1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.nurt.2008.10.035" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.nurt.2008.10.035</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
141-151
Issue
1
Volume
6
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Dual-Target-Directed Drugs that Block Monoamine Oxidase B and Adenosine A(2A) Receptors for Parkinson's Disease
Publisher
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Neurotherapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-01
Subject
The topic of the resource
adenosine A(2A) receptor; antagonist; caffeine; dopaminergic neurotoxicity; dual-target-directed drug; human-brain; inhibition; istradefylline; l-dopa; mao-b; monoamine-oxidase-b; motor complications; Neurosciences & Neurology; parkinsons-disease; Pharmacology & Pharmacy; rat model; substantia-nigra
Creator
An entity primarily responsible for making the resource
Petzer J P; Castagnoli N; Schwarzschild M A; Chen J F; Van der Schyf C J
Description
An account of the resource
Inadequacies of the current pharmacotherapies to treat Parkinson's disease (PD) have prompted efforts to identify novel drug targets. The adenosine A(2A) receptor is one such target. Antagonists of this receptor (A(2A) antagonists) are considered promising agents for the symptomatic treatment of PD. Evidence suggests that A(2A) antagonists may also have neuroprotective properties that may prevent the development of the dyskinesia that often complicates levodopa treatment. Because the therapeutic benefits of A(2A) antagonists are additive to that of dopamine replacement therapy, it may be possible to reduce the dose of the dopaminergic drugs and therefore the occurrence of side effects. Inhibitors of monoamine oxidase (MAO)-B also are considered useful tools for the treatment of PD. When used in combination with levodopa, inhibitors of MAO-B may enhance the elevation of dopamine levels after levodopa treatment, particularly when used in early stages of the disease when dopamine production may not be so severely compromised. Furthermore, MAO-B inhibitors may also possess neuroprotective properties in part by reducing the damaging effect of dopamine turnover in the brain. These effects of MAO-B inhibitors are especially relevant when considering that the brain shows an age-related increase in MAO-B activity. Based on these observations, dual-target-directed drugs, compounds that inhibit MAO-B and antagonize A(2A) receptors, may have value in the management of PD. This review summarizes recent efforts to develop such dual-acting drugs using caffeine as the lead compound.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.nurt.2008.10.035" target="_blank" rel="noreferrer noopener">10.1016/j.nurt.2008.10.035</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2009
adenosine A(2A) receptor
Antagonist
caffeine
Castagnoli N
Chen J F
dopaminergic neurotoxicity
dual-target-directed drug
human-brain
inhibition
istradefylline
Journal Article
l-dopa
mao-b
monoamine-oxidase-b
motor complications
Neurosciences & Neurology
Neurotherapeutics
parkinsons-disease
Petzer J P
Pharmacology & Pharmacy
rat model
Schwarzschild M A
substantia-nigra
Van der Schyf C J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.5664/jcsm.4848" target="_blank" rel="noreferrer noopener">http://doi.org/10.5664/jcsm.4848</a>
Pages
741–746
Issue
7
Volume
11
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Caffeine Awareness in Children: Insights from a Pilot Study.
Publisher
An entity responsible for making the resource available
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-07
Subject
The topic of the resource
Female; Humans; Male; Adolescent; Pilot Projects; Incidence; Child; Cross-Sectional Studies; United States; Surveys and Questionnaires; Age Factors; Sex Factors; Risk Assessment; adolescents; Awareness; Beverages/*adverse effects/statistics & numerical data; caffeine; Caffeine/administration & dosage/*adverse effects; Needs Assessment; sleep; Sleep Wake Disorders/*chemically induced/epidemiology; Students/statistics & numerical data; Practice; *Health Knowledge; Attitudes
Creator
An entity primarily responsible for making the resource
Thakre Tushar P; Deoras Ketan; Griffin Catherine; Vemana Aarthi; Podmore Petra; Krishna Jyoti
Description
An account of the resource
STUDY OBJECTIVES: Caffeine, a commonly consumed psychoactive substance, can have significant effects on sleep. Caffeine intake among children is increasing, mainly in the form of sodas. However, adolescent caffeine consumers may lack knowledge about the caffeine content in common beverages. If true, this very fact may hamper the assessment of the effects of caffeine consumption on sleep in children if such assessments are a priori dependent on responders being able to reliably distinguish between caffeinated and noncaffeinated beverages. This preliminary study investigated adolescents' caffeine knowledge and intake at a Cleveland-area public middle school. METHODS: Seventh- and eighth-grade students were surveyed using: (1) the Caffeine Literacy and Sleep Study (CLASS), a
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.5664/jcsm.4848" target="_blank" rel="noreferrer noopener">10.5664/jcsm.4848</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Health Knowledge
2015
Adolescent
adolescents
Age Factors
Attitudes
Awareness
Beverages/*adverse effects/statistics & numerical data
caffeine
Caffeine/administration & dosage/*adverse effects
Child
Cross-Sectional Studies
Deoras Ketan
Female
Griffin Catherine
Humans
Incidence
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Krishna Jyoti
Male
Needs Assessment
Pilot Projects
Podmore Petra
Practice
Risk Assessment
Sex Factors
sleep
Sleep Wake Disorders/*chemically induced/epidemiology
Students/statistics & numerical data
Surveys and Questionnaires
Thakre Tushar P
United States
Vemana Aarthi