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Text
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URL Address
<a href="http://doi.org/10.1111/j.1751-7915.2011.00278.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1751-7915.2011.00278.x</a>
Pages
203–213
Issue
2
Volume
5
Dublin Core
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Title
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J-LEAPS peptide and LEAPS dendritic cell vaccines.
Publisher
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Microbial biotechnology
Date
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2012
2012-03
Subject
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Antigens/genetics/*immunology; Autoimmune Diseases/therapy; beta 2-Microglobulin/genetics/*immunology; Communicable Disease Control/methods; Dendritic Cells/*immunology; Humans; Immunotherapy/*methods; Neoplasms/therapy; Recombinant Fusion Proteins/genetics/immunology
Creator
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Rosenthal Ken S; Taylor Patricia; Zimmerman Daniel H
Description
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The J-LEAPS vaccines contain a peptide from beta-2-microglobulin covalently attached to disease-related peptides of 8-30 amino acids which contain a T cell epitope. The J-LEAPS vaccines can initiate a protective Th1 immune response or modulate an ongoing Th17 autoimmune response to the peptide. J-LEAPS vaccines activate and direct the nature of the subsequent immune response by promoting the maturation of precursor cells into a unique type of dendritic cell that produces interleukin 12, but not IL-1 or tumour necrosis factor, and presents the antigenic peptide to T cells. Adoptive transfer of JgD-LEAPS dendritic cells, matured with an anti-HSV-1 vaccine, promoted antigen-specific Th1 protection against lethal challenge with the virus. J-LEAPS peptide immunogens and J-LEAPS dendritic cell vaccines have potential applications for antimicrobial prevention and therapy, treatment of autoimmune diseases, and for cancer immunotherapy.
Identifier
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<a href="http://doi.org/10.1111/j.1751-7915.2011.00278.x" target="_blank" rel="noreferrer noopener">10.1111/j.1751-7915.2011.00278.x</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Antigens/genetics/*immunology
Autoimmune Diseases/therapy
beta 2-Microglobulin/genetics/*immunology
Communicable Disease Control/methods
Dendritic Cells/*immunology
Humans
Immunotherapy/*methods
Microbial biotechnology
Neoplasms/therapy
Recombinant Fusion Proteins/genetics/immunology
Rosenthal Ken S
Taylor Patricia
Zimmerman Daniel H