1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/j.tips.2005.07.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.tips.2005.07.003</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 470-476 Issue 9 Volume 26 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource AGS proteins: receptor-independent activators of G-protein signaling Publisher An entity responsible for making the resource available Trends in Pharmacological Sciences Date A point or period of time associated with an event in the lifecycle of the resource 2005 2005-09 Subject The topic of the resource Pharmacology & Pharmacy; protein; heterotrimeric g-proteins; C. elegans; accessory proteins; asymmetric cell-division; dissociation inhibitor activity; g-alpha subunits; goloco motif; nucleotide exchange factor; ras-related; regulatory motifs Creator An entity primarily responsible for making the resource Blumer J B; Cismowski M J; Sato M; Lanier S M Description An account of the resource The identification of AGS proteins as receptor-independent activators of G-protein signaling reveals unexpected mechanisms for the regulation of heterotrimeric G-protein activation and has opened up new areas of research related to the role of G proteins as signal transducers. In addition to their obvious interest associated with G-protein-coupled receptor signaling, AGS proteins might provide alternative binding partners for G-protein subunits that enable them to serve unexpected functions related to cell division, differentiation and organelle structure that might operate independently of a GPCR. Thus, these proteins and the concepts advanced with their discovery highlight the diversity associated with G-protein signaling and present new avenues for the development of therapeutics that target G-protein signaling. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.tips.2005.07.003" target="_blank" rel="noreferrer noopener">10.1016/j.tips.2005.07.003</a> Format The file format, physical medium, or dimensions of the resource Journal Article or Conference Abstract Publication 2005 accessory proteins asymmetric cell-division Blumer J B C. elegans Cismowski M J dissociation inhibitor activity g-alpha subunits goloco motif heterotrimeric g-proteins Journal Article or Conference Abstract Publication Lanier S M nucleotide exchange factor Pharmacology & Pharmacy Protein ras-related regulatory motifs Sato M Trends in pharmacological sciences