.1002/lsm.22296</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2014
angiogenesis
Ballew B
birthmarks
Chernova M
Dermatology
Gao L
growth-factor
hypoxia
Jia W C
Jia Z Y
Lasers in surgery and medicine
mechanisms
Mihm M C
Nadora D M
Nelson J S
P70S6K
Phan S
port wine stain
Preciado S M O
Pulsed dye laser
rapamycin
resistance
Sun V
Surgery
Tan W B
vessels
Wang G
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/ncb2580" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/ncb2580</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1046-+
Issue
10
Volume
14
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Stimulus-dependent Phosphorylation Of Profilin-1 In Angiogenesis
Publisher
An entity responsible for making the resource available
Nature Cell Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-10
Subject
The topic of the resource
actin polymerization; angiogenesis; cancer; Cell Biology; chemotaxis; endothelial-cell migration; growth-factor; motility; pathway; tumor; tyrosine kinases; vegf
Creator
An entity primarily responsible for making the resource
Fan Y; Arif A; Gong Y Q; Jia J; Eswarappa S M; Willard B; Horowitz A; Graham L M; Penn M S; Fox P L
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/ncb2580" target="_blank" rel="noreferrer noopener">10.1038/ncb2580</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
actin polymerization
angiogenesis
Arif A
Cancer
Cell Biology
chemotaxis
endothelial-cell migration
Eswarappa S M
Fan Y
Fox P L
Gong Y Q
Graham L M
growth-factor
Horowitz A
Jia J
motility
Nature Cell Biology
pathway
Penn M S
Tumor
tyrosine kinases
vegf
Willard B
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
85-88
Issue
2
Volume
10
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Role Of Urokinase Pais In The Control Of Cancer Invasion And Metastasis
Publisher
An entity responsible for making the resource available
Drug News & Perspectives
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-03
Subject
The topic of the resource
adenocarcinomas; angiogenesis; cells; degradation; inhibition; in-vitro; migration; Pharmacology & Pharmacy; plasminogen-activator; receptor; tumor-metastasis
Creator
An entity primarily responsible for making the resource
Evans D M; Sloan-Stakleff K
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1997
adenocarcinomas
angiogenesis
Cells
degradation
Drug News & Perspectives
Evans D M
in-vitro
inhibition
migration
Pharmacology & Pharmacy
plasminogen-activator
Receptor
Sloan-Stakleff K
tumor-metastasis
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
460-464
Issue
5
Volume
66
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Suppression Of The Invasive Capacity Of Human Breast Cancer Cells By Inhibition Of Urokinase Plasminogen Activator Via Amiloride And B428
Publisher
An entity responsible for making the resource available
American Surgeon
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-05
Subject
The topic of the resource
angiogenesis; carcinoma; integrins; migration; prevention; prognostic marker; proliferation; pulmonary metastases; receptor; Surgery; tumor-cells
Creator
An entity primarily responsible for making the resource
Evans D M; Sloan-Stakleff K
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2000
American Surgeon
angiogenesis
Carcinoma
Evans D M
integrins
migration
Prevention
prognostic marker
proliferation
pulmonary metastases
Receptor
Sloan-Stakleff K
Surgery
tumor-cells
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1161/01.RES.0000338258.90706.2c" target="_blank" rel="noreferrer noopener">http://doi.org/10.1161/01.RES.0000338258.90706.2c</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
905-906
Issue
9
Volume
103
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Vascular Endothelial Growth Factor and the Collateral Circulation The Story Continues
Publisher
An entity responsible for making the resource available
Circulation Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-10
Subject
The topic of the resource
angiogenesis; arteriogenesis; receptors; cells; Cardiovascular System & Cardiology; expression; Hematology; skeletal-muscle; permeability factor; vasculogenesis; vasculotropin; vegf family-members
Creator
An entity primarily responsible for making the resource
Chilian W M; Pung Y F
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1161/01.RES.0000338258.90706.2c" target="_blank" rel="noreferrer noopener">10.1161/01.RES.0000338258.90706.2c</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2008
angiogenesis
Arteriogenesis
Cardiovascular System & Cardiology
Cells
Chilian W M
Circulation research
expression
Hematology
Journal Article or Conference Abstract Publication
permeability factor
Pung Y F
Receptors
skeletal-muscle
vasculogenesis
vasculotropin
vegf family-members
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
E125-E125
Issue
12
Volume
117
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mechanosensitive Ion Channel TRPV4 Negatively Regulates Angiogenesis Via Modulation Of Rho/Rho Kinase Pathway
Publisher
An entity responsible for making the resource available
