1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/ENEURO.0309-16.2016" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/ENEURO.0309-16.2016</a>
Issue
6
Volume
3
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Synaptic Inhibition in Avian Interaural Level Difference Sound Localizing Neurons.
Publisher
An entity responsible for making the resource available
eNeuro
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-12
Subject
The topic of the resource
Female; Male; Animals; Acoustic Stimulation/methods; Tissue Culture Techniques; Chick Embryo; Patch-Clamp Techniques; *dorsal nucleus of the lateral lemniscus; *GABAA receptor; *interaural level difference; *reversal potential; *synaptic inhibition; Anions/metabolism; Avian Proteins/metabolism; Brain Stem/cytology/drug effects/*physiology; Chlorides/metabolism; Electric Stimulation; gamma-Aminobutyric Acid/metabolism; Intracellular Space/drug effects/metabolism; Neural Inhibition/drug effects/*physiology; Neurons/cytology/drug effects/*physiology; Sound Localization/drug effects/*physiology; Symporters/metabolism; Synaptic Transmission/drug effects/*physiology; Receptors; GABA-A/metabolism; Glycine/metabolism
Creator
An entity primarily responsible for making the resource
Curry Rebecca J; Lu Yong
Description
An account of the resource
Synaptic inhibition plays a fundamental role in the neural computation of the interaural level difference (ILD), an important cue for the localization of high-frequency sound. Here, we studied the inhibitory synaptic currents in the chicken posterior portion of the dorsal nucleus of the lateral lemniscus (LLDp), the first binaural level difference encoder of the avian auditory pathway. Using whole-cell recordings in brain slices, we provide the first evidence confirming a monosynaptic inhibition driven by direct electrical and chemical stimulation of the contralateral LLDp, establishing the reciprocal inhibitory connection between the two LLDps, a long-standing assumption in the field. This inhibition was largely mediated by GABAA receptors; however, functional glycine receptors were also identified. The reversal potential for the Cl(-) channels measured with gramicidin-perforated patch recordings was hyperpolarizing (-88 mV), corresponding to a low intracellular Cl(-) concentration (5.2 mm). Pharmacological manipulations of KCC2 (outwardly Cl(-) transporter) activity demonstrate that LLDp neurons can maintain a low intracellular Cl(-) concentration under a high Cl(-) load, allowing for the maintenance of hyperpolarizing inhibition. We further demonstrate that hyperpolarizing inhibition was more effective at regulating cellular excitability than depolarizing inhibition in LLDp neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1523/ENEURO.0309-16.2016" target="_blank" rel="noreferrer noopener">10.1523/ENEURO.0309-16.2016</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*dorsal nucleus of the lateral lemniscus
*GABAA receptor
*interaural level difference
*reversal potential
*synaptic inhibition
2016
Acoustic Stimulation/methods
Animals
Anions/metabolism
Avian Proteins/metabolism
Brain Stem/cytology/drug effects/*physiology
Chick Embryo
Chlorides/metabolism
Curry Rebecca J
Department of Anatomy & Neurobiology
Electric Stimulation
eNeuro
Female
GABA-A/metabolism
gamma-Aminobutyric Acid/metabolism
Glycine/metabolism
Intracellular Space/drug effects/metabolism
Lu Yong
Male
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurons/cytology/drug effects/*physiology
Patch-Clamp Techniques
Receptors
Sound Localization/drug effects/*physiology
Symporters/metabolism
Synaptic Transmission/drug effects/*physiology
Tissue Culture Techniques
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2013.10.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2013.10.003</a>
Pages
131–144
Volume
306
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Auditory cortical axons contact commissural cells throughout the guinea pig inferior colliculus.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-12
Subject
The topic of the resource
AC; Animals; auditory cortex; Auditory Cortex/*physiology; Auditory Pathways/cytology; Axons/metabolism/*pathology; Brain Mapping; cortical layers; Fast Blue; FB; FD; Female; FG; Fluor0Ruby; fluorescein dextran; Fluorescence; FluoroGold; FR; G-; G+; GAD; GAD-immunonegative; GAD-immunopositive; GAD-neg; gamma-Aminobutyric Acid/metabolism; GB; Glutamate Decarboxylase/metabolism; glutamic acid decarboxylase; green RetroBeads; Guinea Pigs; I-VI; IC; IC central nucleus; IC dorsal cortex; IC lateral cortex; IC rostral cortex; ICc; ICd; IClc; ICrc; Inferior Colliculi/pathology/*physiology; inferior colliculus; Male; Mesencephalon/pathology; Microscopy; ps; pseudosylvian sulcus; rhinal sulcus; rs; white matter; wm
