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Text
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URL Address
<a href="http://doi.org/10.1086/324526" target="_blank" rel="noreferrer noopener">http://doi.org/10.1086/324526</a>
Pages
S17–26
Volume
34 Suppl 1
Dublin Core
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Title
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Appropriate use of antimicrobials for drug-resistant pneumonia: focus on the significance of beta-lactam-resistant Streptococcus pneumoniae.
Publisher
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Date
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2002
2002-03
Subject
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*beta-Lactam Resistance; beta-Lactams/economics/*therapeutic use; Contraindications; Humans; Pneumococcal/*drug therapy/economics/pathology; Pneumonia; Practice Guidelines as Topic; Streptococcus pneumoniae/*drug effects/metabolism
Creator
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File Thomas M Jr
Description
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The beta-lactam antibiotics (penicillins and cephalosporins) are commonly prescribed for the treatment of community-acquired pneumonia. However, Streptococcus pneumoniae, the most common etiologic agent of community-acquired pneumonia, has become increasingly resistant to beta-lactams over the past decade. The results of several studies suggest that penicillins remain effective for streptococcal pneumonia when the infecting pathogen has a minimal inhibitory concentration (MIC) /=4 microgram/mL, increased rates of mortality (for patients who survive their first 4 days of hospitalization) may occur. Currently, 3.5%-7.8% of S. pneumoniae clinical isolates have MICs that fall in this latter class, but these rates may rise in the future. The clinical relevance of in vitro resistance may be related to at least 3 factors: concordance of antimicrobial therapy, severity of illness, and virulence.
Identifier
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<a href="http://doi.org/10.1086/324526" target="_blank" rel="noreferrer noopener">10.1086/324526</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*beta-Lactam Resistance
2002
beta-Lactams/economics/*therapeutic use
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Contraindications
Department of Internal Medicine
File Thomas M Jr
Humans
NEOMED College of Medicine
Pneumococcal/*drug therapy/economics/pathology
Pneumonia
Practice Guidelines as Topic
Streptococcus pneumoniae/*drug effects/metabolism