1
40
7
-
Text
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URL Address
<a href="http://doi.org/10.3389/fnsys.2014.00162" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fnsys.2014.00162</a>
Pages
162–162
Volume
8
Dublin Core
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Title
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Developmental hearing loss impairs signal detection in noise: putative central mechanisms.
Publisher
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Frontiers in systems neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
1905-07
Subject
The topic of the resource
masking; auditory cortex; conductive hearing loss; electrophysiology; gerbil; intracellular; noise; signal detection
Creator
An entity primarily responsible for making the resource
Gay Jennifer D; Voytenko Sergiy V; Galazyuk Alexander V; Rosen Merri J
Description
An account of the resource
Listeners with hearing loss have difficulty processing sounds in noisy environments. This is most noticeable for speech perception, but is reflected in a basic auditory processing task: detecting a tonal signal in a noise background, i.e., simultaneous masking. It is unresolved whether the mechanisms underlying simultaneous masking arise from the auditory periphery or from the central auditory system. Poor detection in listeners with sensorineural hearing loss (SNHL) is attributed to cochlear hair cell damage. However, hearing loss alters neural processing in the central auditory system. Additionally, both psychophysical and neurophysiological data from normally hearing and impaired listeners suggest that there are additional contributions to simultaneous masking that arise centrally. With SNHL, it is difficult to separate peripheral from central contributions to signal detection deficits. We have thus excluded peripheral contributions by using an animal model of early conductive hearing loss (CHL) that provides auditory deprivation but does not induce cochlear damage. When tested as adults, animals raised with CHL had increased thresholds for detecting tones in simultaneous noise. Furthermore, intracellular in vivo recordings in control animals revealed a cortical correlate of simultaneous masking: local cortical processing reduced tone-evoked responses in the presence of noise. This raises the possibility that altered cortical responses which occur with early CHL can influence even simple signal detection in noise.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3389/fnsys.2014.00162" target="_blank" rel="noreferrer noopener">10.3389/fnsys.2014.00162</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
auditory cortex
conductive hearing loss
Department of Anatomy & Neurobiology
Electrophysiology
Frontiers in systems neuroscience
Galazyuk Alexander V
Gay Jennifer D
gerbil
intracellular
masking
NEOMED College of Medicine
Noise
Rosen Merri J
signal detection
Voytenko Sergiy V
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0051646" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0051646</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
18-18
Issue
12
Volume
7
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Title
A name given to the resource
Processing Of Communication Calls In Guinea Pig Auditory Cortex
Publisher
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Plos One
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-12
Subject
The topic of the resource
Acoustic noise; Action potentials; Anesthesia; Auditory cortex; Brain research; Broadband; Communication; conspecific; Auditory cortex; Cortex (temporal); cortical discrimination; Councils; functional specialization; Guinea pigs; Localization; Macaque; Medical research; Monkeys; neural representation; Neurobiology; neurons; Neurosciences; Ohio; purr call; rhesus-monkey; Saimiri; Science & Technology - Other Topics; Sciences: Comprehensive Works; single neurons; social vocalizations; Sound; species-specific vocalizations; squirrel-monkeys; Stimuli; United Kingdom--UK; Urethane; Vocalization; vocalizations
Creator
An entity primarily responsible for making the resource
Grimsley J M S; Shanbhag S J; Palmer A R; Wallace M N
Description
An account of the resource
Vocal communication is an important aspect of guinea pig behaviour and a large contributor to their acoustic environment. We postulated that some cortical areas have distinctive roles in processing conspecific calls. In order to test this hypothesis we presented exemplars from all ten of their main adult vocalizations to urethane anesthetised animals while recording from each of the eight areas of the auditory cortex. We demonstrate that the primary area (AI) and three adjacent auditory belt areas contain many units that give isomorphic responses to vocalizations. These are the ventrorostral belt (VRB), the transitional belt area (T) that is ventral to AI and the small area (area S) that is rostral to AI. Area VRB has a denser representation of cells that are better at discriminating among calls by using either a rate code or a temporal code than any other area. Furthermore, 10% of VRB cells responded to communication calls but did not respond to stimuli such as clicks, broadband noise or pure tones. Area S has a sparse distribution of call responsive cells that showed excellent temporal locking, 31% of which selectively responded to a single call. AI responded well to all vocalizations and was much more responsive to vocalizations than the adjacent dorsocaudal core area. Areas VRB, AI and S contained units with the highest levels of mutual information about call stimuli. Area T also responded well to some calls but seems to be specialized for low sound levels. The two dorsal belt areas are comparatively unresponsive to vocalizations and contain little information about the calls. AI projects to areas S, VRB and T, so there may be both rostral and ventral pathways for processing vocalizations in the guinea pig.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0051646" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0051646</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
Acoustic noise
Action Potentials
Anesthesia
auditory cortex
Brain research
Broadband
Communication
conspecific
Cortex (temporal)
cortical discrimination
Councils
functional specialization
Grimsley J M S
Guinea Pigs
Journal Article or Conference Abstract Publication
localization
Macaque
MEDICAL research
monkeys
neural representation
Neurobiology
Neurons
Neurosciences
Ohio
Palmer A R
PloS one
purr call
rhesus-monkey
saimiri
Science & Technology - Other Topics
Sciences: Comprehensive Works
Shanbhag S J
single neurons
social vocalizations
Sound
species-specific vocalizations
squirrel-monkeys
Stimuli
United Kingdom--UK
Urethane
Vocalization
vocalizations
Wallace M N
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fnana.2013.00013" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fnana.2013.00013</a>
Pages
13–13
Volume
7
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ultrastructural examination of the corticocollicular pathway in the guinea pig: a study using electron microscopy, neural tracers, and GABA immunocytochemistry.
