Longitudinal assessment of quality of life and lifestyle in newly diagnosed ovarian cancer patients: The roles of surgery and chemotherapy
alternative medicine use; behaviors; breast-cancer; chemotherapy; complementary and alternative medicine; complementary/alternative; energy-balance; functional assessment; gynecologic; medicine; Obstetrics & Gynecology; Oncology; Oncology; ovarian-cancer; quality-of-life; receiving adjuvant chemotherapy; Surgery; trial; women
Objectives. To prospectively evaluate quality of life (QoL), use of complementary and alternative medicine (CAM), and diet/exercise changes in ovarian cancer patients during the first 6 months following diagnosis. Methods. Patients with newly diagnosed ovarian cancer were enrolled pre- or post-operatively and surveyed at 3 and 6 months. The Functional Assessment of Cancer Therapy (FACT-G), Medical Outcomes Survey (SF-36), and CAM/diet/exercise questionnaires were used. Independent samples t test and repeated measures ANOVA were used. Results. Forty-two patients underwent surgical debulking and staging prior to chemotherapy. Patients completing the initial surveys post-operatively had significantly lower physical FACT-G and SF-36 physical scores compared to patients completing the surveys pre-operatively. In patients completing the baseline survey pre-operatively, there was a decrease in physical scores at 3 months (after surgery and during chemotherapy). There was no change observed at 3 months relative to baseline when patients completed the baseline survey post-operatively. Increases in physical and functional well-being were seen at 6 months relative to 3 months. There were no changes in emotional or social scores over time. CAM use increased over time; main reasons were to improve QoL and relieve symptoms. Alterations in diet and exercise were not seen. Conclusions. These data highlight the need to conduct assessments before and after surgery to identify effects due to surgery and/or chemotherapy. Patients may be using CAM during chemotherapy to deal with symptoms and compensate for decreased QoL. Intervention trials should be implemented to increase QoL following surgery and during adjuvant chemotherapy. (c) 2006 Elsevier Inc. All rights reserved.
Von Gruenigen V E; Frasure H E; Jenison E L; Hopkins M P; Gil K M
Gynecologic Oncology
2006
2006-10
Journal Article
<a href="http://doi.org/10.1016/j.ygyno.2006.01.059" target="_blank" rel="noreferrer noopener">10.1016/j.ygyno.2006.01.059</a>
Assessing dietary and exercise stage of change to optimize weight loss interventions
assessment; behaviors; diet and exercise; Endocrinology & Metabolism; expert-system intervention; fat; minority women; model; nutrient database; Nutrition & Dietetics; obesity; older-adults; physical-activity; population; smoking cessation; stage of change; Transtheoretical; weight loss intervention
Objective: According to the Transtheoretical Model (TM), tailoring interventions to patients' readiness to change can enhance patient progress and help patients use therapeutic resources more effectively. However, tailoring an intervention depends on accurate assessment of patients' stage of change (SOC). This study describes a multi-item algorithm of SOC (M-SOC) for weight loss-related behaviors that attempts to overcome some of the conceptual and methodological difficulties encountered in previously SOC assessments. Research Methods: Data were collected from participants randomly assigned to the treatment arm of a clinical trial comparing a TM-based, cognitive-behavioral intervention with enhanced usual care for weight loss. Results: The stair-step relationships hypothesized by the TM between assessed SOC and key behavioral measures were found for all algorithms (p < 0.05), indicating that the M-SOC algorithm performs as well as single item algorithms. However, 50% fewer patients were classified in action or maintenance for dietary fat intake and portion control (p < 0.05) by the multiple-item algorithms, providing staging more consistent with the clinical presentation of obese individuals. In addition, logistic regression analyses indicated that the single-item algorithms were not sufficient predictors of these behavioral domains. Discussion: To the extent that treatment is guided by assessed SOC, there is potential for a considerable variability in interventions with different approaches to staging. For weight-loss interventions that target portion control and decreased fat intake, the multi-item SOC algorithms seem to be better guides for matching treatments to SOC.
Sutton K; Logue E; Jarjoura D; Baughman K; Smucker W; Capers C
Obesity Research
2003
2003-05
Journal Article
<a href="http://doi.org/10.1038/oby.2003.92" target="_blank" rel="noreferrer noopener">10.1038/oby.2003.92</a>
Cancer-related knowledge, beliefs, and behaviors among Hispanic/Latino residents of Indiana
Background: Cancer is the leading cause of death for Hispanics in the USA. Screening and prevention reduce cancer morbidity and mortality.
Methods: This study administered a cross-sectional web-based survey to self-identified Hispanic residents in the state of Indiana to assess their cancer-related knowledge, beliefs, and behaviors, as well as to identify what factors might be associated with cancer screening and prevention. Chi-square and Fisher's exact test were used to compare associations and logistic regression used to develop both univariate and multivariate regression models.
Results: A total of 1520 surveys were completed, median age of respondents was 53, 52% identified as men, 50.9% completed the survey in Spanish, and 60.4% identified the USA as their country of birth. Most were not able to accurately identify ages to begin screening for breast, colorectal, or lung cancer, and there were significant differences in cancer knowledge by education level. US-born individuals with higher income and education more often believed they were likely to develop cancer and worry about getting cancer. Sixty eight percent of respondents were up-to-date with colorectal, 44% with breast, and 61% with cervical cancer screening. Multivariate models showed that higher education, lack of fatalism, older age, lower household income, and unmarried status were associated with cervical cancer screening adherence.
Conclusions: Among a Hispanic population in the state of Indiana, factors associated with cervical cancer screening adherence were similar to the general population, with the exceptions of income and marital status. Younger Hispanic individuals were more likely to be adherent with breast and colorectal cancer screening, and given the higher incidence of cancer among older individuals, these results should guide future research and targeted outreach.
Manuel R Espinoza-Gutarra
Susan M Rawl
Gerardo Maupome
Heather A O'Leary
Robin E Valenzuela
Caeli Malloy
Lilian Golzarri-Arroyo
Erik Parker
Laura Haunert
David A Haggstrom
Cancer Med
. 2023 Jan 22. doi: 10.1002/cam4.5466. Online ahead of print.
2023
English
Invivo Changes In Responsiveness Of The Caudate-nucleus To L-dopa Infusion As A Function Of The Estrous-cycle
behaviors; caudate nucleus; corpus striatum; dopamine; estrous-cycle; female rats; hormone; in-vitro; l-dihydroxyphenylalanine; Neurosciences & Neurology; progesterone; prolactin; push-pull perfusion; rat striatum; release; sex-differences
Dluzen D E; Ramirez V D
Brain Research
1990
1990-12
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/0006-8993(90)90021-3" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(90)90021-3</a>