1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Pages 264–271 Issue 1 Volume 7 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Overexpression of beta-catenin and cyclinD1 predicts a poor prognosis in ovarian serous carcinomas. Publisher An entity responsible for making the resource available International journal of clinical and experimental pathology Date A point or period of time associated with an event in the lifecycle of the resource 2014 1905-07 Subject The topic of the resource Adult; Female; Humans; Middle Aged; Aged; Young Adult; Immunohistochemistry; Neoplasm Staging; Prognosis; Kaplan-Meier Estimate; Up-Regulation; Biomarkers; beta-catenin; beta Catenin/analysis/*biosynthesis; Cyclin D1/analysis/*biosynthesis; cyclinD1; Ovarian Neoplasms/*metabolism/mortality/pathology; ovarian serous carcinoma; prognosis; Cystadenocarcinoma; Serous/*metabolism/mortality/pathology; Tumor/*analysis Creator An entity primarily responsible for making the resource Wang Hai; Wang Haiyan; Makki Mohammad Shahidul; Wen Juanjuan; Dai Yingqing; Shi Qunli; Liu Qi; Zhou Xiaojun; Wang Jiandong Description An account of the resource UNLABELLED: Ovarian serous cancer is the most common subtype of epithelial ovarian cancer, and is the leading cause of death from gynecologic cancer. There is an important need for exploration of diagnostic and prognostic markers for this disease. beta-catenin and cyclinD1 play central roles in the tumorigenesis for certain cancers. The role of beta-catenin and cyclinD1 in diagnosis and prognosis of ovarian serous carcinoma is uncertain. In the present study, the expression of beta-catenin and cyclinD1 was examined in 60 ovarian serous carcinomas patients with immunohistochemical staining. The relationship between expression of beta-catenin and cyclinD1 and FIGO stage, pathological grade was analyzed. Kaplan-Meier survival function was used to analyze the prognosis. Overexpression of beta-catenin is more often detected in patients with FIGO stage III and IV than in those with stage I, and II (P=0.003). No significant relationship was found between expression of beta-catenin and pathological grade (P=0.817). Positive expression of beta-catenin related to lower survival rate (P=0.034). The expression of cyclinD1 had no relationship with FIGO stage (P=0.829). Overexpression of cyclinD1 was positively to pathological grade (P=0.017) and survival rate (P=0.009). There is a significantly positive relationship between expression of beta-catenin and cyclinD1 (P=0.014). No statistical significance was found between expression of beta-catenin and cyclinD1 and other pathological parameters. CONCLUSIONS: Expression of beta-catenin and cyclinD1 may be used as predict markers for poor prognosis. Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2014 Adult Aged beta Catenin/analysis/*biosynthesis beta-catenin Biomarkers Cyclin D1/analysis/*biosynthesis cyclinD1 Cystadenocarcinoma Dai Yingqing Female Humans Immunohistochemistry International journal of clinical and experimental pathology Kaplan-Meier Estimate Liu Qi Makki Mohammad Shahidul Middle Aged Neoplasm Staging Ovarian Neoplasms/*metabolism/mortality/pathology ovarian serous carcinoma Prognosis Serous/*metabolism/mortality/pathology Shi Qunli Tumor/*analysis Up-Regulation Wang Hai Wang Haiyan Wang Jiandong Wen Juanjuan Young Adult Zhou Xiaojun