Publisher
An entity responsible for making the resource available
Frontiers in neuroanatomy
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013
Subject
The topic of the resource
auditory cortex; bouton classification; corticofugal pathways; inferior colliculi; synaptic targets; ultrastructural variations
Creator
An entity primarily responsible for making the resource
Nakamoto Kyle T; Mellott Jeffrey G; Killius Jeanette; Storey-Workley Megan E; Sowick Colleen S; Schofield Brett R
Description
An account of the resource
Projections from auditory cortex (AC) can alter the responses of cells in the inferior colliculus (IC) to sounds. Most IC cells show excitation and inhibition after stimulation of the AC. AC axons release glutamate and excite their targets, so inhibition is presumed to result from cortical activation of GABAergic IC cells that inhibit other IC cells via local projections. However, it is not known whether cortical axons contact GABAergic IC cells directly. We labeled corticocollicular axons by injecting fluorescent dextrans into the AC in guinea pigs. We visualized the tracer with diaminobenzidine and processed the tissue for electron microscopy. We identified presumptive GABAergic profiles with post-embedding anti-GABA immunogold histochemistry on ultrathin sections. We identified dextran-labeled cortical boutons in the IC and identified their postsynaptic targets according to morphology (e.g., spine, dendrite) and
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3389/fnana.2013.00013" target="_blank" rel="noreferrer noopener">10.3389/fnana.2013.00013</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
auditory cortex
bouton classification
corticofugal pathways
Department of Anatomy & Neurobiology
Frontiers in neuroanatomy
inferior colliculi
Killius Jeanette
Mellott Jeffrey G
Nakamoto Kyle T
NEOMED College of Medicine
Schofield Brett R
Sowick Colleen S
Storey-Workley Megan E
synaptic targets
ultrastructural variations
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2013.10.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2013.10.003</a>
Pages
131–144
Volume
306
Dublin Core
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Title
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Auditory cortical axons contact commissural cells throughout the guinea pig inferior colliculus.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-12
Subject
The topic of the resource
AC; Animals; auditory cortex; Auditory Cortex/*physiology; Auditory Pathways/cytology; Axons/metabolism/*pathology; Brain Mapping; cortical layers; Fast Blue; FB; FD; Female; FG; Fluor0Ruby; fluorescein dextran; Fluorescence; FluoroGold; FR; G-; G+; GAD; GAD-immunonegative; GAD-immunopositive; GAD-neg; gamma-Aminobutyric Acid/metabolism; GB; Glutamate Decarboxylase/metabolism; glutamic acid decarboxylase; green RetroBeads; Guinea Pigs; I-VI; IC; IC central nucleus; IC dorsal cortex; IC lateral cortex; IC rostral cortex; ICc; ICd; IClc; ICrc; Inferior Colliculi/pathology/*physiology; inferior colliculus; Male; Mesencephalon/pathology; Microscopy; ps; pseudosylvian sulcus; rhinal sulcus; rs; white matter; wm
Creator
An entity primarily responsible for making the resource
Nakamoto Kyle T; Sowick Colleen S; Schofield Brett R
Description
An account of the resource
Projections from auditory cortex (AC) affect how cells in both inferior colliculi (IC) respond to acoustic stimuli. The large projection from the AC to the ipsilateral IC is usually credited with the effects in the ipsilateral IC. The circuitry underlying effects in the contralateral IC is less clear. The direct projection from the AC to the contralateral IC is relatively small. An unexplored possibility is that the large ipsilateral cortical projection contacts the substantial number of cells in the ipsilateral IC that project through the commissure to the contralateral IC. Apparent contacts between cortical boutons and commissural cells were identified in the left IC after injection of different fluorescent tracers into the left AC and the right IC. Commissural cells were labeled throughout the left IC, and many (23-34%) appeared to be contacted by cortical axons. In the central nucleus, both disc-shaped and stellate cells were contacted. Antibodies to glutamic acid decarboxylase (GAD) were used to identify GABAergic commissural cells. The majority (\textgreater86%) of labeled commissural cells were GAD-immunonegative. Despite low numbers of GAD-immunopositive commissural cells, some of these cells were contacted by cortical boutons. Nonetheless, most cortically contacted commissural cells were GAD-immunonegative (i.e., presumably glutamatergic). We conclude that auditory cortical axons contact primarily excitatory commissural cells in the ipsilateral IC that project to the contralateral IC. These corticocollicular contacts occur in each subdivision of the ipsilateral IC, suggesting involvement of commissural cells throughout the IC. This pathway - from AC to commissural cells in the ipsilateral IC - is a prime candidate for the excitatory effects of activation of the auditory cortex on responses in the contralateral IC. Overall this suggests that the auditory corticofugal pathway is integrated with midbrain commissural connections.
