1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0197-0186(97)00086-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0197-0186(97)00086-7</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
299-307
Issue
3
Volume
32
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Tamoxifen alters dopamine output through direct actions upon superfused corpus striatal tissue fragments
Publisher
An entity responsible for making the resource available
Neurochemistry International
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-03
Subject
The topic of the resource
breast-cancer; receptor; Biochemistry & Molecular Biology; Neurosciences & Neurology; estrogen; breast-cancer; antagonist; estradiol; nigrostriatal; release; anti-estrogen; antiestrogens; metabolites; brain metastases; sexual-behavior; non-genomic
Creator
An entity primarily responsible for making the resource
McDermott J L; Anderson L I; Dluzen D E
Description
An account of the resource
Tamoxifen (10 pg/ml) was infused directly into superfused striatal tissue fragments of ovariectomized rats for a 50 min period. Immediately following the termination of tamoxifen there was a significant increase in dopamine output compared with non-infused controls. No such significant increase was observed with use of a 100 pg/ml tamoxifen dose. Although dopamine output was again increased upon termination of a 2 h infusion of tamoxifen, these levels failed to differ significantly from that of non-infused controls. Similarly, a shorter 10 min duration infusion of tamoxifen failed to alter dopamine output. Finally, we examined whether the tamoxifen-induced, post-infusion increase in dopamine output, as observed following a 50 min infusion of 10 pg/ml, involved a calcium dependent process. To achieve this goal, superfusions were performed with Calcium/Tamoxifen, No Calcium/Tamoxifen, No Calcium/No Tamoxifen and Calcium/No Tamoxifen. A significant increase in dopamine output post-tamoxifen infusion was obtained for the Calcium/Tamoxifen condition compared with the remaining three groups which failed to differ from one another. Taken together these results show that tamoxifen can alter dopamine output through direct, non-genomic effects upon striatal neurons. Responses to this anti-estrogen are intriguing since they are apparent following removal, but not during tamoxifen infusion and represent a calcium-dependent process. These data suggest that tamoxifen may represent an important modulator of nigrostriatal dopaminergic function. (C) 1998 Elsevier Science Ltd. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0197-0186(97)00086-7" target="_blank" rel="noreferrer noopener">10.1016/s0197-0186(97)00086-7</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1998
Anderson L I
Antagonist
anti-estrogen
antiestrogens
Biochemistry & Molecular Biology
brain metastases
breast-cancer
Dluzen D E
estradiol
estrogen
Journal Article or Conference Abstract Publication
McDermott J L
metabolites
Neurochemistry international
Neurosciences & Neurology
nigrostriatal
non-genomic
Receptor
release
sexual-behavior
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(95)00993-z" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(95)00993-z</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
248-252
Issue
1
Volume
698
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
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Title
A name given to the resource
TAMOXIFEN TREATMENT OF OVARIECTOMIZED MICE ALTERS DOPAMINE RELEASE FROM STRIATAL TISSUE FRAGMENTS SUPERFUSED IN-VITRO
Publisher
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Brain Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-11
Subject
The topic of the resource
rat; therapy; Neurosciences & Neurology; estrogen; metabolism; brain; breast-cancer; estradiol; nigrostriatal; pituitary; antiestrogens; uterus; anti-estrogen; caudate nucleus
Creator
An entity primarily responsible for making the resource
McDermott J L; Liu B J; Dluzen D E
Description
An account of the resource
In this report we examined the effect of tamoxifen upon the nigrostriatal dopaminergic system. Ovariectomized mice were subjected to one of the following treatments: two subcutaneous injections administered on successive days of the sesame oil vehicle (control), estradiol benzoate (EB-10 mu g), tamoxifen citrate (TMX 125 mu g) or a combination of EB + TMX. At 24 h after the second injection, the caudate nucleus was superfused in vitro to evaluate the effects of these treatments upon basal as well as potassium stimulated (30 mM) dopamine release rates. In addition, uteri were weighed from each animal. Basal and total fractional dopamine release rates from the caudate nucleus of control mice were significantly lower than those of the other three treatments, which failed to differ among each other. Potassium minus(-) basal stimulated dopamine release rates failed to differ significantly among the four treatment conditions. Uterine weights of the TMX treated mice were significantly greater than controls, but significantly lower than EB and EB + TMX animals. These data show that TMX can significantly increase caudate nucleus dopamine release to levels observed in EB treated mice. These agonistic effects of TMX upon nigrostriatal dopaminergic function can be contrasted with its relatively weak estrogenic effects upon uterine weights and indicate the discriminatory, system specific effects that can be exerted by this anti-estrogen. This demonstration of TMX's ability to modulate central nervous system function is of particular relevance in light of pending clinical trials for the prophylactic use of TMX in the treatment of women for breast cancer.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(95)00993-z" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(95)00993-z</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1995
anti-estrogen
antiestrogens
Brain
Brain research
breast-cancer
caudate nucleus
Dluzen D E
estradiol
estrogen
Journal Article or Conference Abstract Publication
Liu B J
McDermott J L
Metabolism
Neurosciences & Neurology
nigrostriatal
pituitary
rat
therapy
Uterus