1
40
2
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Text
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<a href="http://doi.org/10.1097/01.ccm.0000201403.70636.0f" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/01.ccm.0000201403.70636.0f</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
676-681
Issue
3
Volume
34
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine
Publisher
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Critical Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-03
Subject
The topic of the resource
activation; alveolar epithelium; catecholamine; cells; cftr; cystic fibrosis transmembrane conductance regulator; General & Internal Medicine; glibenclamide; injury; liquid clearance; na+ transport; Norepinephrine; pulmonary edema; pulmonary edema; rat; resected human lung; resolution
Creator
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Sakuma T; Gu X; Wang Z; Maeda S; Sugita M; Sagawa M; Osanai K; Toga H; Ware L B; Folkesson G; Matthay M A
Description
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Objectives. Because several experimental studies have demonstrated that cyclic adenosine monophosphate generation following beta-adrenoceptor activation can markedly stimulate alveolar fluid clearance, we determined whether the endogenous levels of catecholamines that occur in the pulmonary edema fluid and plasma of patients with acute lung injury are high enough to stimulate alveolar fluid clearance in the human lung. Design: Observational clinical Study. Setting. Academic university hospital and laboratory. Patients: Twenty-one patients with acute pulmonary edema plus ex vivo human lungs. Interventions. Measurements of catecholamine levels in patient samples and controlled laboratory studies of the effects of these catecholamine levels on the rates of alveolar fluid clearance in ex vivo human lungs. Measurements and Main Results. The concentrations of both epinephrine and norepinephrine in the pulmonary edema fluid and plasma were similar to 10(-9) M (range of 1-8 x 10(-9) M) in hydrostatic pulmonary edema (n = 6) and acute lung injury patients (n = 15). We therefore tested whether 10(-9) M epinephrine or norepinephrine stimulated alveolar fluid clearance in isolated human lungs and found that these epinephrine or norepinephrine concentrations did not stimulate alveolar fluid clearance. However, higher concentrations of epinephrine (10(-7) M), but not norepinephrine (10(-7) M), significantly stimulated alveolar fluid clearance by 84% above control. Glibenclamide (10(-5) M) and CFTR(inh)-172 (10(-5) M), cystic fibrosis transmembrane conductance regulator inhibitors, completely inhibited the epinephrine-induced stimulation of alveolar fluid clearance. Conclusions. These results indicate that endogenous catecholamine concentrations in pulmonary edema fluid are probably not sufficient to stimulate alveolar fluid clearance. In contrast, administration of exogenous catecholamines into the distal airspaces can stimulate alveolar fluid clearance in the human lung, an effect that is mediated in part by cystic fibrosis transmembrane conductance regulator. Therefore, exogenous cyclic adenosine monophosphate-dependent stimulation will probably be required to accelerate the resolution of alveolar edema in the lungs of patients with pulmonary edema.
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<a href="http://doi.org/10.1097/01.ccm.0000201403.70636.0f" target="_blank" rel="noreferrer noopener">10.1097/01.ccm.0000201403.70636.0f</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2006
activation
alveolar epithelium
catecholamine
Cells
cftr
Critical care medicine
cystic fibrosis transmembrane conductance regulator
Folkesson G
General & Internal Medicine
glibenclamide
Gu X
Injury
Journal Article
liquid clearance
Maeda S
Matthay M A
na+ transport
Norepinephrine
Osanai K
pulmonary edema
rat
resected human lung
resolution
Sagawa M
Sakuma T
Sugita M
Toga H
Wang Z
Ware L B
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.00523.2007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00523.2007</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
L399-L400
Issue
3
Volume
294
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Variations In Enac Subunit Composition May Determine Amiloride Sensitivity And Beta-adrenergic Stimulation Of Lung Fluid Absorption
Publisher
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American Journal of Physiology-Lung Cellular and Molecular Physiology
Date
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2008
2008-03
Subject
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airway epithelia; alveolar; cftr; channels; clearance; mice; Physiology; pulmonary edema; resolution; Respiratory System; sodium; transport
Creator
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Folkesson H G
Identifier
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<a href="http://doi.org/10.1152/ajplung.00523.2007" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00523.2007</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2008
airway epithelia
alveolar
American Journal of Physiology-Lung Cellular and Molecular Physiology
cftr
channels
clearance
Folkesson H G
Mice
Physiology
pulmonary edema
resolution
Respiratory System
Sodium
transport