Identifier
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<a href="http://doi.org/10.1016/j.heares.2013.10.003" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2013.10.003</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
AC
Animals
auditory cortex
Auditory Cortex/*physiology
Auditory Pathways/cytology
Axons/metabolism/*pathology
Brain Mapping
cortical layers
Department of Anatomy & Neurobiology
Fast Blue
FB
FD
Female
FG
Fluor0Ruby
fluorescein dextran
Fluorescence
FluoroGold
FR
G-
G+
GAD
GAD-immunonegative
GAD-immunopositive
GAD-neg
gamma-Aminobutyric Acid/metabolism
GB
Glutamate Decarboxylase/metabolism
glutamic acid decarboxylase
green RetroBeads
Guinea Pigs
Hearing research
I-VI
IC
IC central nucleus
IC dorsal cortex
IC lateral cortex
IC rostral cortex
ICc
ICd
IClc
ICrc
Inferior Colliculi/pathology/*physiology
inferior colliculus
Male
Mesencephalon/pathology
Microscopy
Nakamoto Kyle T
NEOMED College of Medicine
ps
pseudosylvian sulcus
rhinal sulcus
rs
Schofield Brett R
Sowick Colleen S
white matter
wm
-
Text
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URL Address
<a href="http://doi.org/10.1111/j.1749-6632.2011.06023.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1749-6632.2011.06023.x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
142-154
Volume
1225
Search for Full-text
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Title
A name given to the resource
Taking advantage of behavioral changes during development and training to assess sensory coding mechanisms
Publisher
An entity responsible for making the resource available
New Perspectives on Neurobehavioral Evolution
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011
Subject
The topic of the resource
amplitude-modulation; auditory cortex; awake macaques; contrast sensitivity; cortex; development; discrimination; gerbil; mongolian; neurophysiology; perception; perceptual; primary auditory-cortex; primate prefrontal; receptive-field plasticity; sound-localization; temporal resolution; training
Creator
An entity primarily responsible for making the resource
Sarro E C; Rosen M J; Sanes D H
Description
An account of the resource
The relationship between behavioral and neural performance has been explored in adult animals, but rarely during the developmental period when perceptual abilities emerge. We used these naturally occurring changes in auditory perception to evaluate underlying encoding mechanisms. Performance of juvenile and adult gerbils on an amplitude modulation (AM) detection task was compared with response properties from auditory cortex of age-matched animals. When tested with an identical behavioral procedure, juveniles display poorer AM detection thresholds than adults. Two neurometric analyses indicate that the most sensitive juvenile and adult neurons have equivalent AM thresholds. However, a pooling neurometric revealed that adult cortex encodes smaller AM depths. By each measure, neural sensitivity was superior to psychometric thresholds. However, juvenile training improved adult behavioral thresholds, such that they verged on the best sensitivity of adult neurons. Thus, periods of training may allow an animal to use the encoded information already present in cortex.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1749-6632.2011.06023.x" target="_blank" rel="noreferrer noopener">10.1111/j.1749-6632.2011.06023.x</a>
Format
The file format, physical medium, or dimensions of the resource
Book Section
2011
amplitude-modulation
auditory cortex
awake macaques
Book Section
contrast sensitivity
cortex
development
Discrimination
gerbil
mongolian
Neurophysiology
New Perspectives on Neurobehavioral Evolution
Perception
perceptual
primary auditory-cortex
primate prefrontal
receptive-field plasticity
Rosen M J
Sanes D H
Sarro E C
sound-localization
temporal resolution
Training
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1017/s0140525x98531172" target="_blank" rel="noreferrer noopener">http://doi.org/10.1017/s0140525x98531172</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
