1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.00205.2003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00205.2003</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
L679-L689
Issue
4
Volume
286
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mechanisms Of Alveolar Protein Clearance In The Intact Lung
Publisher
An entity responsible for making the resource available
American Journal of Physiology-Lung Cellular and Molecular Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-04
Subject
The topic of the resource
acute respiratory distress syndrome; air-blood barrier; apoprotein sp-a; bronchoalveolar lavage fluid; diffusion; endocytosis; epithelial-cell monolayers; ii cells; instillation; intratracheal; junctions; opens tight; perfused rabbit lungs; Physiology; protein; rat lung; Respiratory System; respiratory-distress syndrome; transport pulmonary edema
Creator
An entity primarily responsible for making the resource
Hastings R H; Folkesson H G; Matthay M A
Description
An account of the resource
Transport of protein across the alveolar epithelial barrier is a critical process in recovery from pulmonary edema and is also important in maintaining the alveolar milieu in the normal healthy lung. Various mechanisms have been proposed for clearing alveolar protein, including transport by the mucociliary escalator, intra-alveolar degradation, or phagocytosis by macrophages. However, the most likely processes are endocytosis across the alveolar epithelium, known as transcytosis, or paracellular diffusion through the epithelial barrier. This article focuses on protein transport studies that evaluate these two potential mechanisms in whole lung or animal preparations. When protein concentrations in the air spaces are low, e. g., albumin concentrations <0.5 g/100 ml, protein transport demonstrates saturation kinetics, temperature dependence indicating high energy requirements, and sensitivity to pharmacological agents that affect endocytosis. At higher concentrations, the protein clearance rate is proportional to protein concentration without signs of saturation, inversely related to protein size, and insensitive to endocytosis inhibition. Temperature dependence suggests a passive process. Based on these findings, alveolar albumin clearance occurs by receptor-mediated transcytosis at low protein concentrations but proceeds by passive paracellular mechanisms at higher concentrations. Because protein concentrations in pulmonary edema fluid are high, albumin concentrations of 5 g/100 ml or more, clearance of alveolar protein occurs by paracellular pathways in the setting of pulmonary edema. Transcytosis may be important in regulating the alveolar milieu under nonpathological circumstances. Alveolar degradation may become important in long-term protein clearance, clearance of insoluble proteins, or under pathological conditions such as immune reactions or acute lung injury.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.00205.2003" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00205.2003</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2004
acute respiratory distress syndrome
air-blood barrier
American Journal of Physiology-Lung Cellular and Molecular Physiology
apoprotein sp-a
bronchoalveolar lavage fluid
diffusion
Endocytosis
epithelial-cell monolayers
Folkesson H G
Hastings R H
ii cells
instillation
Intratracheal
Journal Article or Conference Abstract Publication
junctions
Matthay M A
opens tight
perfused rabbit lungs
Physiology
Protein
rat lung
Respiratory System
respiratory-distress syndrome
transport pulmonary edema
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1163/1568555042474112" target="_blank" rel="noreferrer noopener">http://doi.org/10.1163/1568555042474112</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
485-494
Issue
6
Volume
7
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Two Generations Of Synthetic Membranes For Biological/medical Applications
Publisher
An entity responsible for making the resource available
Designed Monomers and Polymers
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004
Subject
The topic of the resource
amphiphilic membranes; amphiphilic networks; biocompatibility; diffusion; domains; Glucose; immunoisolation; insulin diffusion; isobutylene; living carbocationic polymerization; membranes; polyisobutylene; Polymer Science; polymers; selective permeability; tricomponent
Creator
An entity primarily responsible for making the resource
Kennedy J P; Rosenthal K S; Kashibhatla B
Description
An account of the resource
Two generations of amphiphilic membranes synthesized in our laboratories for biologicaUniedical applications are highlighted. Recent results obtained with representative 2nd generation membranes designed specifically for immunoencapsulation of pancreatic islets and cells, are Summarized. The latter tri-component membranes comprise well-defined hydrophilic poly(ethylene glycol) and hydrophobic/oxyphilic polydimethylsiloxane segments crosslinked by oxyphilic polycyclosiloxane domains, which also provide reinforcement. Select membranes are demonstrated to allow the diffusion of glucose and insulin but prevent the permeation of immunoglobulin G. These membranes remain permeable despite long incubation in IgG solution.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1163/1568555042474112" target="_blank" rel="noreferrer noopener">10.1163/1568555042474112</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2004
amphiphilic membranes
amphiphilic networks
Biocompatibility
Designed Monomers and Polymers
diffusion
domains
GLUCOSE
immunoisolation
insulin diffusion
isobutylene
Journal Article or Conference Abstract Publication
Kashibhatla B
Kennedy J P
living carbocationic polymerization
membranes
polyisobutylene
Polymer Science
Polymers
Rosenthal K S
selective permeability
tricomponent
