1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
514-520
Issue
4
Volume
41
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Peroxisome Proliferator-activated Receptor Alpha (ppar Alpha) And Agonist Inhibit Cholesterol 7 Alpha-hydroxylase Gene (cyp7a1) Transcription
Publisher
An entity responsible for making the resource available
Journal of Lipid Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-04
Subject
The topic of the resource
bezafibrate; bile acid synthesis; Biochemistry & Molecular Biology; cytochrome P450; drugs; elements; expression; fatty-acids; gallstones; HNF-4; hypolipidemic; hypolipidemic drugs; isoform; lipoprotein metabolism; nuclear receptors; peroxisome proliferators; rat; suppression
Creator
An entity primarily responsible for making the resource
Marrapodi M; Chiang J Y L
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2000
bezafibrate
Bile acid synthesis
Biochemistry & Molecular Biology
Chiang J Y L
cytochrome P450
Drugs
elements
expression
fatty-acids
gallstones
HNF-4
hypolipidemic
hypolipidemic drugs
isoform
Journal of lipid research
lipoprotein metabolism
Marrapodi M
Nuclear Receptors
peroxisome proliferators
rat
suppression
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2192-2200
Issue
11
Volume
39
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Transcriptional activation of the cholesterol 7 alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors
Publisher
An entity responsible for making the resource available
Journal of Lipid Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-11
Subject
The topic of the resource
rat; liver; bile acid synthesis; Biochemistry & Molecular Biology; expression; messenger-rna; elements; metabolism; promoter; nuclear; mutations; cytochrome P450; cholesterol 7; alpha-hydroxylase; bile acid response element; factor coup-tf; gene transcription and regulation; hormone receptor; retinoic acid receptors
Creator
An entity primarily responsible for making the resource
Crestani M; Sadeghpour A; Stroup D; Galli G; Chiang J Y L
Description
An account of the resource
The gene encoding cholesterol 7 alpha-hydroxylase (CYP7A), the rate-limiting enzyme in bile acid synthesis, is transcriptionally regulated by bile acids and hormones. Previously, we have identified two bile acid response elements (BARE) in the promoter of the CYP7A gene, The BARE II is located in nt -149/-118 region and contains three hormone response element (HRE)-like sequences that form two overlapping nuclear receptor binding sites. One is a direct repeat separated by one nucleotide DR1 (-146-TGGACTtAGTTCA-134) and the other is a direct repeat separated by five nucleotides DR5 (-139-AGTTCAaggccGGG TAA-123). Mutagenesis of these HRE sequences resulted in lower transcriptional activity of the CYP7A promoter/reporter genes in transient transfection assay in HepG2 cells. The orphan nuclear receptor, hepatocyte nuclear factor 4 (HNF-4)(1), binds to the DR1 sequence as assessed by electrophoretic mobility shift assay, and activates the CYP7A promoter/reporter activity by about 9-fold. Cotransfection of HNF-4 plasmid with another orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor LI (COUP-TRI), synergistically activated the CYP7A transcription by 80-fold. The DR5 binds the RXR/RAR heterodimer, A hepatocyte nuclear factor-3 (HNF-3) binding site (-175-TGTTTGTTCT-166) was identified. HNF-3 was required for both basal transcriptional activity and stimulation of the rat CYP7A promoter activity by retinoic acid, Combinatorial interactions and binding of these transcription factors to BAREs may modulate the promoter activity and also mediate bile acid repression of CYP7A gene transcription.
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1998
alpha-hydroxylase
bile acid response element
Bile acid synthesis
Biochemistry & Molecular Biology
Chiang J Y L
cholesterol 7
Crestani M
cytochrome P450
elements
expression
factor coup-tf
Galli G
gene transcription and regulation
hormone receptor
Journal Article or Conference Abstract Publication
Journal of lipid research
Liver
messenger-rna
Metabolism
mutations
nuclear
promoter
rat
retinoic acid receptors
Sadeghpour A
Stroup D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/molbev/msi179" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/molbev/msi179</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1823-1833
Issue
9
Volume
22
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A retroposon analysis of Afrotherian phylogeny
Publisher
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Molecular Biology and Evolution
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-09
Subject
The topic of the resource
Afrotheria; base composition; Biochemistry & Molecular Biology; elements; endemic african mammals; evolution; Evolutionary Biology; Genes; Genetics &; Heredity; mammalian phylogeny; mitochondrial genomes; molecular evidence; Paenungulata; placental mammals; retroposons; SINEs; SINEs; support; Tethytheria
Creator
An entity primarily responsible for making the resource
Nishihara H; Satta Y; Nikaido M; Thewissen J G M; Stanhope M J; Okada N
Description
An account of the resource
Recent comprehensive studies of DNA sequences support the monophyly of Afrotheria, comprising elephants, sirenians (dugongs and manatees), hyraxes, tenrecs, golden moles, aardvarks, and elephant shrews, as well as that of Paenungulata, comprising elephants, sirenians, and hyraxes. However, phylogenetic relationships among paenungulates, as well as among nonpaenungulates, have remained ambiguous. Here we applied an extensive retroposon analysis to these problems to support the monophyly of aardvarks, tenrecs, and golden moles, with elephant shrews as their sister group. Regarding phylogenetic relationships in Paenungulata, we could characterize only one informative locus, although we could isolate many insertions specific to each of three lineages, namely, Proboscidea, Sirenia, and Hyracoidea. These data prompted us to reexamine phylogenetic relationships among Paenungulata using 19 nuclear gene sequences resulting in three different analyses, namely, short interspersed element (SINE) insertions, nuclear sequence analyses, and morphological cladistics, supporting different respective phylogenies. We concluded that these three lineages diverged very rapidly in a very short evolutionary period, with the consequence that ancestral polymorphism present in the last common ancestor of Paenungulata results in such incongruence. Our results suggest the rapid fixation of many large-scale morphological synapomorphies for Tethytheria; implications of this in relation to the morphological evolution in Paenungulata are discussed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/molbev/msi179" target="_blank" rel="noreferrer noopener">10.1093/molbev/msi179</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2005
Afrotheria
base composition
Biochemistry & Molecular Biology
elements
endemic african mammals
Evolution
Evolutionary Biology
Genes
Genetics &
Heredity
Journal Article
mammalian phylogeny
mitochondrial genomes
Molecular Biology and Evolution
molecular evidence
Nikaido M
Nishihara H
Okada N
Paenungulata
placental mammals
retroposons
Satta Y
SINEs
Stanhope M J
Support
Tethytheria
Thewissen J G M