286-+
Issue
2
Volume
21
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Title
A name given to the resource
Combination-sensitive neurons: A flexible neural strategy for analyzing correlated elements in sounds - Open peer commentary
Publisher
An entity responsible for making the resource available
Behavioral and Brain Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-04
Subject
The topic of the resource
auditory cortex; Behavioral Sciences; moustached bat; Neurosciences & Neurology; Psychology
Creator
An entity primarily responsible for making the resource
Wenstrup J J
Description
An account of the resource
Combination-sensitive neurons serve as the fundamental processing unit in Sussman and colleagues' proposal for the neural representation of of stop consonants. This commentary describes recent studies in the mustached bat that show how ubiquitous and flexible this neural strategy can be. Sussman et al.'s proposal is an important contribution to a neuroethological consideration of speech perception.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1017/s0140525x98531172" target="_blank" rel="noreferrer noopener">10.1017/s0140525x98531172</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1998
auditory cortex
Behavioral and Brain Sciences
Behavioral Sciences
Journal Article
moustached bat
Neurosciences & Neurology
Psychology
Wenstrup J J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
4693-4711
Issue
6
Volume
15
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
INPUTS TO COMBINATION-SENSITIVE NEURONS IN THE MEDIAL GENICULATE-BODY OF THE MOUSTACHED BAT - THE MISSING FUNDAMENTAL
Publisher
An entity responsible for making the resource available
Journal of Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-06
Subject
The topic of the resource
auditory cortex; auditory pathways; auditory cortex; bat; biosonar; biosonar signals; combination sensitive; complex sounds; echolocating bat; functional-organization; inferior colliculus; medial geniculate body; moustached; Neurosciences & Neurology; pteronotus-p-parnellii; range; representation; single units; target
Creator
An entity primarily responsible for making the resource
Wenstrup J J; Grose C D
Description
An account of the resource
This study examined projections to combination-sensitive neurons in the medial geniculate body of the mustached bat, These specialized neurons respond to the combination of two temporally and spectrally distinct components of the bat's sonar pulse and echo, encoding target information, Combination-sensitive neurons respond to the bat's sonar fundamental, between 24-31 kHz, in conjunction with a higher harmonic signal, They are thought to be formed in the medial geniculate body (MGB) by convergent input from inferior colliculus representations of 24-31 kHz and higher frequencies, This study used anterograde and retrograde tract-tracing methods in conjunction with physiological recording to test this MGB convergence hypothesis. In anterograde tracing experiments, multiple deposits of two different tracers were placed in the central nucleus of the inferior colliculus (ICC), one tracer in the 24-31 kHz region and another in an ICC representation responding to a higher sonar harmonic, We found only limited overlap in the MGB labeling patterns of the two tracers, and little in many areas where combination-sensitive neurons are common, In retrograde tracing experiments, a single deposit of tracer was placed at a combination-sensitive recording site in the MGB, With the deposit mostly limited to combination-sensitive MGB areas, labeling in 24-31 kHz representations of the ICC was absent or minor, These results suggest that many combination-sensitive neurons in the MGB do not receive 24-31 kHz ICC input. The strongest inputs to combination-sensitive MGB regions originate in high-frequency representations of the ICC and combination-sensitive regions of auditory cortex, Additional projections arrive from the thalamic reticular nucleus, external nucleus of the inferior colliculus, and pericollicular tegmentum, Each projection may contribute to the 24-31 kHz sensitivity of combination-sensitive neurons in the medial geniculate body.
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1995
auditory cortex
Auditory Pathways
bat
biosonar
biosonar signals
combination sensitive
complex sounds
echolocating bat
functional-organization
Grose C D
inferior colliculus
Journal Article
Journal of Neuroscience
medial geniculate body
moustached
Neurosciences & Neurology
pteronotus-p-parnellii
range
representation
single units
target
Wenstrup J J