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<a href="http://doi.org/10.1016/0304-3940(92)90200-q" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(92)90200-q</a>
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Pages
47-50
Issue
1
Volume
145
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Title
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Formation Of Muscle-spindles In The Absence Of Motor Innervation
Publisher
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Neuroscience Letters
Date
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1992
1992-09
Subject
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afferent; differentiation; efferent; fibers; intrafusal muscle fiber; muscle; nerve; Neurosciences & Neurology; rat; spindle development
Creator
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Kucera J; Walro J M
Description
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Whether muscle spindles can form in muscles innervated only by afferents was investigated by removing the lumbosacral segment of the spinal cord immediately after crushing the nerve to the medial gastrocnemius (MG) muscle in newborn rats, and administering nerve growth factor for 10 days afterwards. The nerve-crushed MG muscles reinnervated by afferents in the absence of motor innervation were examined at postnatal (P) days 7, 9 and 30 for the presence of spindles by light and electron miscroscope. Reinnervated MG muscles contained spindle-like encapsulations of 1-4 fibers at 7, 9 and 30 days after the nerve crush. The number of spindles exceeded that of normal MG muscles, suggestive of de novo formation of spindles. All nerve-muscle contacts in the spindles had features of sensory endings, and intrafusal fibers expressed the spindle-specific slow-tonic myosin heavy chain (MHC) isoform at P30. No motor endplates were visible on any muscle fibers and extrafusal fibers were atrophied, as would be predicted in the absence of motor innervation. Thus, efferents are not essential for the formation and differentiation of muscle spindles in reinnervated muscles of neonatal rats.
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<a href="http://doi.org/10.1016/0304-3940(92)90200-q" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(92)90200-q</a>
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Journal Article or Conference Abstract Publication
1992
afferent
differentiation
efferent
fibers
intrafusal muscle fiber
Journal Article or Conference Abstract Publication
Kucera J
Muscle
nerve
Neuroscience letters
Neurosciences & Neurology
rat
spindle development
Walro J M