Creator
An entity primarily responsible for making the resource
Nakamoto Kyle T; Sowick Colleen S; Schofield Brett R
Description
An account of the resource
Projections from auditory cortex (AC) affect how cells in both inferior colliculi (IC) respond to acoustic stimuli. The large projection from the AC to the ipsilateral IC is usually credited with the effects in the ipsilateral IC. The circuitry underlying effects in the contralateral IC is less clear. The direct projection from the AC to the contralateral IC is relatively small. An unexplored possibility is that the large ipsilateral cortical projection contacts the substantial number of cells in the ipsilateral IC that project through the commissure to the contralateral IC. Apparent contacts between cortical boutons and commissural cells were identified in the left IC after injection of different fluorescent tracers into the left AC and the right IC. Commissural cells were labeled throughout the left IC, and many (23-34%) appeared to be contacted by cortical axons. In the central nucleus, both disc-shaped and stellate cells were contacted. Antibodies to glutamic acid decarboxylase (GAD) were used to identify GABAergic commissural cells. The majority (\textgreater86%) of labeled commissural cells were GAD-immunonegative. Despite low numbers of GAD-immunopositive commissural cells, some of these cells were contacted by cortical boutons. Nonetheless, most cortically contacted commissural cells were GAD-immunonegative (i.e., presumably glutamatergic). We conclude that auditory cortical axons contact primarily excitatory commissural cells in the ipsilateral IC that project to the contralateral IC. These corticocollicular contacts occur in each subdivision of the ipsilateral IC, suggesting involvement of commissural cells throughout the IC. This pathway - from AC to commissural cells in the ipsilateral IC - is a prime candidate for the excitatory effects of activation of the auditory cortex on responses in the contralateral IC. Overall this suggests that the auditory corticofugal pathway is integrated with midbrain commissural connections.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2013.10.003" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2013.10.003</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
AC
Animals
auditory cortex
Auditory Cortex/*physiology
Auditory Pathways/cytology
Axons/metabolism/*pathology
Brain Mapping
cortical layers
Department of Anatomy & Neurobiology
Fast Blue
FB
FD
Female
FG
Fluor0Ruby
fluorescein dextran
Fluorescence
FluoroGold
FR
G-
G+
GAD
GAD-immunonegative
GAD-immunopositive
GAD-neg
gamma-Aminobutyric Acid/metabolism
GB
Glutamate Decarboxylase/metabolism
glutamic acid decarboxylase
green RetroBeads
Guinea Pigs
Hearing research
I-VI
IC
IC central nucleus
IC dorsal cortex
IC lateral cortex
IC rostral cortex
ICc
ICd
IClc
ICrc
Inferior Colliculi/pathology/*physiology
inferior colliculus
Male
Mesencephalon/pathology
Microscopy
Nakamoto Kyle T
NEOMED College of Medicine
ps
pseudosylvian sulcus
rhinal sulcus
rs
Schofield Brett R
Sowick Colleen S
white matter
wm
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00040.2009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00040.2009</a>
Pages
1004–1016
Issue
2
Volume
102
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Glycinergic inhibition creates a form of auditory spectral integration in nuclei of the lateral lemniscus.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-08
Subject
The topic of the resource
Acoustic Stimulation; Action Potentials/drug effects; Animals; Auditory Perception/drug effects/*physiology; Bicuculline/pharmacology; Brain Stem/drug effects/*physiology; Chiroptera; GABA Antagonists/pharmacology; GABA-A Receptor Antagonists; GABA-A/metabolism; gamma-Aminobutyric Acid/metabolism; Glycine Agents/pharmacology; Glycine/*physiology; Glycine/antagonists & inhibitors/metabolism; Microelectrodes; Neural Inhibition/drug effects/*physiology; Neurons/drug effects/*physiology; Receptors; Strychnine/pharmacology
Creator
An entity primarily responsible for making the resource
Peterson Diana Coomes; Nataraj Kiran; Wenstrup Jeffrey
Description
An account of the resource
