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Text
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URL Address
<a href="http://doi.org/10.1084/jem.20191374" target="_blank" rel="noreferrer noopener">http://doi.org/10.1084/jem.20191374</a>
Pages
e20191374
Issue
4
Volume
217
ISSN
0022-1007
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Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Pharmacy; NEOMED College of Graduate Studies
NEOMED Department
Department of Pharmaceutical Sciences
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Title
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Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model
Publisher
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Journal of Experimental Medicine
Date
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2020
2020-04
Subject
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accumulation; distinct; dynamics; fate; macrophages; monocytes; pathology; reveals; system; turnover
Creator
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Reed-Geaghan Erin G; Croxford Andrew L; Becher Burkhard; Landreth Gary E
Description
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Alzheimer's disease (AD) is accompanied by a robust inflammatory response mediated by plaque-associated myeloid cells of the brain. These cells exhibit altered gene expression profiles and serve as a barrier, preventing neuritic dystrophy. The origin of these cells has been controversial and is of therapeutic importance. Here, we genetically labeled different myeloid populations and unequivocally demonstrated that plaque-associated myeloid cells in the AD brain are derived exclusively from resident microglia, with no contribution from circulating peripheral monocytes.
Identifier
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<a href="http://doi.org/10.1084/jem.20191374" target="_blank" rel="noreferrer noopener">10.1084/jem.20191374</a>
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journalArticle
2020
accumulation
Becher Burkhard
Croxford Andrew L
Department of Pharmaceutical Sciences
distinct
dynamics
fate
Journal Article
Journal of Experimental Medicine
journalArticle
June 2020 Update I
Landreth Gary E
Macrophages
monocytes
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Pathology
Reed-Geaghan Erin G
reveals
system
Turnover