1
40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3109/14653249.2012.684380" target="_blank" rel="noreferrer noopener">http://doi.org/10.3109/14653249.2012.684380</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
983-993
Issue
8
Volume
14
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cardiac Pressure Overload Initiates A Systemic Stem Cell Response
Publisher
An entity responsible for making the resource available
Cytotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-09
Subject
The topic of the resource
& Experimental Medicine; acute myocardial-infarction; Biotechnology & Applied Microbiology; bone marrow; bone marrow; cardiac stem cells; cardiomyocytes; Cell Biology; endogenous stem cells; endothelial; endothelial progenitor cells; heart; Hematology; hypertrophy; identification; murine; peripheral-blood; progenitor cells; regeneration; Research; spleen; SSEA-1; transaortic constriction; transplantation
Creator
An entity primarily responsible for making the resource
Finan A; Kiedrowski M; Turturice B A; Sopko N A; Penn M S
Identifier
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<a href="http://doi.org/10.3109/14653249.2012.684380" target="_blank" rel="noreferrer noopener">10.3109/14653249.2012.684380</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
& Experimental Medicine
2012
acute myocardial-infarction
Biotechnology & Applied Microbiology
bone marrow
cardiac stem cells
cardiomyocytes
Cell Biology
Cytotherapy
endogenous stem cells
Endothelial
endothelial progenitor cells
Finan A
heart
Hematology
Hypertrophy
identification
Kiedrowski M
murine
Penn M S
peripheral-blood
progenitor cells
Regeneration
Research
Sopko N A
spleen
SSEA-1
transaortic constriction
Transplantation
Turturice B A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.pharmthera.2019.03.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.pharmthera.2019.03.001</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Alcohol abuse and disorder of granulopoiesis.
Publisher
An entity responsible for making the resource available
Pharmacology & therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-03
Subject
The topic of the resource
*stem cells; Alcohol abuse; Bacterial infection; Bone marrow; Cell signaling; Granulopoiesis; Immune defense; Leukopenia; Progenitor cells; The granulopoietic response
Creator
An entity primarily responsible for making the resource
Shi Xin; DeLucia Angelo L; Bao Jianxin; Zhang Ping
Description
An account of the resource
Granulocytes are the major type of phagocytes constituting the front line of innate immune defense against bacterial infection. In adults, granulocytes are derived from hematopoietic stem cells in the bone marrow. Alcohol is the most frequently abused substance in human society. Excessive alcohol consumption injures hematopoietic tissue, impairing bone marrow production of granulocytes through disrupting homeostasis of granulopoiesis and the granulopoietic response. Because of the compromised immune defense function, alcohol abusers are susceptible to infectious diseases, particularly septic infection. Alcoholic patients with septic infection and granulocytopenia have an exceedingly high mortality rate. Treatment of serious infection in alcoholic patients with bone marrow inhibition continues to be a major challenge. Excessive alcohol consumption also causes diseases in other organ systems, particularly severe alcoholic hepatitis which is life threatening. Corticosteroids are the only therapeutic option for improving short-term survival in patients with severe alcoholic hepatitis. The existence of advanced alcoholic liver diseases and administration of corticosteroids make it more difficult to treat serious infection in alcoholic patients with the disorder of granulopoieis. This article reviews the recent development in understanding alcohol-induced disruption of marrow granulopoiesis and the granulopoietic response with the focus on progress in delineating cell signaling mechanisms underlying the alcohol-induced injury to hematopoietic tissue. Efforts in exploring effective therapy to improve patient care in this field will also be discussed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.pharmthera.2019.03.001" target="_blank" rel="noreferrer noopener">10.1016/j.pharmthera.2019.03.001</a>
*Stem cells
2019
Alcohol abuse
bacterial infection
Bao Jianxin
bone marrow
cell signaling
DeLucia Angelo L
Department of Integrative Medical Sciences
Granulopoiesis
Immune defense
Leukopenia
NEOMED College of Medicine
Pharmacology & therapeutics
progenitor cells
Shi Xin
the granulopoietic response
Zhang Ping
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1074/jbc.M114.624270" target="_blank" rel="noreferrer noopener">http://doi.org/10.1074/jbc.M114.624270</a>
Pages
20128–20146
Issue
33
Volume
290
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Mutation in Osteoactivin Promotes Receptor Activator of NFkappaB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast Function.
Publisher
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The Journal of biological chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-08
Subject
The topic of the resource
*Mutation; Akt; Animals; bone; bone marrow; Bone Remodeling; Cell Differentiation/*physiology; Cell Survival/*physiology; Eye Proteins/*genetics; Inbred DBA; MAP kinases (MAPKs); Membrane Glycoproteins/*genetics; Mice; osteoactivin; osteoclast; Osteoclasts/*cytology; osteopetrosis; RANK Ligand/metabolism/*physiology; Signal Transduction; X-Ray Microtomography
Creator
An entity primarily responsible for making the resource
Abdelmagid Samir M; Sondag Gregory R; Moussa Fouad M; Belcher Joyce Y; Yu Bing; Stinnett Hilary; Novak Kimberly; Mbimba Thomas; Khol Matthew; Hankenson Kurt D; Malcuit Christopher; Safadi Fayez F
Description
An account of the resource
We previously reported on the importance of osteoactivin (OA/Gpnmb) in osteogenesis. In this study, we examined the role of OA in osteoclastogenesis, using mice with a nonsense mutation in the Gpnmb gene (D2J) and wild-type controls (D2J/Gpnmb(+)). In these D2J mice, micro-computed tomography and histomorphometric analyses revealed increased cortical thickness, whereas total porosity and eroded surface were significantly reduced in D2J mice compared with wild-type controls, and these results were corroborated by lower serum levels of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1074/jbc.M114.624270" target="_blank" rel="noreferrer noopener">10.1074/jbc.M114.624270</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Mutation
2015
Abdelmagid Samir M
Akt
Animals
Belcher Joyce Y
Bone
bone marrow
Bone Remodeling
Cell Differentiation/*physiology
Cell Survival/*physiology
Department of Anatomy & Neurobiology
Eye Proteins/*genetics
Hankenson Kurt D
Inbred DBA
Khol Matthew
Malcuit Christopher
MAP kinases (MAPKs)
Mbimba Thomas
Membrane Glycoproteins/*genetics
Mice
Moussa Fouad M
NEOMED College of Medicine
Novak Kimberly
OSTEOACTIVIN
osteoclast
Osteoclasts/*cytology
osteopetrosis
RANK Ligand/metabolism/*physiology
Safadi Fayez F
Signal Transduction
Sondag Gregory R
Stinnett Hilary
The Journal of biological chemistry
X-Ray Microtomography
Yu Bing