For analyses of complex sounds, many neurons integrate information across different spectral elements via suppressive effects that are distant from the neurons' excitatory tuning. In the mustached bat, suppression evoked by sounds within the first sonar harmonic (23-30 kHz) or in the subsonar band (\textless23 kHz) alters responsiveness to the higher best frequencies of many neurons. This study examined features and mechanisms associated with low-frequency (LF) suppression among neurons of the lateral lemniscal nuclei (NLL). We obtained extracellular recordings from neurons in the intermediate and ventral nuclei of the lateral lemniscus, observing different forms of LF suppression related to the two above-cited frequency bands. To understand the mechanisms underlying this suppression in NLL neurons, we examined the roles of glycinergic and GABAergic input through local microiontophoretic application of strychnine, an antagonist to glycine receptors (GlyRs), or bicuculline, an antagonist to gamma-aminobutyric acid type A receptors (GABA(A)Rs). With blockade of GABA(A)Rs, neurons showed an increase in firing rate to best frequency (BF) and/or LF tones but retained LF suppression of BF sounds. For neurons that displayed LF suppression tuned to
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00040.2009" target="_blank" rel="noreferrer noopener">10.1152/jn.00040.2009</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Acoustic Stimulation
Action Potentials/drug effects
Animals
Auditory Perception/drug effects/*physiology
Bicuculline/pharmacology
Brain Stem/drug effects/*physiology
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
GABA Antagonists/pharmacology
GABA-A Receptor Antagonists
GABA-A/metabolism
gamma-Aminobutyric Acid/metabolism
Glycine Agents/pharmacology
Glycine/*physiology
Glycine/antagonists & inhibitors/metabolism
Journal of neurophysiology
Microelectrodes
Nataraj Kiran
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurons/drug effects/*physiology
Peterson Diana Coomes
Receptors
Strychnine/pharmacology
Wenstrup Jeffrey
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1113/jphysiol.2012.230136" target="_blank" rel="noreferrer noopener">http://doi.org/10.1113/jphysiol.2012.230136</a>
Pages
3787–3805
Issue
16
Volume
590
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Two GABAA responses with distinct kinetics in a sound localization circuit.
Publisher
An entity responsible for making the resource available
The Journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-08
Subject
The topic of the resource
*Sound; Animals; Chick Embryo; Chickens; Female; GABA-A/*physiology; gamma-Aminobutyric Acid/metabolism; Male; Neurons/*metabolism; Pitch Discrimination; Receptors; Sound Localization/*physiology; Synapses/physiology
Creator
An entity primarily responsible for making the resource
Tang Zheng-Quan; Lu Yong
Description
An account of the resource
The temporal characteristics and functional diversity of GABAergic inhibition are determined by the spatiotemporal neurotransmitter profile, intrinsic properties of GABAA receptors, and other factors. Here, we report two distinct GABAA responses and the underlying mechanisms in neurons of the chicken nucleus laminaris (NL), the first encoder of interaural time difference for sound localization in birds. The time course of the postsynaptic GABAA currents in NL neurons, recorded with whole-cell voltage clamp, differed between different characteristic frequency (CF) regions. Compared to low-CF (LF) neurons, middle/high-CF (MF/HF) neurons had significantly slower IPSCs, with a 2.6-fold difference in the decay time constants of spontaneous IPSCs and a 5.3-fold difference in the decay of IPSCs elicited by single-pulse stimulus. Such differences were especially dramatic when IPSCs were elicited by train stimulations at physiologically relevant frequencies, and at high stimulus intensities. To account for these distinct GABAA responses, we showed that MF/HF neurons exhibited more prominent asynchronous release of GABA. Supporting this observation, replacement of extracellular Ca2+ with Sr2+ increased the decay of IPSCs in LF neurons, and EGTA-AM reduced the decay of IPSCs in MF/HF neurons. Furthermore, pharmacological evidence suggests that GABA spillover plays a greater role in prolonging the IPSCs of MF/HF neurons. Consequently, under whole-cell current clamp, synaptically released GABA produced short- and long-lasting suppression of the neuronal excitability of LF and MF/HF neurons, respectively. Taken together, these results suggest that the GABAergic inputs to NL neurons may exert a dynamic modulation of interaural time difference (ITD) coding in a CF-dependent manner.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1113/jphysiol.2012.230136" target="_blank" rel="noreferrer noopener">10.1113/jphysiol.2012.230136</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sound
2012
Animals
Chick Embryo
Chickens
Department of Anatomy & Neurobiology
Female
GABA-A/*physiology
gamma-Aminobutyric Acid/metabolism
Lu Yong
Male
NEOMED College of Medicine
Neurons/*metabolism
Pitch Discrimination
Receptors
Sound Localization/*physiology
Synapses/physiology
Tang Zheng-Quan
The Journal of physiology