Effects Of Exercise On C-reactive Protein In Healthy Patients And In Patients With Heart Disease: A Meta-analysis
Biological; body-composition; Cardiovascular System & Cardiology; cardiovascular-disease; Coronary disease; coronary-artery-disease; exercise; Heart disease; induced weight-loss; Inflammation; inflammatory markers; life-style intervention; marker c-reactive protein; Nursing; obese postmenopausal women; physical-activity; randomized controlled trial; Respiratory System; risk-factors; time
Decreases in circulating hsCRP have been associated with increased physical activity and exercise training, although the ability of exercise interventions to reduce hsCRP and which individuals benefit the most remains unclear. This meta-analysis evaluates the ability of exercise to reduce hsCRP levels in healthy individuals and in individuals with heart disease. A systematic review and meta-analysis was conducted that included exercise interventions trials from 1995 to 2012. Forty-three studies were included in the final analysis for a total of 3575 participants. Exercise interventions significantly reduced hsCRP (standardized mean difference -0.53 mg/L; 95% CI, -0.74 to -0.33). Results of sub-analysis revealed no significant difference in reductions in hsCRP between healthy adults and those with heart disease (p =.20). Heterogeneity between studies could not be attributed to age, gender, intervention length, intervention type, or inclusion of diet modification. Exercise interventions reduced hsCRP levels in adults irrespective of the presence of heart disease. (c) 2016 Elsevier Inc. All rights reserved.
Hammonds T L; Gathright E C; Goldstein C M; Penn M S; Hughes J W
Heart & Lung
2016
2016-05
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/j.hrtlng.2016.01.009" target="_blank" rel="noreferrer noopener">10.1016/j.hrtlng.2016.01.009</a>
HORMONAL-CONTROL OF GROWTH IN THE GENETICALLY-OBESE ZUCKER RAT .1. LINEAR GROWTH, PLASMA INSULIN-LIKE GROWTH FACTOR-I (IGP-I) AND IGF-BINDING PROTEINS
body-composition; developmental-changes; Endocrinology & Metabolism; expression; gh; hepatocytes; messenger-rna; radioimmunoassay; secretion; serum; somatomedin-c
The genetically obese Zucker rat is a widely used model of early-onset obesity. Like obese children, these obese rats are hyperinsulinemic and have low GH secretion. However, data on linear growth and insulin-like growth factor-I (IGF-I) levels in this model are scanty and contradictory. In the present study, we investigated linear growth and its hormonal control in Zucker rats (male and female) from 4-20 weeks of age. In the obese animals, compared to their lean littermates, the naso-anal length was normal or slightly greater, whereas the tails and femurs were shorter. The plasma concentration of IGF-I increased between 4-20 weeks of age, and IGF-I levels were normal or slightly higher in the obese animals. The serum level of IGF-binding protein-3 (IGFBP-3) measured by Western ligand blotting was not significantly different in lean vs, obese rats. To assess the IGF-I response to GH, bovine GH was administered (250 mu g/100 g BW, ip, daily for 3 days) to 16- to 20-week-old female Zucker rats; plasma IGF-I concentrations increased more in the obese (percent increase over baseline, 347 +/- 44% vs. 194 +/- 31%; P < 0.01). These results show that despite low GH secretion, genetically obese Zucker rats have 1) normal linear (nasoanal) growth, 2) normal or increased circulating levels of IGF-I and IGFBP-3, and 3) increased plasma IGF-I responses to exogenous GH. These results suggest that the GH-independent growth in this model could result from direct effects of hyperinsulinism on circulating IGF-I and IGFBP-3 levels and/or indirect effects through increased GH receptor function.
Nguyenyamamoto L; Deal C L; Finkelstein J A; Vanvliet G
Endocrinology
1994
1994-03
Journal Article
<a href="http://doi.org/10.1210/en.134.3.1382" target="_blank" rel="noreferrer noopener">10.1210/en.134.3.1382</a>