1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0306-4522(95)00221-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0306-4522(95)00221-4</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
321-330
Issue
1
Volume
69
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Reduction In The Number Of Spinal Motor-neurons In Neurotrophin-3-deficient Mice
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-11
Subject
The topic of the resource
bdnf; cell-death; cord; expression; fusimotor neurons; motoneurons; motor neurons; muscle spindles; nerve; Neurosciences & Neurology; neurotrophic factor; neurotrophins; proprioception; rat muscle-spindles; size; survival
Creator
An entity primarily responsible for making the resource
Kucera J; Ernfors P; Walro J; Jaenisch R
Description
An account of the resource
The effects of a deficiency of neurotrophin-3 on spinal motor neurons were assessed by determining the number of myelinated nerve fibers in lumbar ventral spinal roots of mice with a deletion in the neurotrophin-3 gene. Few or no small-caliber (fusimotor) nerve fibers were present in the L4 ventral root of homozygous mutant mice lacking both copies of the neurotrophin-3 gene, and approximately one-half of the normal complement of the fibers was present in heterozygous mice having one copy of the neurotrophin-3 gene relative to wild type mice at two weeks of age. Numbers of fusimotor nerve fibers paralleled numbers of muscle spindles, the target organs of fusimotor innervation, in hindlimb muscles. Muscle spindles and intrafusal fibers were absent in the soleus muscles of homozygous mutants, and were reduced by approximately 50% in heterozygous relative to wild type mice in accord with previous reports. Neurotrophin-3 might be generated by the intrafusal fibers and may provide a target-derived neurotrophic support for developing fusimotor neurons because in the absence of muscle spindles the neurons did not differentiate and/or survive. In contrast, a great majority of skeletomotor neurons that innervate extrafusal muscle fibers differentiated normally in the absence of neurotrophin-3. This study, analysed in conjunction with our previously reported data, suggests that neurotrophin-3 acts in a coordinated fashion to support, either directly or indirectly, the development of each of the three classes of cells-Ia and Ib sensory neurons, fusimotor neurons, and intrafusal muscle fibers-that comprise the limb proprioceptive system.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0306-4522(95)00221-4" target="_blank" rel="noreferrer noopener">10.1016/0306-4522(95)00221-4</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1995
BDNF
cell-death
cord
Ernfors P
expression
fusimotor neurons
Jaenisch R
Journal Article or Conference Abstract Publication
Kucera J
motoneurons
motor neurons
muscle spindles
nerve
Neuroscience
Neurosciences & Neurology
neurotrophic factor
neurotrophins
proprioception
rat muscle-spindles
size
Survival
Walro J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(91)90101-u" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(91)90101-u</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
167-172
Issue
2
Volume
194
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Local Monoaminergic Dependency Of Spinal Ketamine
Publisher
An entity responsible for making the resource available
European Journal of Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-03
Subject
The topic of the resource
(intrathecal); 5-ht (5-hydroxytryptamine; analgesia; antinociception; cord; inhibition; ketamine; neurons; norepinephrine; opiate; opioid receptors; optical isomers; pharmacology; Pharmacology & Pharmacy; rat-brain; receptor; serotonin; tail-flick test
Creator
An entity primarily responsible for making the resource
Crisp T; Perrotti J M; Smith D L; Stafinsky J L; Smith D J
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(91)90101-u" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(91)90101-u</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
(intrathecal)
1991
5-ht (5-hydroxytryptamine
analgesia
antinociception
cord
Crisp T
European journal of pharmacology
inhibition
Ketamine
Neurons
Norepinephrine
opiate
opioid receptors
optical isomers
Perrotti J M
pharmacology
Pharmacology & Pharmacy
rat-brain
Receptor
serotonin
Smith D J
Smith D L
Stafinsky J L
tail-flick test
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(91)90576-f" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(91)90576-f</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
229-232
Issue
2
Volume
133
Search for Full-text
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Title
A name given to the resource
EVALUATION OF THE INTERACTIONS OF SEROTONERGIC AND ADRENERGIC-DRUGS WITH MU, DELTA, AND KAPPA OPIOID BINDING-SITES
Publisher
An entity responsible for making the resource available
Neuroscience Letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-12
Subject
The topic of the resource
receptor; Neurosciences & Neurology; involvement; rat-brain; morphine; dorsal horn; adrenergic; cord; mu opioid; nociceptive; periaqueductal gray; phentolamine; raphe magnus stimulation; reflexes; serotonergic; spinal antinociceptive action; spiroxatrine; delta opioid; kappa opioid
Creator
An entity primarily responsible for making the resource
Monroe P J; Perschke S E; Crisp T; Smith D J
Description
An account of the resource
Several serotonergic and adrenergic agents were tested for an ability to interact with mu, delta, and kappa opioid binding sites. Spiroxatrine interacted nearly equipotently with all three opioid subtypes, yielding K(i) values near 110 nM. A number of other serotonergic and adrenergic agents interacted with affinities in the 1-50-mu-M range. Most of the other compounds tested in this study were found to compete for opioid binding to some degree, though not achieving a 50% inhibition of binding at concentrations up to 100-mu-M. If this interaction between monoaminergic agents and opioid receptors is found to have functional significance, it must be considered in the interpretation of results from studies using these agents to evaluate the contribution of monoaminergic systems to opioid-mediated events.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(91)90576-f" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(91)90576-f</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1991
Adrenergic
cord
Crisp T
delta opioid
dorsal horn
involvement
Journal Article or Conference Abstract Publication
kappa opioid
Monroe P J
MORPHINE
mu opioid
Neuroscience letters
Neurosciences & Neurology
nociceptive
periaqueductal gray
Perschke S E
phentolamine
raphe magnus stimulation
rat-brain
Receptor
reflexes
serotonergic
Smith D J
spinal antinociceptive action
spiroxatrine