Circulation Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-12
Subject
The topic of the resource
TRPV4; angiogenesis; Cardiovascular System & Cardiology; Hematology; endothelial; mechanosensitive; Rho
Creator
An entity primarily responsible for making the resource
Cappelli H C; Thoppil R; Adapala R K; Meszaros J G; Paruchuri S; Thodeti C
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2015
Adapala R K
angiogenesis
Cappelli H C
Cardiovascular System & Cardiology
Circulation research
Endothelial
Hematology
Journal Article or Conference Abstract Publication
mechanosensitive
Meszaros J G
Paruchuri S
Rho
Thodeti C
Thoppil R
TRPV4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1161/atvbaha.109.186189" target="_blank" rel="noreferrer noopener">http://doi.org/10.1161/atvbaha.109.186189</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
802-U56
Issue
6
Volume
29
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Amplification of Coronary Arteriogenic Capacity of Multipotent Stromal Cells by Epidermal Growth Factor
Publisher
An entity responsible for making the resource available
Arteriosclerosis Thrombosis and Vascular Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-06
Subject
The topic of the resource
coronary circulation; angiogenesis; collateral circulation; Cardiovascular System & Cardiology; Myocardial infarction; expression; binding; Hematology; mesenchymal stem-cells; smooth-muscle-cells; rat model; endothelial-cells; collateral growth; improve heart function
Creator
An entity primarily responsible for making the resource
Belmadani S; Matrougui K; Kolz C; Pung Y F; Palen D; Prockop D J; Chilian W M
Description
An account of the resource
Objective-We determined whether increasing adherence of multipotent stromal cells (MSCs) would amplify their effects on coronary collateral growth (CCG). Methods and Results-Adhesion was established in cultured coronary endothelials cells (CECs) or MSCs treated with epidermal growth factor (EGF). EGF increased MSCs adhesion to CECs, and increased intercellular adhesion molecule (ICAM-1) or vascular cell adhesion molecule (VCAM-1) expression. Increased adherence was blocked by EGF receptor antagonism or antibodies to the adhesion molecules. To determine whether adherent MSCs, treated with EGF, would augment CCG, repetitive episodes of myocardial ischemia (RI) were introduced and CCG was measured from the ratio of collateral-dependent (CZ) and normal zone (NZ) flows. CZ/NZ was increased by MSCs without treatment versus RI-control and was further increased by EGF-treated MSCs. EGF-treated MSCs significantly improved myocardial function versus RI or RI + MSCs demonstrating that the increase in collateral flow was functionally significant. Engraftment of MSCs into myocardium was also increased by EGF treatment. Conclusions-These results reveal the importance of EGF in MSCs adhesion to endothelium and suggest that MSCs may be effective therapies for the stimulation of coronary collateral growth when interventions are used to increase their adhesion and homing (in vitro EGF treatment) to the jeopardized myocardium. (Arterioscler Thromb Vasc Biol. 2009; 29: 802-808.)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1161/atvbaha.109.186189" target="_blank" rel="noreferrer noopener">10.1161/atvbaha.109.186189</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2009
angiogenesis
Arteriosclerosis Thrombosis and Vascular Biology
Belmadani S
Binding
Cardiovascular System & Cardiology
Chilian W M
Collateral Circulation
collateral growth
Coronary Circulation
endothelial-cells
expression
Hematology
improve heart function
Journal Article or Conference Abstract Publication
Kolz C
Matrougui K
mesenchymal stem-cells
myocardial infarction
Palen D
Prockop D J
Pung Y F
rat model
smooth-muscle-cells
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2-2
Issue
21
Volume
122
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Rotenone-Induced Mitochondrial Oxidative Stress Corrupts Tube Formations in Human Coronary Artery Endothelial Cells by Inhibiting mTOR Signaling Pathway
Publisher
An entity responsible for making the resource available
Circulation
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-11
Subject
The topic of the resource
Angiogenesis; Cardiovascular System & Cardiology; Mitochondria; oxidative stress
Creator
An entity primarily responsible for making the resource
Pung Y F; Kolz C; Chilian W M
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2010
angiogenesis
Cardiovascular System & Cardiology
Chilian W M
Circulation
Journal Article
Kolz C
Mitochondria
Oxidative Stress
Pung Y F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/nprot.2009.190" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/nprot.2009.190</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1749-1758
Issue
12
Volume
4
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Measuring bone blood supply in mice using fluorescent microspheres
Publisher
An entity responsible for making the resource available
Nature Protocols
