1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/sj.bmt.1700797" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/sj.bmt.1700797</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1061-1064
Issue
11
Volume
19
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Toxicity Associated With High-dose Cytosine Arabinoside And Total Body Irradiation As Conditioning For Allogeneic Bone Marrow Transplantation
Publisher
An entity responsible for making the resource available
Bone Marrow Transplantation
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-06
Subject
The topic of the resource
acute lymphoblastic-leukemia; adults; allogeneic; Biophysics; children; cyclophosphamide; cytosine; hematologic; Hematology; Immunology; lymphoma; malignancies; Oncology; preparative regimen; remission; survival; therapy; total body irradiation; toxicity; transplantation; transplantation
Creator
An entity primarily responsible for making the resource
Kumar M; Saleh A; Rao P V; Ochoa S; Meyers L; Miller A; GrahamPole J
Description
An account of the resource
Seventy-three patients with hematological cancers undergoing allogeneic bone marrow transplantation (BMT) were evaluated for event-free survival (EFS) and toxicity, All received 36 g/m(2) cytosine arabinoside (HDA) and 1200 cGy fractionated total body irradiation (TBI). We assessed the association of EFS and toxicities with the following risk factors: age, gender, diagnosis, initial relapse risk and patient-donor histocompatibility. The EFS probability is 33% at 800 days post-BMT, Twenty-six patients (36%) died of toxicity within 100 days and 14 (19%) have relapsed, EFS was inversely associated with age (P < 0.0001) and initial relapse risk (P = 0.007), The risk of pulmonary (P = 0.023) and hepatic toxicity (P = 0.011) increased with age, Diagnosis other than acute lymphoblastic leukemia (ALL) was a risk factor (P = 0.015) for graft-versushost disease (GVHD); and fewer ALL patients died from toxicity (P = 0.014), The probability of sepsis within 100 days post-BMT correlated (P = 0.007) with initial relapse risk. We conclude: (1) the lower EFS and greater pulmonary and hepatic toxicity associated with increasing age indicate a need for less toxic regimens that maintain high antileukemic efficacy for older patients; (2) the high GVHD and sepsis rates seen in certain categories of patients indicate a need for careful definition of eligibility criteria for this still highly toxic treatment.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/sj.bmt.1700797" target="_blank" rel="noreferrer noopener">10.1038/sj.bmt.1700797</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1997
acute lymphoblastic-leukemia
adults
allogeneic
Biophysics
Bone Marrow Transplantation
Children
cyclophosphamide
cytosine
GrahamPole J
hematologic
Hematology
Immunology
Journal Article or Conference Abstract Publication
Kumar M
Lymphoma
malignancies
Meyers L
Miller A
Ochoa S
oncology
preparative regimen
Rao P V
Remission
Saleh A
Survival
therapy
total body irradiation
toxicity
Transplantation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0090-8258(03)00145-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0090-8258(03)00145-8</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
532-535
Issue
3
Volume
89
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A case of chronic paclitaxel administration in ovarian cancer
Publisher
An entity responsible for making the resource available
Gynecologic Oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-06
Subject
The topic of the resource
carcinoma; chronic therapy; cisplatin; cycles; cyclophosphamide; follow-up; free survival; gynecologic malignancies; Obstetrics & Gynecology; Oncology; ovarian-cancer; paclitaxel; phase-ii trial; platinum-based chemotherapy; single-agent paclitaxel
Creator
An entity primarily responsible for making the resource
Von Gruenigen V E; Karlen J R; Waggoner S E
Description
An account of the resource
Background. Treatment with chemotherapeutic agents, after initial ovarian tumor debulking, and during recurrence, results in extended chemotherapy. When ovarian cancer recurs, chemotherapy is continued when patients respond to therapy. However, the disease may become stable. Stable disease is clinically relevant and no longer an indication of treatment failure. Case. A woman with advanced ovarian cancer was treated with cytoxan and cisplatin chemotherapy after having surgical cytoreduction. She progressed and was placed on monthly intravenous paclitaxel. After an initial partial response to therapy, she then went into a prolonged stable course of her disease. She subsequently received 67 cycles of monthly paclitaxel therapy. Conclusion. Chronic administration of paclitaxel resulted in prolonged stabilization of disease and was well tolerated. (C) 2003 Elsevier Science (USA). All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0090-8258(03)00145-8" target="_blank" rel="noreferrer noopener">10.1016/s0090-8258(03)00145-8</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2003
Carcinoma
chronic therapy
cisplatin
cycles
cyclophosphamide
Follow-up
free survival
gynecologic malignancies
Gynecologic oncology
Journal Article
Karlen J R
Obstetrics & Gynecology
oncology
ovarian-cancer
paclitaxel
phase-ii trial
platinum-based chemotherapy
single-agent paclitaxel
von Gruenigen V E
Waggoner S E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00467-008-1005-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00467-008-1005-9</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
301-308
Issue
2
Volume
24
Search for Full-text
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Membranous glomerulonephritis: treatment response and outcome in children
Publisher
An entity responsible for making the resource available
Pediatric Nephrology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-02
Subject
The topic of the resource
childhood; chlorambucil; clinical course; cyclophosphamide; cyclophosphamide; glomerular-filtration-rate; glomerulonephropathy; glomerulosclerosis; Membranous; Membranous glomerulonephritis; methylprednisolone; nephropathy; nephrotic; Nephrotic syndrome; Pediatrics; syndrome; systemic lupus erythematosus; Urology & Nephrology
Creator
An entity primarily responsible for making the resource
Valentini R P; Mattoo T K; Kapur G; Imam A
Description
An account of the resource
The aim of this study was to characterize clinical features, treatment response, and outcome of idiopathic membranous glomerulonephritis (MGN) in a single-center cohort of children. A retrospective review of biopsy-proven idiopathic MGN in 12 children (mean age 11.9 years) was undertaken. Presentation was nephrotic syndrome (NS) (75%), hematuria/proteinuria (17%), and asymptomatic proteinuria (8%). Ten patients (83%) with NS and nephrotic range proteinuria (NRP) were treated with prednisone, and two patients with non-NRP were not treated with immunosuppressive medications. Steroid response in the treated patients was complete (10%), partial (40%), and absent (50%), respectively. Oral cyclophosphamide was used in seven patients of whom five were steroid resistant, one was steroid dependent, and one was partially responsive. At the mean follow up of 27 months, outcome parameters included an estimated glomerular filtration rate of 128 cc/min per 1.73 m(2), albumin of 4.2 gm/dL, and a urine protein/creatinine ratio of 0.87 [median 0.16 (range 0.02-6.52)]. Remission was complete in 75% of the patients and partial in 17%. One patient (8%) with chronic kidney disease (stage 2) was unresponsive to therapy. Complete remission was significantly associated with the absence of chronic histological changes (p=0.03). In conclusion, children with NS and/or NRP associated with MGN appear to have a good prognosis when treated with a combination of corticosteroids and cyclophosphamide.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00467-008-1005-9" target="_blank" rel="noreferrer noopener">10.1007/s00467-008-1005-9</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2009
childhood
chlorambucil
clinical course
cyclophosphamide
glomerular-filtration-rate
glomerulonephropathy
glomerulosclerosis
Imam A
Journal Article
Kapur G
Mattoo T K
Membranous
Membranous glomerulonephritis
methylprednisolone
nephropathy
nephrotic
Nephrotic syndrome
pediatric nephrology
Pediatrics
Syndrome
systemic lupus erythematosus
Urology & Nephrology
Valentini R P