1
40
5
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1285-1286
Issue
8
Volume
74
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The heart of women's health
Publisher
An entity responsible for making the resource available
American Family Physician
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-10
Subject
The topic of the resource
cardiovascular health; disease; gender-differences; General & Internal Medicine; risk; symptoms
Creator
An entity primarily responsible for making the resource
Plate D S; Hughes S
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2006
American family physician
cardiovascular health
Disease
gender-differences
General & Internal Medicine
Hughes S
Journal Article
Plate D S
Risk
Symptoms
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.yfrne.2012.02.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.yfrne.2012.02.003</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
169-178
Issue
2
Volume
33
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Signaling pathways mediating the neuroprotective effects of sex steroids and SERMs in Parkinson's disease
Publisher
An entity responsible for making the resource available
Frontiers in Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-04
Subject
The topic of the resource
Signaling; Neuroprotection; MPTP; mice; Akt; 3; 2; 1-methyl-4-phenyl-1; 6-tetrahydropyridine; receptor; Neurosciences & Neurology; Endocrinology & Metabolism; nervous-system; plasma-membrane; estrogen-receptor-alpha; er-alpha; gender-differences; rat-brain; striatum; estrogen; ERK; estradiol; growth-factor-i; protein-coupled receptor-30; selective estrogen; SERMs; Substantia nigra
Creator
An entity primarily responsible for making the resource
Bourque M; Dluzen D E; Di Paolo T
Description
An account of the resource
Studies with the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model of Parkinson's disease have shown the ability of 17 beta-estradiol to protect the nigrostriatal dopaminergic system. This paper reviews the signaling pathways mediating the neuroprotective effect of 17 beta-estradiol against MPTP-induced toxicity. The mechanisms of 17 beta-estradiol action implicate activation of signaling pathways such as the phosphatidylinositol-3 kinase/Akt and the mitogen-activated protein kinase pathways. 17 beta-estradiol signaling is complex and integrates multiple interactions with signaling molecules that act to potentiate a protective effect. 17 beta-estradiol signaling is mediated via estrogen receptors, including GPER1, but others receptors, such as the IGF-1 receptor, are implicated in the neuroprotective effect. Glial and neuronal crosstalk is a critical factor in the maintenance of dopamine neuronal survival and in the neuroprotective action of 17 beta-estradiol. Compounds that stimulate GPER1 such as selective estrogen receptor modulators and phytoestrogens show neuroprotective activity and are alternatives to 17 beta-estradiol. (C) 2012 Published by Elsevier Inc.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.yfrne.2012.02.003" target="_blank" rel="noreferrer noopener">10.1016/j.yfrne.2012.02.003</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1-Methyl-4-phenyl-1
2
2012
3
6-tetrahydropyridine
Akt
Bourque M
Di Paolo T
Dluzen D E
Endocrinology & Metabolism
er-alpha
ERK
estradiol
estrogen
estrogen-receptor-alpha
Frontiers in Neuroendocrinology
gender-differences
growth-factor-i
Journal Article or Conference Abstract Publication
Mice
MPTP
nervous-system
Neuroprotection
Neurosciences & Neurology
plasma-membrane
protein-coupled receptor-30
rat-brain
Receptor
selective estrogen
SERMs
Signaling
striatum
SUBSTANTIA nigra
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bcp.2007.07.009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bcp.2007.07.009</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1413-1423
Issue
9
Volume
74
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Tamoxifen protects male mice nigrostriatal dopamine against methamphetamine-induced toxicity
Publisher
An entity responsible for making the resource available
Biochemical Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-11
Subject
The topic of the resource
disease; Pharmacology & Pharmacy; microglial activation; parkinsons-disease; Substantia nigra; messenger-rna; dopamine; transporter; neurotoxicity; Neuroprotection; estrogen-receptor-alpha; induced; striatum; gender-differences; estradiol; Parkinson's; striatal tissue fragments; Substantia nigra
Creator
An entity primarily responsible for making the resource
Bourque M; Liu B; Dluzen D E; Di Paolo T
Description
An account of the resource