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009
Subject
The topic of the resource
Angiogenesis; Biochemistry & Molecular Biology; flow measurement; hindlimb ischemia; mouse models; perfusion; rabbits; rats
Creator
An entity primarily responsible for making the resource
Serrat M A
Description
An account of the resource
Fluorescent microspheres are commonly used to assess bone blood supply in large animals, but the technique is not widely used in smaller mammals, as traditional methods such as reference blood sampling, ventilation and catheterization are not easily applied. This protocol describes a viable alternative for measuring bone and organ perfusion in mice using modified fluorescent microsphere techniques. Microspheres are injected directly into the left heart and a reference tissue is used to calculate relative bone and organ blood supply. On the basis of a sample of 15 mice with 5 tissues each, the entire protocol takes 140.5 h to complete from animal preparation through statistical analysis. This timing includes 72 h of mandated pauses for bone decalcification and digestion, as well as 48 h for data analysis. Exclusive of pauses or additional analyses that could increase the time required, this protocol takes 20.5 h bench time to complete.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/nprot.2009.190" target="_blank" rel="noreferrer noopener">10.1038/nprot.2009.190</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2009
angiogenesis
Biochemistry & Molecular Biology
flow measurement
hindlimb ischemia
Journal Article
mouse models
Nature Protocols
Perfusion
Rabbits
Rats
Serrat M A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.00247.2019" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.00247.2019</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Exosomes derived from Induced Vascular Progenitor Cells Promote Angiogenesis in vitro and in an in vivo Rat Hindlimb Ischemia Model
Publisher
An entity responsible for making the resource available
American Journal of Physiology. Heart and Circulatory Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-08
Subject
The topic of the resource
angiogenesis; endothelial cell; exosome; microRNA; progenitor cell
Creator
An entity primarily responsible for making the resource
Johnson Takerra K; Zhao Lina; Zhu Dihan; Wang Yang; Xiao Yan; Oguljahan Babayewa; Zhao Xueying; Kirlin Ward G; Yin Liya; Chilian William M; Liu Dong
Description
An account of the resource
Induced vascular progenitor cells (iVPCs) were created as an ideal cell type for regenerative medicine and have been reported to positively promote collateral blood flow and improve cardiac function in a rat model of myocardial ischemia. Exosomes have emerged as a novel biomedicine that mimics the function of the donor cells. We investigated the angiogenic activity of exosomes from induced vascular progenitor cells (iVPC-Exo) as a cell-free therapeutic approach for ischemia. Exosomes from iVPCs and rat aortic endothelial cells (RAECs) were isolated using a combination of ultrafiltration and size-exclusion chromatography. Nanoparticle tracking analysis revealed that exosome isolates fell within the exosomal diameter (<150 nm). These exosomes contained known markers Alix and TSG101, and their morphology was validated using transmission electron microscopy. Compared to RAECs, iVPCs significantly increased the secretion of exosomes. Cardiac microvascular endothelial cells and aortic ring explants were pretreated with RAEC-Exo or iVPC-Exo, and basal medium was used as a control. iVPC-Exo exerted an in vitro angiogenic effect on the proliferation, tube formation, and migration of endothelial cells and stimulated microvessel sprouting in an ex vivo aortic ring assay. Additionally, iVPC-Exo increased blood perfusion in a hindlimb ischemia model. Proangiogenic proteins (pentraxin-3 and insulin-like growth factor-binding protein-3) and microRNAs (-143-3p, -291b, and -20b-5p) were found to be enriched in iVPC-Exo, which may mediate iVPC-Exo induced vascular growth. Our findings demonstrate that treatment with iVPC-Exo promotes angiogenesis in vitro, ex vivo, and in vivo. Collectively, these findings indicate a novel cell-free approach for therapeutic angiogenesis.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.00247.2019" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.00247.2019</a>
2019
American journal of physiology. Heart and circulatory physiology
angiogenesis
Chilian William M
Department of Integrative Medical Sciences
endothelial cell
exosome
Johnson Takerra K
Kirlin Ward G
Liu Dong
MicroRNA
NEOMED College of Medicine
Oguljahan Babayewa
progenitor cell
September 2019 Update
Wang Yang
Xiao Yan
Yin Liya
Zhao Lina
Zhao Xueying
Zhu Dihan
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.4330/wjc.v2.i12.421" target="_blank" rel="noreferrer noopener">http://doi.org/10.4330/wjc.v2.i12.421</a>
Pages
421–427
Issue
12
Volume
2
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Corruption of coronary collateral growth in metabolic syndrome: Role of oxidative stress.
