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<a href="http://doi.org/10.1111/j.1399-6576.2008.01595.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1399-6576.2008.01595.x</a>
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Pages
931-937
Issue
7
Volume
52
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Title
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Morphine, Opioids, And The Feline Pulmonary Vascular Bed
Publisher
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Acta Anaesthesiologica Scandinavica
Date
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2008
2008-08
Subject
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Anesthesiology; cat; fentanyl; histamine receptor; lung; meperidine; morphine; opioid receptor; remifentanil; sufentanil; vasodepressor
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Kaye A D; Hoover J M; Kaye A J; Ibrahim I N; Fox C; Bajwa A; Anwar M; Fields A M; Baluch A; Huffman S; Chilian W
Description
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Background: Opioid-induced vasodepressor responses have been reported in a variety of species and laboratory models. The aim of this study was to ascertain the relative potencies of different clinically relevant opioids compared with traditional vasodepressor agents in the feline pulmonary vascular bed. A second aim was to study the effects of morphine and to identify the receptors involved in the mediation or the modulation of these effects. Methods: This was a prospective vehicle-controlled study involving an intact chest preparation of adult mongrel cats. The effects of various opioids, morphine, fentanyl, remifentanil, sufentanil, and meperidine were compared with other vasodepressor agents. Additionally, the effects of L-N(5)-(1-iminoethyl) ornithine hydrochloride (L-NIO) (nitric oxide synthase inhibitor), nimesulide [selective cyclooxygenase (COX)-2 inhibitor], glibenclamide (ATP-sensitive K 1 channel blocker), naloxone (non-selective opioid receptor antagonist), and diphenhydramine (histamine H(1)-receptor antagonist) were investigated on pulmonary arterial responses to morphine and other selected agonists in the feline pulmonary vascular bed. The systemic pressure and lobar arterial perfusion pressure were continuously monitored, electronically averaged, and recorded. Results: In the cat pulmonary vascular bed of the isolated left lower lobe, morphine, remifentanil, fentanyl, sufentanil, and meperidine induced a dose-dependent moderate vasodepressor response and it appeared that sufentanil was the most potent on a nanomolar basis. The effects of morphine were not significantly altered after administration of L-NIO, nimesulide, and glibenclamide. However, the vascular responses to morphine were significantly attenuated following administration of naloxone and diphenhydramine. Conclusion: The results of the present study suggest that sufentanil appears to have slightly more potency and morphine the least of the five opioid agonists studied on a nanomolar basis. Morphine-induced vasodilatory responses appeared to be mediated or modulated by both opioid receptor and histamine-receptor-sensitive pathways.
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<a href="http://doi.org/10.1111/j.1399-6576.2008.01595.x" target="_blank" rel="noreferrer noopener">10.1111/j.1399-6576.2008.01595.x</a>
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Journal Article or Conference Abstract Publication
2008
Acta Anaesthesiologica Scandinavica
Anesthesiology
Anwar M
Bajwa A
Baluch A
cat
Chilian W
fentanyl
Fields A M
Fox C
histamine receptor
Hoover J M
Huffman S
Ibrahim I N
Journal Article or Conference Abstract Publication
Kaye A D
Kaye A J
Lung
meperidine
MORPHINE
opioid receptor
remifentanil
sufentanil
vasodepressor