The selective estrogen receptor modulator tamoxifen and estradiol were shown to protect nigrostriatal dopamine concentration loss by methamphetamine in female mice whereas male mice were protected only by tamoxifen. The present study examined the protective properties of tarnoxifen in male mice on several nigrostriatal dopaminergic markers and body temperature. Intact male mice were administered 12.5 or 50 mu g tarnoxifen 24 h before methamphetamine treatment. Basal body temperatures of male mice remained unchanged by the tarnoxifen treatment. Methamphetamine reduced striatal dopamine and its metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid concentrations, striatal and substantia nigra dopamine and vesicular monoamine transporter specific binding as well substantia nigra dopamine and vesicular monoamine transporter mRNA levels and increased striatal preproenkephalin mRNA levels. These methamphetamine effects were not altered by 12.5 mu g tarnoxifen except for increased striatal dopamine metabolites and turnover. Tamoxifen at 50 mu g reduced the methamphetamine effect on striatal dopamine concentration, dopamine transporter specific binding and prevented the increase in preproenkephalin mRNA levels; in the substantia nigra tamoxifen prevented the decrease of dopamine transporter mRNA levels. The present results show a tamoxifen dose-dependent prevention of loss of various dopaminergic markers against methamphetamine-induced toxicity in male mice. Since this is the only known hormonal protection of male mice against methamphetamine toxicity, these findings provide important new information on specific parameters of nigrostriatal dopaminergic function preserved by tarnoxifen. (C) 2007 Published by Elsevier Inc.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bcp.2007.07.009" target="_blank" rel="noreferrer noopener">10.1016/j.bcp.2007.07.009</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2007
Biochemical pharmacology
Bourque M
Di Paolo T
Disease
Dluzen D E
Dopamine
estradiol
estrogen-receptor-alpha
gender-differences
Induced
Journal Article or Conference Abstract Publication
Liu B
messenger-rna
microglial activation
Neuroprotection
Neurotoxicity
Parkinson's
parkinsons-disease
Pharmacology & Pharmacy
striatal tissue fragments
striatum
SUBSTANTIA nigra
transporter
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000079664" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000079664</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
296-304
Issue
6
Volume
79
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dopamine Transporter As A Marker Of Neuroprotection In Methamphetamine-lesioned Mice Treated Acutely With Estradiol
Publisher
An entity responsible for making the resource available
Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
1905-06
Subject
The topic of the resource
17-beta-estradiol; brain; depletion; dopamine transporter; Endocrinology & Metabolism; estrogen; gender-differences; gonadal steroids; induced neurotoxicity; methamphetamine; neuroprotection; Neurosciences & Neurology; parkinsons-disease; progesterone; rat; striatal dopamine; striatum; substantia nigra; system
Creator
An entity primarily responsible for making the resource
D'Astous M; Gajjar T M; Dluzen D E; Di Paolo T
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000079664" target="_blank" rel="noreferrer noopener">10.1159/000079664</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
17-beta-estradiol
2004
Brain
D'Astous M
depletion
Di Paolo T
Dluzen D E
Dopamine transporter
Endocrinology & Metabolism
estrogen
Gajjar T M
gender-differences
gonadal steroids
induced neurotoxicity
Methamphetamine
Neuroendocrinology
Neuroprotection
Neurosciences & Neurology
parkinsons-disease
progesterone
rat
striatal dopamine
striatum
SUBSTANTIA nigra
system
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
140-150
Volume
1139
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex Differences In Dopamine- And Vesicular Monoamine-transporter Functions Implications For Methamphetamine Use And Neurotoxicity
Publisher
An entity responsible for making the resource available
Drug Addiction: Research Frontiers and Treatment Advances
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008
Subject
The topic of the resource
abuse; addiction; cd-1 mice; dopaminergic; drug abuse; estrogen; estrous-cycle; evoked striatal dopamine; female; gender-differences; gender-differences; inhibition; nigrostriatal; output; rats; sites; toxicity; uptake
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Book Chapter
2008
abuse
Addiction
cd-1 mice
Dluzen D E
dopaminergic
Drug abuse
Drug Addiction: Research Frontiers and Treatment Advances
estrogen
estrous-cycle
evoked striatal dopamine
Female
gender-differences
inhibition
McDermott J L
nigrostriatal
output
Rats
sites
toxicity
uptake