1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.drugalcdep.2007.07.019" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.drugalcdep.2007.07.019</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
164-172
Issue
1
Volume
92
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Brain Macrostructural And Microstructural Abnormalities In Cocaine Dependence
Publisher
An entity responsible for making the resource available
Drug and Alcohol Dependence
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-01
Subject
The topic of the resource
abstinent; abuse; addiction; alcohol; brain; chronic cerebral hypoperfusion; cocaine; dependence; diffusion tensor imaging (DTI); drug-abuse; gerbil brain; magnetic resonance imaging (MRI); prefrontal cortex; Psychiatry; schizophrenia; Substance Abuse; users; white-matter integrity
Creator
An entity primarily responsible for making the resource
Lim K O; Wozniak J R; Mueller B A; Franc D T; Specker S M; Rodriguez C P; Silverman A B; Rotrosen J P
Description
An account of the resource
Rationale: Two previous studies have utilized diffusion tensor imaging (DTI) to examine microstructural integrity in cocaine abuse and found 41 evidence of brain abnormalities in white matter. Objective: Using anatomical magnetic resonance imaging (MRI), DTI, and clinical evaluation, the macrostructural and microstructural correlates of cocaine abuse were investigated. Methods: Twenty-one men and women (mean age 42.5 and mean 18.9 years of cocaine use) and 21 age/gender-matched controls were included. Fractional anisotropy (FA) was measured in frontal white matter ROIs. Gray and white matter volumes in superior and inferior frontal regions were compared. Results: DTI data revealed that cocaine users had lower FA than controls, specifically in inferior frontal white matter. FA differences were not seen in other areas. Significant volumetric differences were not seen, but both gray and white matter inferior frontal volumes trended toward smaller in the cocaine group. The data suggested that duration of use was associated with decreased gray and white matter volumes. FA and gray matter volume were correlated in cocaine users. Conclusions: Both macrostructural and microstructural abnormalities were seen in a group of cocaine abusers. Length of cocaine use was associated with severity of the brain abnormalities. Future studies of white matter tissue integrity are warranted including examination of the relationship between DTI measures and traditional volumetric measures. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.drugalcdep.2007.07.019" target="_blank" rel="noreferrer noopener">10.1016/j.drugalcdep.2007.07.019</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2008
abstinent
abuse
Addiction
Alcohol
Brain
chronic cerebral hypoperfusion
Cocaine
dependence
diffusion tensor imaging (DTI)
Drug and Alcohol Dependence
drug-abuse
Franc D T
gerbil brain
Journal Article or Conference Abstract Publication
Lim K O
magnetic resonance imaging (MRI)
Mueller B A
prefrontal cortex
Psychiatry
Rodriguez C P
Rotrosen J P
Schizophrenia
Silverman A B
Specker S M
Substance Abuse
users
white-matter integrity
Wozniak J R