Adult mixed sex Cyp1b1–/– [129S6.129 × 1(B6)-Cyp1b1TM1Gonz/Mmnc] mice were obtained from the Mutant Mouse Resource and Research Center (MMRRC) at JAX (Jackson Laboratories) and genotyped before experimentation to confirm the transgene. These mice…
Mutations in the cytochrome P450-1B1 (Cyp1b1) gene is a common genetic predisposition associated with various human glaucomas, most prominently in primary congenital glaucoma (PCG). The role of Cyp1b1 in the eye is largely unknown, however, its…
