1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1007/s40263-014-0145-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s40263-014-0145-7</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 195-203 Issue 3 Volume 28 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Prospects for the Pharmacological Prevention of Post-Traumatic Stress in Vulnerable Individuals Publisher An entity responsible for making the resource available Cns Drugs Date A point or period of time associated with an event in the lifecycle of the resource 2014 2014-03 Subject The topic of the resource civilian trauma victims; conditioned fear; controlled trial; cortisol-levels; declarative memory; glucocorticoid-induced impairment; motor-vehicle accident; national comorbidity survey; Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry; ptsd symptoms; quality-of-life; randomized Creator An entity primarily responsible for making the resource Ostrowski S A; Delahanty D L Description An account of the resource Biological studies of posttraumatic stress disorder (PTSD) have found alterations of physiological stress pathways [sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis] soon after trauma in individuals who have subsequently developed PTSD, leading researchers to hypothesize that pharmacological manipulation of stress hormone levels may aid in preventing the development of post-traumatic distress. The present paper first reviews the current understanding of the neurobiology of PTSD development and then provides the rationale and evidence for early pharmacological strategies to prevent/reduce post-traumatic distress in at-risk trauma victims. Emphasis is placed on those interventions targeting the SNS and the HPA axis. Furthermore, in light of recent calls to move away from categorical diagnostic outcomes, we discuss how examining post-traumatic distress from a transdiagnostic viewpoint may inform novel chemoprophylactic approaches (intervening pharmacologically after trauma to prevent post-traumatic distress). Current evidence is suggestive for medications, such as propranolol, hydrocortisone, morphine, and oxytocin, impacting early stress hormone levels and subsequent risk for post-traumatic distress; however, future research is needed prior to adapting recommendations for widespread use of any chemoprophylactic treatments. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1007/s40263-014-0145-7" target="_blank" rel="noreferrer noopener">10.1007/s40263-014-0145-7</a> Format The file format, physical medium, or dimensions of the resource Journal Article 2014 civilian trauma victims CNS drugs conditioned fear controlled trial cortisol-levels declarative memory Delahanty D L glucocorticoid-induced impairment Journal Article motor-vehicle accident national comorbidity survey Neurosciences & Neurology Ostrowski S A Pharmacology & Pharmacy Psychiatry PTSD symptoms quality-of-life randomized