Publisher
An entity responsible for making the resource available
World journal of cardiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-12
Subject
The topic of the resource
Angiogenesis; Mitochondria; Arteriogenesis; Redox-dependent signaling
Creator
An entity primarily responsible for making the resource
Pung Yuh Fen; Chilian William M
Description
An account of the resource
The myocardium adapts to ischemic insults in a variety of ways. One adaptation is the phenomenon of acute preconditioning, which can greatly ameliorate ischemic damage. However, this effect wanes within a few hours and does not confer chronic protection. A more chronic adaptation is the so-called second window of preconditioning, which enables protection for a few days. The most potent adaptation invoked by the myocardium to minimize the effects of ischemia is the growth of blood vessels in the heart, angiogenesis and arteriogenesis (collateral growth), which prevent the development of ischemia by enabling flow to a jeopardized region of the heart. This brief review examines the mechanisms underlying angiogenesis and arteriogenesis in the heart. The concept of a redox window, which is an optimal redox state for vascular growth, is discussed along with signaling mechanisms invoked by reactive oxygen species that are stimulated during ischemia-reperfusion. Finally, the review discusses of some of the pathologies, especially the metabolic syndrome, that negatively affect collateral growth through the corruption of redox signaling processes.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.4330/wjc.v2.i12.421" target="_blank" rel="noreferrer noopener">10.4330/wjc.v2.i12.421</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
angiogenesis
Arteriogenesis
Chilian William M
Department of Integrative Medical Sciences
Mitochondria
NEOMED College of Medicine
Pung Yuh Fen
Redox-dependent signaling
World journal of cardiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1161/CIRCRESAHA.115.306590" target="_blank" rel="noreferrer noopener">http://doi.org/10.1161/CIRCRESAHA.115.306590</a>
Pages
1729–1731
Issue
11
Volume
116
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A bouquet for a broken heart: can flowers repair a damaged heart?
Publisher
An entity responsible for making the resource available
Circulation research
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-05
Subject
The topic of the resource
angiogenesis; Animals; coronary vessels; Coronary Vessels/*physiopathology; Editorials; endocardium; Endocardium/*physiopathology; endothelial cells; Endothelium; myocardial infarction; Myocardial Infarction/*physiopathology; Vascular/*physiopathology
Creator
An entity primarily responsible for making the resource
Thodeti Charles K
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1161/CIRCRESAHA.115.306590" target="_blank" rel="noreferrer noopener">10.1161/CIRCRESAHA.115.306590</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
angiogenesis
Animals
Circulation research
Coronary Vessels
Coronary Vessels/*physiopathology
Department of Integrative Medical Sciences
Editorials
endocardium
Endocardium/*physiopathology
endothelial cells
Endothelium
myocardial infarction
Myocardial Infarction/*physiopathology
NEOMED College of Medicine
Thodeti Charles K
Vascular/*physiopathology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.00077.2013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.00077.2013</a>
Pages
H1275–1280
Issue
9
Volume
305
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The role of mitochondrial bioenergetics and reactive oxygen species in coronary collateral growth.
