1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(91)90277-w" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(91)90277-w</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
347-353
Issue
3
Volume
202
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
POSSIBLE SEROTONERGIC AND DOPAMINERGIC MEDIATION OF THE N-ETHYL-3,4-METHYLENEDIOXYAMPHETAMINE DISCRIMINATIVE STIMULUS
Publisher
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European Journal of Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-09
Subject
The topic of the resource
rat; 3; 2; Pharmacology & Pharmacy; dopamine; drug discrimination; fenfluramine; serotonin; quipazine; amphetamine; mde; mdma; p-chlorophenylalanine; pigeons; saline; tfmpp; (3; 4-methylenedioxyamphetamine); 4-methylenedioxymethamphetamine); 4-tetrahydro-beta-carboline; 5-ht (5-hydroxytryptamine; 6-methoxy-1; mde (n-ethyl-3
Creator
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Boja J W; Schechter M D
Description
An account of the resource
Eight male rats previously trained to discriminate 2.0 mg/kg N-ethyl-3,4-methylenedioxyamphetamine (MDE) from its vehicle in a two-lever, food motivated task were utilized to characterize the stimulus properties of MDE. The 5-HT receptor agonists 1-(m-trifluoromethylphenyl)piperazine (TFMPP), quipazine and 6-methoxy-1,2,3,4 tetrahydro-beta-carboline were able to generalize to the stimulus produced by MDE. However, the 5-HT receptor agonists m-chlorophenylpiperazine (mCPP), buspirone and norfenfluramine, the dopamine receptor agonist amphetamine, as well as the acetylcholine receptor agonist arecoline did not completely generalize. In addition, the simultaneous administration of norfenfluramine and amphetamine generalized to MDE. Pretreatment with the serotonin receptor antagonists cinanserin and metergoline or the dopamine receptor antagonist haloperidol failed to completely inhibit the discriminative stimulus produced by MDE. Multiple p-chlorophenylalanine (PCPA) pretreatments significantly reduced MDE discrimination, whereas vehicle discrimination was unaffected. Five days following cessation of PCPA pretreatment, MDE discrimination returned to criterion levels and remained at that level. These results suggest that the stimulus produced by MDE involve a complex interaction of various neurotransmitters, with both serotonergic and dopaminergic components.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(91)90277-w" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(91)90277-w</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
(3
1991
2
3
4-methylenedioxyamphetamine)
4-methylenedioxymethamphetamine)
4-tetrahydro-beta-carboline
5-ht (5-hydroxytryptamine
6-methoxy-1
amphetamine
Boja J W
Dopamine
drug discrimination
European journal of pharmacology
fenfluramine
Journal Article or Conference Abstract Publication
mde
mde (n-ethyl-3
mdma
p-chlorophenylalanine
Pharmacology & Pharmacy
pigeons
quipazine
rat
saline
Schechter M D
serotonin
tfmpp
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0024-3205(96)00513-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0024-3205(96)00513-9</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
PL303-PL308
Issue
20
Volume
59
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Dublin Core
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Title
A name given to the resource
Phentermine plus fenfluramine produce cocaine-like discriminative cues
Publisher
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Life Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-10
Subject
The topic of the resource
analogs; cocaine; combinations; drug discrimination; fenfluramine; Pharmacology & Pharmacy; phentermine; receptors; Research & Experimental Medicine; serotonin; stimulus properties
Creator
An entity primarily responsible for making the resource
Schechter M D; McBurney D
Description
An account of the resource
Drug discrimination studies were conducted in six male Sprague-Dawley rats trained to discriminate the interoceptive cues produced by 10 mg/kg cocaine in an effort to investigate if there is stimulus generalization to phentermine or phentermine + fenfluramine. Once having reached criterion performance, these rats were tested with lower doses of cocaine and generated a typical dose-response curve allowing for calculation of an ED(50) value: 2.798 mg/kg. Testing of phentermine in doses of 1.25-5.0 mg/kg indicated generalization with the highest dose producing 80% cocaine-appropriate responding and allowing for an ED(50) value of 2.356 mg/kg. When the phentermine doses were tested in combination 2.0 mg/kg fenfluramine, however, there was an increase in the discriminability of the highest phentermine dose and a slight decrease in the ED(50) value of the combination. Thus, administration of phentermine + fenfluramine, having both dopamine-releasing and serotonin-releasing properties, respectively, may mimic the neurochemical activity by which cocaine acts in the central nervous system and may possibly allow for cocaine-like effects as these two drugs see increased use in obesity control.
Identifier
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<a href="http://doi.org/10.1016/s0024-3205(96)00513-9" target="_blank" rel="noreferrer noopener">10.1016/s0024-3205(96)00513-9</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1996
analogs
Cocaine
combinations
drug discrimination
fenfluramine
Journal Article
Life sciences
McBurney D
Pharmacology & Pharmacy
phentermine
Receptors
Research & Experimental Medicine
Schechter M D
serotonin
stimulus properties
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0306-3623(91)90226-v" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0306-3623(91)90226-v</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
889-893
Issue
5
Volume
22
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
EFFECT OF SEROTONIN DEPLETION BY PARA-CHLOROPHENYLALANINE UPON DISCRIMINATIVE BEHAVIORS
Publisher
An entity responsible for making the resource available
General Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991
Subject
The topic of the resource
amphetamine; cathinone; dopaminergic mediation; drug discrimination; fenfluramine; lsd; pharmacological analysis; Pharmacology & Pharmacy; rat-brain; stimulus properties; yohimbine
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
1. Para-chlorophenylalanine (p-CPA), a competitive inhibitor of the serotonin (5-HT) synthesis enzyme tryptophan hydroxylase, was administered to rats at a dosage (100 mg/kg daily for 3 days) that depletes 5-HT. 2. Different groups of these rats were previously trained to discriminate the interoceptive stimuli produced by amphetamine, cathinone, 3,4-methylenedioxymethamphetamine (MDMA), N-ethyl-3,4-methylenedioxyamphetamine (MDE), fenfluramine or yohimbine, and the effect of p-CPA pretreatment upon their discriminative performance was compared with the effect of saline (control) pretreatment. 3. p-CPA was shown to have no effect upon the dopaminergically-mediated stimuli produced by the stimulants amphetamine and cathinone or upon yohimbine performance. 4. p-CPA significantly decreased discriminative performance with the serotonergic releasing drugs MDMA, MDE and fenfluramine. This decrease in discriminative performance returned to pre-p-CPA (criterion) levels at a time (9-12 days) when 5-HT has been reported to replete to normal brain concentrations. 5. It is concluded that p-CPA pretreatment lowers brain 5-HT and, in turn, significantly decreases the ability of rats to discriminate centrally active drugs whose interoceptive cueing stimuli are mediated by 5-HT neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0306-3623(91)90226-v" target="_blank" rel="noreferrer noopener">10.1016/0306-3623(91)90226-v</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1991
amphetamine
cathinone
dopaminergic mediation
drug discrimination
fenfluramine
General pharmacology
Journal Article
lsd
pharmacological analysis
Pharmacology & Pharmacy
rat-brain
Schechter M D
stimulus properties
yohimbine