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Text
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URL Address
<a href="http://doi.org/10.1016/0304-3940(91)90576-f" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(91)90576-f</a>
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Pages
229-232
Issue
2
Volume
133
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Title
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EVALUATION OF THE INTERACTIONS OF SEROTONERGIC AND ADRENERGIC-DRUGS WITH MU, DELTA, AND KAPPA OPIOID BINDING-SITES
Publisher
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Neuroscience Letters
Date
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1991
1991-12
Subject
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receptor; Neurosciences & Neurology; involvement; rat-brain; morphine; dorsal horn; adrenergic; cord; mu opioid; nociceptive; periaqueductal gray; phentolamine; raphe magnus stimulation; reflexes; serotonergic; spinal antinociceptive action; spiroxatrine; delta opioid; kappa opioid
Creator
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Monroe P J; Perschke S E; Crisp T; Smith D J
Description
An account of the resource
Several serotonergic and adrenergic agents were tested for an ability to interact with mu, delta, and kappa opioid binding sites. Spiroxatrine interacted nearly equipotently with all three opioid subtypes, yielding K(i) values near 110 nM. A number of other serotonergic and adrenergic agents interacted with affinities in the 1-50-mu-M range. Most of the other compounds tested in this study were found to compete for opioid binding to some degree, though not achieving a 50% inhibition of binding at concentrations up to 100-mu-M. If this interaction between monoaminergic agents and opioid receptors is found to have functional significance, it must be considered in the interpretation of results from studies using these agents to evaluate the contribution of monoaminergic systems to opioid-mediated events.
Identifier
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<a href="http://doi.org/10.1016/0304-3940(91)90576-f" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(91)90576-f</a>
Format
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Journal Article or Conference Abstract Publication
1991
Adrenergic
cord
Crisp T
delta opioid
dorsal horn
involvement
Journal Article or Conference Abstract Publication
kappa opioid
Monroe P J
MORPHINE
mu opioid
Neuroscience letters
Neurosciences & Neurology
nociceptive
periaqueductal gray
Perschke S E
phentolamine
raphe magnus stimulation
rat-brain
Receptor
reflexes
serotonergic
Smith D J
spinal antinociceptive action
spiroxatrine