Publisher
An entity responsible for making the resource available
American journal of physiology. Heart and circulatory physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-11
Subject
The topic of the resource
*Collateral Circulation; *Coronary Circulation; *Energy Metabolism; *Neovascularization; angiogenesis; Animals; arteriogenesis; Coronary Vessels/metabolism; Humans; mitochondria; Mitochondria; Mitochondrial Proteins/metabolism; Muscle; Muscle/*metabolism; Myocytes; Oxidative Stress; Phenotype; Physiologic; Reactive Oxygen Species/*metabolism; redox-dependent signaling; Signal Transduction; Smooth; Smooth Muscle/*metabolism; Vascular/*metabolism
Creator
An entity primarily responsible for making the resource
Pung Yuh Fen; Sam Wai Johnn; Hardwick James P; Yin Liya; Ohanyan Vahagn; Logan Suzanna; Di Vincenzo Lola; Chilian William M
Description
An account of the resource
Coronary collateral growth is a process involving coordination between growth factors expressed in response to ischemia and mechanical forces. Underlying this response is proliferation of vascular smooth muscle and endothelial cells, resulting in an enlargement in the caliber of arterial-arterial anastomoses, i.e., a collateral vessel, sometimes as much as an order of magnitude. An integral element of this cell proliferation is the process known as phenotypic switching in which cells of a particular phenotype, e.g., contractile vascular smooth muscle, must change their phenotype to proliferate. Phenotypic switching requires that protein synthesis occurs and different kinase signaling pathways become activated, necessitating energy to make the switch. Moreover, kinases, using ATP to phosphorylate their targets, have an energy requirement themselves. Mitochondria play a key role in the energy production that enables phenotypic switching, but under conditions where mitochondrial energy production is constrained, e.g., mitochondrial oxidative stress, this switch is impaired. In addition, we discuss the potential importance of uncoupling proteins as modulators of mitochondrial reactive oxygen species production and bioenergetics, as well as the role of AMP kinase as an energy sensor upstream of mammalian target of rapamycin, the master regulator of protein synthesis.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.00077.2013" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.00077.2013</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Collateral Circulation
*Coronary Circulation
*Energy Metabolism
*Neovascularization
2013
American journal of physiology. Heart and circulatory physiology
angiogenesis
Animals
Arteriogenesis
Chilian William M
Coronary Vessels/metabolism
Department of Integrative Medical Sciences
Di Vincenzo Lola
Hardwick James P
Humans
Logan Suzanna
Mitochondria
Mitochondrial Proteins/metabolism
Muscle
Muscle/*metabolism
Myocytes
NEOMED College of Medicine
Ohanyan Vahagn
Oxidative Stress
Phenotype
Physiologic
Pung Yuh Fen
Reactive Oxygen Species/*metabolism
Redox-dependent signaling
Sam Wai Johnn
Signal Transduction
Smooth
Smooth Muscle/*metabolism
Vascular/*metabolism
Yin Liya
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1096/fj.201800509R" target="_blank" rel="noreferrer noopener">http://doi.org/10.1096/fj.201800509R</a>
Pages
195–203
Issue
1
Volume
33
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Novel noncanonical regulation of soluble VEGF/VEGFR2 signaling by mechanosensitive ion channel TRPV4.
