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Text
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URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2009.11.070" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2009.11.070</a>
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Pages
1490-1500
Issue
4
Volume
165
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Title
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SUPPRESSION OF SPONTANEOUS FIRING IN INFERIOR COLLICULUS NEURONS DURING SOUND PROCESSING
Publisher
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Neuroscience
Date
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2010
2010-02
Subject
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auditory-nerve fibers; awake animal; awake bats; bat; crossed olivocochlear bundle; electrical-stimulation; frequency modulated sweep; guinea-pigs; hair-cells; intracellular recording; intracellular-recordings; IPSP; Neurosciences & Neurology; nucleus; postsynaptic potentials; signal-to-noise ratio; somatosensory systems; ventral cochlear
Creator
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Voytenko S V; Galazyuk A V
Description
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Spontaneous activity is a well-known neural phenomenon that occurs throughout the brain and is essential for normal development of auditory circuits and for processing of sounds. Spontaneous activity could interfere with sound processing by reducing the signal-to-noise ratio. Multiple studies have reported that spontaneous activity in auditory neurons can be suppressed by sound stimuli. The goal of this study was to determine the stimulus conditions that cause this suppression and to identify possible underlying mechanisms. Experiments were conducted in the inferior colliculus (IC) of awake little brown bats using extracellular and intracellular recording techniques. The majority of IC neurons (82%) fired spontaneously, with a median spontaneous firing rate of 6 spikes/s. After offset of a 4 ms sound, more than half of these neurons exhibited suppression of spontaneous firing that lasted hundreds of milliseconds. The duration of suppression increased with sound level. Intracellular recordings showed that a short (<50 ms) membrane hyperpolarization was often present during the beginning of suppression, but it was never observed during the remainder of the suppression. Beyond the initial 50 ms period, the absence of significant changes in input resistance during suppression suggests that suppression is presynaptic in origin. Namely, it may occur on presynaptic terminals and/or elsewhere on presynaptic neurons. Suppression of spontaneous firing may serve as a mechanism for enhancing signal-to-noise ratios during signal processing. Published by Elsevier Ltd on behalf of IBRO.
Identifier
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<a href="http://doi.org/10.1016/j.neuroscience.2009.11.070" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2009.11.070</a>
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Journal Article
2010
auditory-nerve fibers
awake animal
awake bats
bat
crossed olivocochlear bundle
electrical-stimulation
frequency modulated sweep
Galazyuk A V
guinea-pigs
hair-cells
intracellular recording
intracellular-recordings
IPSP
Journal Article
Neuroscience
Neurosciences & Neurology
nucleus
postsynaptic potentials
Signal-To-Noise Ratio
somatosensory systems
ventral cochlear
Voytenko S V