Phentermine plus fenfluramine produce cocaine-like discriminative cues
analogs; cocaine; combinations; drug discrimination; fenfluramine; Pharmacology & Pharmacy; phentermine; receptors; Research & Experimental Medicine; serotonin; stimulus properties
Drug discrimination studies were conducted in six male Sprague-Dawley rats trained to discriminate the interoceptive cues produced by 10 mg/kg cocaine in an effort to investigate if there is stimulus generalization to phentermine or phentermine + fenfluramine. Once having reached criterion performance, these rats were tested with lower doses of cocaine and generated a typical dose-response curve allowing for calculation of an ED(50) value: 2.798 mg/kg. Testing of phentermine in doses of 1.25-5.0 mg/kg indicated generalization with the highest dose producing 80% cocaine-appropriate responding and allowing for an ED(50) value of 2.356 mg/kg. When the phentermine doses were tested in combination 2.0 mg/kg fenfluramine, however, there was an increase in the discriminability of the highest phentermine dose and a slight decrease in the ED(50) value of the combination. Thus, administration of phentermine + fenfluramine, having both dopamine-releasing and serotonin-releasing properties, respectively, may mimic the neurochemical activity by which cocaine acts in the central nervous system and may possibly allow for cocaine-like effects as these two drugs see increased use in obesity control.
Schechter M D; McBurney D
Life Sciences
1996
1996-10
Journal Article
<a href="http://doi.org/10.1016/s0024-3205(96)00513-9" target="_blank" rel="noreferrer noopener">10.1016/s0024-3205(96)00513-9</a>
Cancer Cell Necrosis By Autoschizis: Synergism Of Antitumor Activity Of Vitamin C : Vitamin K-3 On Human Bladder Carcinoma T24 Cells
apoptosis; bladder; cancer; combinations; cultured-mammalian-cells; cytoskeleton; death; features; induced oxidative stress; Instruments & Instrumentation; mechanism; Microscopy; necrosis; potentiation; tumor; ultrastructure; vitamins
Gilloteaux J; Jamison J M; Arnold D; Ervin E; Eckroat L; Docherty J J; Neal D; Summers J L
Scanning
1998
1998-11
Journal Article or Conference Abstract Publication
n/a
Autoschizis: A New Form Of Cell Death For Human Ovarian Carcinoma Cells Following Ascorbate : Menadione Treatment Nuclear And Dna Degradation
Anatomy & Morphology; ascorbate; cell; Cell Biology; combinations; combined vitamin-c; cultured-mammalian-cells; death; deoxyribonucleic-acid; DNA; growth-invitro; induced oxidative stress; k-3; menadione; Microscopy; nucleus; ovarian carcinoma; scanning electron; sodium ascorbate; synergistic antitumor-activity; ultrastructural aspects
Gilloteaux J; Jamison J M; Lorimer H E; Jarjoura D; Taper H S; Calderon P B; Neal D R; Summers J L
Tissue & Cell
2004
2004-06
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/j.tice.2004.01.006" target="_blank" rel="noreferrer noopener">10.1016/j.tice.2004.01.006</a>