Publisher
An entity responsible for making the resource available
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-01
Subject
The topic of the resource
angiogenesis; endothelial cell; phosphorylation
Creator
An entity primarily responsible for making the resource
Kanugula Anantha K; Adapala Ravi K; Midha Priya; Cappelli Holly C; Meszaros J Gary; Paruchuri Sailaja; Chilian William M; Thodeti Charles K
Description
An account of the resource
VEGF signaling via VEGF receptor-2 (VEGFR2) is a major regulator of endothelial cell (EC) functions, including angiogenesis. Although most studies of angiogenesis focus on soluble VEGF signaling, mechanical signaling also plays a critical role. Here, we examined the consequence of disruption of mechanical signaling on soluble signaling pathways. Specifically, we observed that small interfering RNA (siRNA) knockdown of a mechanosensitive ion channel, transient receptor potential vanilloid 4 (TRPV4), significantly reduced perinuclear (Golgi) VEGFR2 in human ECs with a concomitant increase in phosphorylation at Y1175 and membrane translocation. TRPV4 knockout (KO) ECs exhibited increased plasma membrane localization of phospho-VEGFR2 compared with normal ECs. The knockdown also increased phospho-VEGFR2 in whole cell lysates and membrane fractions compared with control siRNA-treated cells. siRNA knockdown of TRPV4 enhanced nuclear localization of mechanosensitive transcription factors, yes-associated protein/transcriptional coactivator with PDZ-binding motif via rho kinase, which were shown to increase VEGFR2 trafficking to the plasma membrane. Furthermore, TRPV4 deletion/knockdown enhanced VEGF-mediated migration in vitro and increased expression of VEGFR2 in vivo in the vasculature of TRPV4 KO tumors compared with wild-type tumors. Our results thus show that TRPV4 channels regulate VEGFR2 trafficking and activation to identify novel cross-talk between mechanical (TRPV4) and soluble (VEGF) signaling that controls EC migration and angiogenesis.-Kanugula, A. K., Adapala, R. K., Midha, P., Cappelli, H. C., Meszaros, J. G., Paruchuri, S., Chilian, W. M., Thodeti, C. K., Novel noncanonical regulation of soluble VEGF/VEGFR2 signaling by mechanosensitive ion channel TRPV4.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1096/fj.201800509R" target="_blank" rel="noreferrer noopener">10.1096/fj.201800509R</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2019
Adapala Ravi K
angiogenesis
Cappelli Holly C
Chilian William M
Department of Integrative Medical Sciences
endothelial cell
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Kanugula Anantha K
Meszaros J Gary
Midha Priya
NEOMED College of Medicine
Paruchuri Sailaja
Phosphorylation
Thodeti Charles K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.canlet.2018.07.042" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.canlet.2018.07.042</a>
Pages
15–20
Volume
442
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mechanosensitive TRPV4 channels stabilize VE-cadherin junctions to regulate tumor vascular integrity and metastasis.
Publisher
An entity responsible for making the resource available
Cancer letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-02
Subject
The topic of the resource
Angiogenesis; Mechanotransduction; Stiffness; TRPV4; Vascular integrity; VE-cadherin
Creator
An entity primarily responsible for making the resource
Cappelli Holly C; Kanugula Anantha K; Adapala Ravi K; Amin Vibhatsu; Sharma Priya; Midha Priya; Paruchuri Sailaja; Thodeti Charles K
Description
An account of the resource
The transient receptor potential vanilloid 4 (TRPV4) channel is a mechanosensor in endothelial cells (EC) that regulates cyclic strain-induced reorientation and flow-mediated nitric oxide production. We have recently demonstrated that TRPV4 expression is reduced in tumor EC and tumors grown in TRPV4KO mice exhibited enhanced growth and immature leaky vessels. However, the mechanism by which TRPV4 regulates tumor vascular integrity and metastasis is not known. Here, we demonstrate that VE-cadherin expression at the cell-cell contacts is significantly reduced in TRPV4-deficient tumor EC and TRPV4KO EC. In vivo angiogenesis assays with Matrigel of varying stiffness (700-900Pa) revealed a significant stiffness-dependent reduction in VE-cadherin-positive vessels in Matrigel plugs from TRPV4KO mice compared with WT mice, despite an increase in vessel growth. Further, syngeneic Lewis Lung Carcinomatumor experiments demonstrated a significant decrease in VE-cadherin positive vessels in TRPV4KO tumors compared with WT. Functionally, enhanced tumor cell metastasis to the lung was observed in TRPV4KO mice. Our findings demonstrate that TRPV4 channels regulate tumor vessel integrity by maintaining VE-cadherin expression at cell-cell contacts and identifies TRPV4 as a novel target for metastasis.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.canlet.2018.07.042" target="_blank" rel="noreferrer noopener">10.1016/j.canlet.2018.07.042</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2019
Adapala Ravi K
Amin Vibhatsu
angiogenesis
Cancer letters
Cappelli Holly C
Department of Integrative Medical Sciences
Kanugula Anantha K
Mechanotransduction
Midha Priya
NEOMED College of Medicine
Paruchuri Sailaja
Sharma Priya
Stiffness
Thodeti Charles K
TRPV4
Vascular integrity
VE-cadherin