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Text
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URL Address
<a href="http://doi.org/10.1152/ajplung.00022.2006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00022.2006</a>
Pages
L252–256
Issue
2
Volume
291
Dublin Core
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Title
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Impaired alveolar liquid clearance after 48-h isoproterenol infusion spontaneously recovers by 96 h of continuous infusion.
Publisher
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American journal of physiology. Lung cellular and molecular physiology
Date
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2006
2006-08
Subject
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*Pulmonary Alveoli/drug effects/metabolism; Adrenergic; Adrenergic beta-Antagonists/pharmacology; Animals; beta-2/metabolism; Bronchodilator Agents/administration & dosage/*pharmacology; Isoproterenol/administration & dosage/*pharmacology; Lung/drug effects/metabolism; Male; Propranolol/pharmacology; Rats; Receptors; Sprague-Dawley; Terbutaline/pharmacology; Time Factors
Creator
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Maron Michael B; Folkesson Hans G; Stader Sonya M; Hodnichak Cheryl M
Description
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We previously demonstrated that 48-h isoproterenol (Iso) infusion in rats impaired the ability of beta-adrenoceptor (beta-AR) agonists to increase alveolar liquid clearance (ALC). In this study, we determined whether this impairment persisted over longer time periods by infusing 400 mug.kg(-1).h(-1) Iso by osmotic minipump for 24-144 h (n = 6-7/group). ALC in control rats was 19.0 +/- 2.4 (SD)% of instilled volume absorbed per hour. In Iso-infused rats, ALC was elevated at 24 h (34.9 +/- 2.4%) and decreased at 48 h (15.2 +/- 4.4%) and had recovered to 24 h values at 96 h (37.3 +/- 3.8%) and 144 h (35.2 +/- 3.3%). Plasma Iso concentrations remained elevated at all Iso infusion times. Peripheral lung beta(2)-AR expression exhibited a parallel time course, with a reduction in expression observed at 48 h, followed by an increase to 24 h values at 96 and 144 h. Propranolol prevented the increase in ALC observed at 96 and 144 h, indicating that the recovery in ALC was mediated by a recovery of beta-AR function and beta-AR signaling. ALC at 96 and 144 h could not be further increased by terbutaline, indicating that ALC was maximally stimulated. These data indicate that recovery of beta-AR-stimulated ALC can occur in the continued presence of Iso and is mediated by a recovery of the ability of the distal lung epithelium to respond to beta-AR stimulation.
Identifier
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<a href="http://doi.org/10.1152/ajplung.00022.2006" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00022.2006</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Pulmonary Alveoli/drug effects/metabolism
2006
Adrenergic
Adrenergic beta-Antagonists/pharmacology
American journal of physiology. Lung cellular and molecular physiology
Animals
beta-2/metabolism
Bronchodilator Agents/administration & dosage/*pharmacology
Folkesson Hans G
Hodnichak Cheryl M
Isoproterenol/administration & dosage/*pharmacology
Lung/drug effects/metabolism
Male
Maron Michael B
Propranolol/pharmacology
Rats
Receptors
Sprague-Dawley
Stader Sonya M
Terbutaline/pharmacology
Time Factors