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Text
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<a href="http://doi.org/10.1016/j.tips.2005.07.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.tips.2005.07.003</a>
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Pages
470-476
Issue
9
Volume
26
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Title
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AGS proteins: receptor-independent activators of G-protein signaling
Publisher
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Trends in Pharmacological Sciences
Date
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2005
2005-09
Subject
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Pharmacology & Pharmacy; protein; heterotrimeric g-proteins; C. elegans; accessory proteins; asymmetric cell-division; dissociation inhibitor activity; g-alpha subunits; goloco motif; nucleotide exchange factor; ras-related; regulatory motifs
Creator
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Blumer J B; Cismowski M J; Sato M; Lanier S M
Description
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The identification of AGS proteins as receptor-independent activators of G-protein signaling reveals unexpected mechanisms for the regulation of heterotrimeric G-protein activation and has opened up new areas of research related to the role of G proteins as signal transducers. In addition to their obvious interest associated with G-protein-coupled receptor signaling, AGS proteins might provide alternative binding partners for G-protein subunits that enable them to serve unexpected functions related to cell division, differentiation and organelle structure that might operate independently of a GPCR. Thus, these proteins and the concepts advanced with their discovery highlight the diversity associated with G-protein signaling and present new avenues for the development of therapeutics that target G-protein signaling.
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<a href="http://doi.org/10.1016/j.tips.2005.07.003" target="_blank" rel="noreferrer noopener">10.1016/j.tips.2005.07.003</a>
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Journal Article or Conference Abstract Publication
2005
accessory proteins
asymmetric cell-division
Blumer J B
C. elegans
Cismowski M J
dissociation inhibitor activity
g-alpha subunits
goloco motif
heterotrimeric g-proteins
Journal Article or Conference Abstract Publication
Lanier S M
nucleotide exchange factor
Pharmacology & Pharmacy
Protein
ras-related
regulatory motifs
Sato M
Trends in pharmacological sciences