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Text
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<a href="http://doi.org/10.1002/(sici)1098-2396(19990315)31:4%3C250::aid-syn2%3E3.3.co;2-q" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(sici)1098-2396(19990315)31:4%3C250::aid-syn2%3E3.3.co;2-q</a>
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Pages
250-255
Issue
4
Volume
31
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Title
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Castration differentially alters H-3 nisoxetine binding to norepinephrine uptake sites in olfactory bulb and frontal cortex of male rats
Publisher
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Synapse
Date
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1999
1999-03
Subject
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androgens; cerebral-cortex; chemical cues; conspecific odors; depression; dopamine; h-3 nisoxetine; hormone-releasing hormone; induced plasticity; locus-coeruleus; memory/recognition; Neurosciences & Neurology; norepinephrine transporter; olfaction; transporter; transporter messenger-rna; tyrosine-hydroxylase
Creator
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Shang Y L; Boja J W; Dluzen D E
Description
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In the present study, [H-3]nisoxetine binding to norepinephrine (NE) uptake sites and [H-3]norepinephrine uptake were investigated within olfactory bulb (OB) and frontal cortex homogenates from intact and castrated male rats. Statistically significant reductions in the number of [H-3] nisoxetine binding sites (B-max) were found in OB from the castrates, while significantly increased B-max values were obtained in the frontal cortex. Castration also significantly altered the affinity (K-d) of [H-3]nisoxetine binding in the frontal cortex, but not in the OB. Assessment of [H-3]norepinephrine uptake showed that in neither brain regions were there any statistically significant differences in K-m nor V-max between the castrated and intact male rats, indicating that the basal uptake process is not changed following castration in either of these brain areas. These results demonstrate the differential effects of castration upon [H-3]nisoxetine binding sites between the OB and frontal cortex. Such findings provide new evidence for one of the mechanisms by which androgens may modulate central noradrenergic activity. Synapse 31:250-255, 1999. (C) 1999 Wiley-Liss, Inc.
Identifier
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<a href="http://doi.org/10.1002/(sici)1098-2396(19990315)31:4%3C250::aid-syn2%3E3.3.co;2-q" target="_blank" rel="noreferrer noopener">10.1002/(sici)1098-2396(19990315)31:4%3C250::aid-syn2%3E3.3.co;2-q</a>
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Journal Article
1999
androgens
Boja J W
cerebral-cortex
chemical cues
conspecific odors
Depression
Dluzen D E
Dopamine
h-3 nisoxetine
hormone-releasing hormone
induced plasticity
Journal Article
locus-coeruleus
memory/recognition
Neurosciences & Neurology
norepinephrine transporter
olfaction
Shang Y L
synapse
transporter
transporter messenger-rna
tyrosine-hydroxylase