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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.freeradbiomed.2009.06.017" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.freeradbiomed.2009.06.017</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
767-778
Issue
6
Volume
47
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Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress
Publisher
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Free Radical Biology and Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-09
Subject
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Aldehyde dehydrogenase; Biochemistry & Molecular Biology; differential expression; dismutase; Endocrinology & Metabolism; Fasting; fatty-acid oxidation; glutathione-s-transferase; hepatic steatosis; Lipid peroxidation; Lipid peroxidation; liver; manganese-superoxide-dismutase; mitochondrial aldehyde dehydrogenase; nitric-oxide; Null mice; oxidative stress; PPAR-alpha; PPAR-alpha; Protein nitration; Protein oxidation; rat-liver; Steatosis; Superoxide
Creator
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Abdelmegeed M A; Moon K H; Hardwick J P; Gonzalez F J; Song B J
Description
An account of the resource
The peroxisome proliferator-activated receptor-alpha (PPAR alpha) regulates lipid homeostasis, particularly in the liver. This study was aimed at elucidating the relationship between hepatosteatosis and oxidative stress during fasting. Fasted Ppara-null mice exhibited marked hepatosteatosis, which was associated with elevated levels of lipid peroxidation, nitric oxide synthase activity, and hydrogen peroxide accumulation. Total glutathione (GSH), mitochondrial GSH, and the activities of major antioxidant enzymes were also lower in the fasted Ppara-null mice. Consequently, the number and extent of nitrated proteins were markedly increased in the fasted Ppara-null mice, although high levels of protein nitration were still detected in the fed Ppara-null mice while many oxidatively modified proteins were only found in the fasted Ppara-null mice. However, the role of inflammation in increased oxidative stress in the fasted Ppara-null mice was minimal based on the similar levels of tumor necrosis factor-alpha change in all groups. These results with increased oxidative stress observed in the fasted Ppara-null mice compared with other groups demonstrate a role for PPAR alpha in fasting-mediated oxidative stress and that inhibition of PPAR alpha functions may increase the susceptibility to oxidative damage in the presence of another toxic agent. Published by Elsevier Inc.
Identifier
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<a href="http://doi.org/10.1016/j.freeradbiomed.2009.06.017" target="_blank" rel="noreferrer noopener">10.1016/j.freeradbiomed.2009.06.017</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2009
Abdelmegeed M A
Aldehyde Dehydrogenase
Biochemistry & Molecular Biology
differential expression
dismutase
Endocrinology & Metabolism
Fasting
fatty-acid oxidation
Free Radical Biology and Medicine
glutathione-s-transferase
Gonzalez F J
Hardwick J P
hepatic steatosis
Journal Article or Conference Abstract Publication
Lipid Peroxidation
Liver
manganese-superoxide-dismutase
mitochondrial aldehyde dehydrogenase
Moon K H
nitric-oxide
Null mice
Oxidative Stress
PPAR-alpha
Protein nitration
Protein oxidation
rat-liver
Song B J
Steatosis
superoxide
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1210/en.2002-220628" target="_blank" rel="noreferrer noopener">http://doi.org/10.1210/en.2002-220628</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
4764-4774
Issue
12
Volume
143
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Evidence For A Potential Role Of Estrogen In The Penis: Detection Of Estrogen Receptor-alpha And -beta Messenger Ribonucleic Acid And Protein
Publisher
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Endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-12
Subject
The topic of the resource
androgen receptor; differential expression; dorsal-root ganglion; Endocrinology & Metabolism; hyena crocuta-crocuta; in-situ hybridization; male reproductive-system; molecular-cloning; rat pituitary; sexual-behavior; spinal-cord
Creator
An entity primarily responsible for making the resource
Jesmin S; Mowa C N; Matsuda N; Salah-Eldin A E; Togashi H; Sakuma I; Hattori Y; Kitabatake A
Description
An account of the resource
Body tissues are traditionally classified as estrogen targets based on both the response to the hormone and the presence of estrogen receptors (ERs). We undertook the study on expression of ERalpha and ERbeta in the penis to identify compartments/cells responsive to estrogen, using immunohistochemistry, Western blotting, in situ hybridization, and RT-PCR analyses. Expressions of ERalpha and ERbeta in the rat penis were age dependent at both mRNA and protein levels, with the most intense signals being observed during the perinatal period and declining thereafter with age. Initial signals (fetal d 17) of ERalpha were localized to the mesenchyme and subepithelial stroma and later (postnatal d 2) to the corpus spongiosus, corpus cavernosus; and urethral epithelia. ERbeta was initially detected by postnatal d 2 and was localized diffusely in corpus spongiosus and cavernosus in immature rats. In the. adult, both ERs were concentrated largely to the urethral eithelia and vascular and neuronal structures. The present study provides the first evidence for ER expression in the penis. Thus, our data add the penis to the list of estrogen-responsive tissues in males and provide a base and insight for future studies aimed at investigating a functional role of estrogen in the penis, especially in development.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1210/en.2002-220628" target="_blank" rel="noreferrer noopener">10.1210/en.2002-220628</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2002
androgen receptor
differential expression
dorsal-root ganglion
Endocrinology
Endocrinology & Metabolism
Hattori Y
hyena crocuta-crocuta
in-situ hybridization
Jesmin S
Journal Article or Conference Abstract Publication
Kitabatake A
male reproductive-system
Matsuda N
molecular-cloning
Mowa C N
rat pituitary
Sakuma I
Salah-Eldin A E
sexual-behavior
spinal-cord
Togashi H