1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.brachy.2012.09.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.brachy.2012.09.003</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
422-427
Issue
5
Volume
12
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Four-year outcomes of hypofractionated high-dose-rate prostate brachytherapy and external beam radiotherapy
Publisher
An entity responsible for making the resource available
Brachytherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-09
Subject
The topic of the resource
cancer; Radiology; Prostate cancer; trial; Nuclear Medicine & Medical Imaging; Oncology; risk; failure; radiation-therapy; adenocarcinoma; boost; Brachytherapy; escalation; hdr brachytherapy; Outcome assessment; stereotactic body radiotherapy
Creator
An entity primarily responsible for making the resource
Chen W C; Tokita K M; Ravera J; Fu P F; Jiang Y; Kaminsky D A; Ponsky L; Ellis R J
Description
An account of the resource
PURPOSE: High-dose-rate (HDR) brachytherapy boost in prostate cancer allows dose escalation and delivery of higher biologically effective dose (BED). We evaluated the outcomes of intensitymodulated radiation therapy (IMRT) and HDR boost in a community setting. METHODS AND MATERIALS: Between July 2003 and April 2008, 148 patients with prostate cancer were treated at Cancer Center of Irvine using two transperineal implants performed 1 week apart (22 Gy delivered in four fractions divided between two insertions and delivered twice daily), followed by IMRT (50.4 Gy). Hormonal therapy was given for 1 year to all patients with Gleason score of 8 or higher. RESULTS: Patient characteristics are as follows: median age at treatment, 71 years; American Joint Committee on Cancer Group 103, 53%; Gleason score of 7, 41%; and Gleason score of 8 or higher, 14%. Median followup was 49 months, and median prostate-specific antigen (PSA) nadir was 0.15 ng/InL. The 4-year actuarial biochemical disease-free survival (bDFS) was 96.8/81% by Phoenix/PSA lower than 0.5 ng/mL criteria. According to National Comprehensive Cancer Center Clinical Practice Guidelines defined recurrence risk groups, 4-year bDFS for low risk was 100/ 92.9%, intermediate risk was 100/86.7%, and high risk was 94/75.4% by Phoenix/PSA lower than 0.5 ng/mL criteria. No statistically significant difference in bDFS was detected by either failure criteria based on risk group, lymph node risk, or initial PSA. Treatment was well tolerated. Subacute/late genitourinary and gastrointestinal toxicities were limited to 10% and 5%, respectively of all patients. CONCLUSIONS: Prostate IMRT plus HDR brachytherapy boost was well tolerated with appropriate PSA response and bDFS at 4 years, demonstrated in a community setting. This treatment schema provides a high BED, comparable with hypofractionated prostate regimens previously reported in the literature. Higher BED delivery should be explored in further dose escalation studies. (C) 2013 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.brachy.2012.09.003" target="_blank" rel="noreferrer noopener">10.1016/j.brachy.2012.09.003</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
Adenocarcinoma
boost
brachytherapy
Cancer
Chen W C
Ellis R J
escalation
failure
Fu P F
hdr brachytherapy
Jiang Y
Journal Article or Conference Abstract Publication
Kaminsky D A
Nuclear Medicine & Medical Imaging
oncology
Outcome Assessment
Ponsky L
Prostate cancer
radiation-therapy
Radiology
Ravera J
Risk
stereotactic body radiotherapy
Tokita K M
trial