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<a href="http://doi.org/10.1016/j.pediatrneurol.2014.01.043" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.pediatrneurol.2014.01.043</a>
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Pages
586-590
Issue
6
Volume
50
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Title
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Early Hyperglycemia Is Associated With Poor Gross Motor Outcome in Asphyxiated Term Newborns
Publisher
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Pediatric Neurology
Date
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2014
2014-06
Subject
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asphyxia; blood-glucose; cell membrane-function; cerebral-palsy; glucose level; hyperglycemia; hypoxia-ischemia; injury; ischemic brain-damage; metabolism; motor development; Neurosciences & Neurology; newborn full term; outcome; Pediatrics; perinatal asphyxia; stroke
Creator
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Spies E E; Lababidi S L; McBride M C
Description
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BACKGROUND: Hyperglycemia after ischemic stroke in adults and after near-drowning in children is associated with a poor neurological outcome. Anaerobic metabolism of glucose leads to buildup of lactic acid, free radical production, mitochondrial failure, and ultimately an increase in neurological injury. In asphyxiated infants, high lactate peaks are seen in the basal ganglia with magnetic resonance spectroscopy. Because motor disability in asphyxiated full-term newborns often relates to injury in the basal ganglia, we hypothesized that hyperglycemia and associated buildup of lactic acid may lead to worse gross motor outcome. METHODS: Glucose, blood gas values, and demographic data were abstracted from the medical records of 41 term infants with asphyxia and without confounding diagnoses. Their Gross Motor Function Classification System scores were determined from the medical record or by structured telephone interviews. RESULTS: The outcomes of 14 infants were considered poor on the basis of death within the first 6 months or moderate-to-severe cerebral palsy (Gross Motor Function Classification System score 1-5). The other 27 infants had no gross motor disability (Gross Motor Function Classification System score 0). The highest recorded blood glucose correlated with poor outcome (P = 0.046 by logistic regression). Infants with hyperglycemia (blood glucose > 150 mg/dL) were more likely to have poor outcome (P = 0.017; odds ratio: 5.9; 95% confidence interval: 1.4-24.7). CONCLUSIONS: High blood glucose in the first 12 hours is associated with poor gross motor outcome in this cohort of asphyxiated term infants. Clinicians should avoid hyperglycemia in managing term infants with asphyxia.
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<a href="http://doi.org/10.1016/j.pediatrneurol.2014.01.043" target="_blank" rel="noreferrer noopener">10.1016/j.pediatrneurol.2014.01.043</a>
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Journal Article
2014
asphyxia
blood-glucose
cell membrane-function
cerebral-palsy
glucose level
hyperglycemia
hypoxia-ischemia
Injury
ischemic brain-damage
Journal Article
Lababidi S L
McBride M C
Metabolism
motor development
Neurosciences & Neurology
newborn full term
outcome
Pediatric neurology
Pediatrics
perinatal asphyxia
Spies E E
stroke