1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1152/ajplung.2001.280.4.l606" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.2001.280.4.l606</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages L606-L616 Issue 4 Volume 280 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Alveolar fluid clearance in late-gestational guinea pigs after labor induction: mechanisms and regulation Publisher An entity responsible for making the resource available American Journal of Physiology-Lung Cellular and Molecular Physiology Date A point or period of time associated with an event in the lifecycle of the resource 2001 2001-04 Subject The topic of the resource absorption; adrenaline; alveolar epithelium; beta-adrenergic stimulation; birth; catecholamines; developmental-changes; distress syndrome; epinephrine; fetal sheep; infant respiratory; lung liquid clearance; newborn rabbits; Physiology; prenatal development; Respiratory System; sodium transport; transport; ventilated rats Creator An entity primarily responsible for making the resource Norlin A; Folkesson H G Description An account of the resource We tested the hypothesis that labor-induced epinephrine release would stimulate alveolar fluid clearance in preterm fetuses. Preterm fetuses were obtained by cesarean section from timed-pregnant guinea pigs at 61-69 days postconception. Fetal guinea pigs were euthanized and placed on continuous positive airway pressure oxygenation, and an isosmolar 5% albumin solution was instilled. Alveolar fluid clearance was measured over 1 h. The fetal lung began to absorb fluid at 64-66 days postconception, and at birth, alveolar fluid clearance quadrupled. Baseline alveolar fluid clearance when present was sensitive to propranolol inhibition and depended on beta -adrenergic stimulation. Measurements of plasma epinephrine in fetal animals confirmed high epinephrine levels in 66- to 69-day postconception fetuses. Prenatal alveolar fluid clearance when present was highly amiloride sensitive, suggesting that amiloride-sensitive Na+ channels were critical. Oxytocin-induced labor initiated an amiloride- and propranolol-sensitive net alveolar fluid clearance in 61-day-gestation animals. Moreover, oxytocin induced significant epinephrine release in all fetuses. These results have clinical implications for infants delivered by cesarean section before the onset of labor. Use of pharmacological agents to induce labor may reduce the occurrence and severity of perinatal respiratory distress. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1152/ajplung.2001.280.4.l606" target="_blank" rel="noreferrer noopener">10.1152/ajplung.2001.280.4.l606</a> Format The file format, physical medium, or dimensions of the resource Journal Article 2001 Absorption adrenaline alveolar epithelium American Journal of Physiology-Lung Cellular and Molecular Physiology beta-adrenergic stimulation birth catecholamines developmental-changes distress syndrome Epinephrine fetal sheep Folkesson H G infant respiratory Journal Article lung liquid clearance newborn rabbits Norlin A Physiology prenatal development Respiratory System sodium transport transport ventilated rats