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.cryobiol.2006.10.193" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.cryobiol.2006.10.193</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
36-43
Issue
1
Volume
54
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cryopreservation Of Porcine Articular Cartilage: Mri And Biochemical Results After Different Freezing Protocols
Publisher
An entity responsible for making the resource available
Cryobiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-02
Subject
The topic of the resource
2-step procedure; articular-cartilage; biochemical; cryopreservation; culture cells frozen; diffusion; dimethyl sulfoxide; femoral condyles; fresh; Life Sciences & Biomedicine - Other Topics; magnetic-resonance microscopy; MRI; osteoarticular allografts; osteochondral allograft transplantation; Physiology; porcine; survival; tissue
Creator
An entity primarily responsible for making the resource
Laouar L; Fishbein K; McGann L E; Horton W E; Spencer R G; Jomha N M
Description
An account of the resource
The objective of this study was to investigate the effects of cryopreservation on the components of articular cartilage (AC) matrix by utilizing magnetic resonance imaging (MRI) and biochemical assessments. Porcine AC (10 mm osteochondral dowels) was collected into four groups - (1) phosphate buffered saline (PBS) control, (2) PBS snap frozen in liquid nitrogen, (3) slow-cooled in dimethyl sulfoxide (DMSO), and (4) slow cooled in PBS (in absence of DMSO). MRI results demonstrated three distinct zones in the cartilage. After exposure to ice formation during cryopreservation procedures, alterations in MRI determined matrix fixed charged density and magnetization transfer rate were noted. In addition, biochemical assays demonstrated significant alterations in chondroitin sulfate and hydroxyproline content over time without differences in hydration or DNA content. In conclusion, MRI was able to detect some changes in the intact cartilage matrix structure consistent with biochemical assessments after ice formation during cryopreservation of intact porcine AC. Furthermore, biochemical assessments supported some of these findings and changed significantly after incubating the cartilage matrix for 36-72 h in PBS in terms of chondroitin sulfate and hydroxyproline content. (c) 2006 Elsevier Inc. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.cryobiol.2006.10.193" target="_blank" rel="noreferrer noopener">10.1016/j.cryobiol.2006.10.193</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2-step procedure
2007
articular-cartilage
biochemical
Cryobiology
cryopreservation
culture cells frozen
diffusion
dimethyl sulfoxide
femoral condyles
Fishbein K
fresh
Horton W E
Jomha N M
Journal Article or Conference Abstract Publication
Laouar L
Life Sciences & Biomedicine - Other Topics
magnetic-resonance microscopy
McGann L E
MRI
osteoarticular allografts
osteochondral allograft transplantation
Physiology
porcine
Spencer R G
Survival
tissue
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1359/jbmr.2001.16.6.1092" target="_blank" rel="noreferrer noopener">http://doi.org/10.1359/jbmr.2001.16.6.1092</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1092-1100
Issue
6
Volume
16
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Histomorphometry of the embryonic avian growth plate by proton nuclear magnetic resonance microscopy
Publisher
An entity responsible for making the resource available
Journal of Bone and Mineral Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-06
Subject
The topic of the resource
appearance; articular-cartilage; bone-formation; cartilage; chick; deposits; diffusion; Endocrinology & Metabolism; growth-plate; hyaline cartilage; mineral; morphology; mr-imaging characteristics; nuclear magnetic resonance microscopy; relaxation; sequences
Creator
An entity primarily responsible for making the resource
Potter K; Landis W J; Spencer R G S
Description
An account of the resource
Quantitative nuclear magnetic resonance (NMR) microscopy was used to characterize the biochemical and morphological properties of the different zones within the growth plate of an embryonic chick femur. For precalcified tissue, water proton transverse relaxation times (T-2) and magnetization transfer values (MT) were directly and inversely dependent, respectively, on tissue cellularity, defined as the intracellular area per unit area on histological sections. T-2 values extrapolated for intra- and extracellular water were 96 ms and 46 ms, respectively. The extracellular T-2 was comparable with that measured for mature cartilage. The MT values extrapolated for intra- and extracellular compartments were 0.32 and 0.85, respectively, These values were comparable with those values reported in the literature for cell pellets and for mature cartilage tissue. Thus, cellularity dominated the NMR properties of this immature cartilage tissue. Mineral deposits within calcified cartilage and periosteal bone invoked NMR relaxation processes that were dependent on the inorganic mineral phase; Additionally, collagen molecules present in mineralized zones gave rise to a significant MT effect. These results show the utility of water proton NMR microscopy for assessing both the organic and inorganic ph ases within mineralized tissues.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1359/jbmr.2001.16.6.1092" target="_blank" rel="noreferrer noopener">10.1359/jbmr.2001.16.6.1092</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2001
appearance
articular-cartilage
bone-formation
Cartilage
chick
deposits
diffusion
Endocrinology & Metabolism
growth-plate
hyaline cartilage
Journal Article
Journal of Bone and Mineral Research
Landis W J
mineral
morphology
mr-imaging characteristics
nuclear magnetic resonance microscopy
Potter K
relaxation
sequences
Spencer R G S