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Text
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URL Address
<a href="http://doi.org/10.1097/00003086-200210000-00033" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00003086-200210000-00033</a>
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Pages
228-231
Issue
403
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Title
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In vitro analysis of antifungal impregnated polymethylmethacrylate bone cement
Publisher
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Clinical Orthopaedics and Related Research
Date
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2002
2002-10
Subject
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arthroplasty; candida-albicans infection; fungal infection; Orthopedics; prosthetic joints; replacement; Surgery
Creator
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Silverberg D; Kodali P; Dipersio J; Acus R; Askew M
Description
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Fungal infection is a rare but devastating complication of total joint arthroplasty. Many patients require removal of the components and resection arthroplasty for cure; however, revision arthroplasty with medicated polymethylmethacrylate bone cement may be used to salvage the joint. Some studies have documented the efficacy of mixing antibiotics with polymethylmethacrylate, but the efficacy of antifungal drugs when mixed with polymethylmethacrylate is unknown. An in vitro agar diffusion method was used in the current study to investigate this potential, and several clinically important conclusions resulted: (1) after incorporation into bone cement, fluconazole and amphotericin B remained active whereas 5-flucytosine did not, (2) inhibitory activity improved with greater drug concentrations, and (3) more drug eluted from Palacos(R) R than Simplex(R) P cement.
Identifier
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<a href="http://doi.org/10.1097/00003086-200210000-00033" target="_blank" rel="noreferrer noopener">10.1097/00003086-200210000-00033</a>
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Journal Article
2002
Acus R
Arthroplasty
Askew M
candida-albicans infection
Clinical orthopaedics and related research
Dipersio J
fungal infection
Journal Article
Kodali P
Orthopedics
prosthetic joints
Replacement
Silverberg D
Surgery