1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1038/sj.bmt.1700797" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/sj.bmt.1700797</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 1061-1064 Issue 11 Volume 19 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Toxicity Associated With High-dose Cytosine Arabinoside And Total Body Irradiation As Conditioning For Allogeneic Bone Marrow Transplantation Publisher An entity responsible for making the resource available Bone Marrow Transplantation Date A point or period of time associated with an event in the lifecycle of the resource 1997 1997-06 Subject The topic of the resource acute lymphoblastic-leukemia; adults; allogeneic; Biophysics; children; cyclophosphamide; cytosine; hematologic; Hematology; Immunology; lymphoma; malignancies; Oncology; preparative regimen; remission; survival; therapy; total body irradiation; toxicity; transplantation; transplantation Creator An entity primarily responsible for making the resource Kumar M; Saleh A; Rao P V; Ochoa S; Meyers L; Miller A; GrahamPole J Description An account of the resource Seventy-three patients with hematological cancers undergoing allogeneic bone marrow transplantation (BMT) were evaluated for event-free survival (EFS) and toxicity, All received 36 g/m(2) cytosine arabinoside (HDA) and 1200 cGy fractionated total body irradiation (TBI). We assessed the association of EFS and toxicities with the following risk factors: age, gender, diagnosis, initial relapse risk and patient-donor histocompatibility. The EFS probability is 33% at 800 days post-BMT, Twenty-six patients (36%) died of toxicity within 100 days and 14 (19%) have relapsed, EFS was inversely associated with age (P < 0.0001) and initial relapse risk (P = 0.007), The risk of pulmonary (P = 0.023) and hepatic toxicity (P = 0.011) increased with age, Diagnosis other than acute lymphoblastic leukemia (ALL) was a risk factor (P = 0.015) for graft-versushost disease (GVHD); and fewer ALL patients died from toxicity (P = 0.014), The probability of sepsis within 100 days post-BMT correlated (P = 0.007) with initial relapse risk. We conclude: (1) the lower EFS and greater pulmonary and hepatic toxicity associated with increasing age indicate a need for less toxic regimens that maintain high antileukemic efficacy for older patients; (2) the high GVHD and sepsis rates seen in certain categories of patients indicate a need for careful definition of eligibility criteria for this still highly toxic treatment. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1038/sj.bmt.1700797" target="_blank" rel="noreferrer noopener">10.1038/sj.bmt.1700797</a> Format The file format, physical medium, or dimensions of the resource Journal Article or Conference Abstract Publication 1997 acute lymphoblastic-leukemia adults allogeneic Biophysics Bone Marrow Transplantation Children cyclophosphamide cytosine GrahamPole J hematologic Hematology Immunology Journal Article or Conference Abstract Publication Kumar M Lymphoma malignancies Meyers L Miller A Ochoa S oncology preparative regimen Rao P V Remission Saleh A Survival therapy total body irradiation toxicity Transplantation